Journals / Van Tıp Dergisi / 2017 / Cilt: 24 - Sayı: 4

Development of Acute Sacroiliitis Due to the Use of Oral Isotretinoin in Patients with Acne Vulgaris: Four Case Presentations

Akne Vulgarisli Hastalarda Oral İzotretinoin Kullanımına Bağlı Gelişen Akut Sakroiliit: Dört Olgu Sunumu

Pages
372–377
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this study, we present 4 cases of acne vulgaris with acute sacroiliitis caused by oral isotretionin.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Sacroiliitis, an inflammation of the sacroiliac joint, is a characteristic finding of ankylosing spondylitis.
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Key Findings & Data:The cessation of drug after early diagnosis, nonsteroidal antiinflammatory treatment, physical rehabilitation and exercise programs limit the progression of disease and the patients can reach their normal functions within 6 months.
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Conclusion & Impact:In this study, we present 4 cases of acne vulgaris with acute sacroiliitis caused by oral isotretionin.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Sacroiliitis, an inflammation of the sacroiliac joint, is a characteristic finding of ankylosing spondylitis. Acute sacroiliitis has been described relatively uncommonly, and typically featuring the underlying infectious, rheumatic, neoplastic, or drug-related causality. Acne vulgaris is a chronic inflammatory disease affecting the pilosebaceous unit. Oral isotretinoin is a synthetic vitamin A derivative that has been used to treat severe nodulocystic acne and resistant acne to systemic antibiotic therapy. Few cases have been reported about acute sacroiliitis occurrence due to oral isotretionin treatment in patients with acne vulgaris. The mechanism of sacroiliitis owing to the use of oral isotretionin is not clear. The cessation of drug after early diagnosis, nonsteroidal antiinflammatory treatment, physical rehabilitation and exercise programs limit the progression of disease and the patients can reach their normal functions within 6 months. In this study, we present 4 cases of acne vulgaris with acute sacroiliitis caused by oral isotretionin.

Özet

Sakroiliit, sakroiliak eklemin inflamasyonu olup en sık ankilozan spondilit hastalarında görülür. Akut sakroiliit ise altta yatan enfeksiyöz, romatolojik, neoplastik veya ilaç-ilişkili nedenlere bağlı olarak daha nadir izlenir. Akne vulgaris, pilosebase üniteyi etkileyen kronik inflamatuar bir hastalıktır. Oral izotretinoin şiddetli nodülokistik ve sistemik antibiyotik tedavilerine dirençli aknede verilen sentetik A vitamini türevidir. Akne vulgarisi olan hastalarda oral izotretinoin kullanımına bağlı az sayıda akut sakroiliit olgusu rapor edilmiştir. Izotretinoin kullanımına bağlı sakroiliit gelişiminin mekanizması tam olarak bilinmemektedir. Erken tanı sonrasında ilacın kesilmesi, nonsteroid antiinflamatuar tedavi, fizik tedavi ve egzersiz programı ile hastalık sınırlanmakta ve 6 ay içinde hastalar normal fonksiyonlarına kavuşmaktadır. Biz bu çalışmamızda, oral izotretinoin kullanımına bağlı gelişen akne vulgarisli 4 akut sakroiliit olgusu sunduk.

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Cite This Article

KÖSE, Ö. K., HIZ, Ö., GÖKALP, H., ÜSTÜNER, P. D. (2017). Development of Acute Sacroiliitis Due to the Use of Oral Isotretinoin in Patients with Acne Vulgaris: Four Case Presentations. Van Tıp Dergisi, Cilt: 24 - Sayı: 4, 372–377. https://ajindex.com/articles/334009

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