SavedAdd your journal

Journals / International Journal of Medical Biochemistry / 2021 / Cilt: 4 - Sayı: 3

Distribution of thalassemia trait in Balikesir Province according to trait type and age group

Uğur ERÇİN
Pages
166–171
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: The prevalence of β-thalassemia trait (5.11%) in the study group was extrapolated for the general pop ulation of Balikesir (2019 population: 1,228.620 ) and it was estimated that there were 62,782 potential carriers in the province.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: The aim of this study was to determine the prevalence of the thalassemia disease group in Balikesir Prov ince, Turkey.
📊
Key Findings & Data:Methods: Blood samples provided by 11,558 individuals (5675 males and 5883 females) aged 3-90 years between May 15, 2018 and September 30, 2019 for laboratory analysis at the Balikesir Provincial Public Health Laboratory were included in the study.
💡
Conclusion & Impact:Conclusion: The prevalence of β-thalassemia trait (5.11%) in the study group was extrapolated for the general pop ulation of Balikesir (2019 population: 1,228.620 ) and it was estimated that there were 62,782 potential carriers in the province.
🔬Design:Research Article
📍Scope:2018 Verileri
⚙️Variables:Domain Parameters

Özet

Objectives: The aim of this study was to determine the prevalence of the thalassemia disease group in Balikesir Prov ince, Turkey. Methods: Blood samples provided by 11,558 individuals (5675 males and 5883 females) aged 3-90 years between May 15, 2018 and September 30, 2019 for laboratory analysis at the Balikesir Provincial Public Health Laboratory were included in the study. Hemoglobin chain analyses were carried out using the high-performance liquid chromatography (HPLC) method. The data obtained were analyzed retrospectively. Results: The level of hemoglobin (Hb) A2 was >3.5% in 591 (5.11%) of the total study group and these individuals were identified as β-thalassemia carriers. The prevalence of the β-thalassemia trait was 5.76% in females and 4.44% in males. A total of 792 cases (446 female and 346 male) had a result outside the normal range: 74.6% were identified as thalassemia carriers, 9.4% had isolated low Hb A2, 12.3% had isolated Hb F elevation, and 3.8% had total abnormal hemoglobin values. Conclusion: The prevalence of β-thalassemia trait (5.11%) in the study group was extrapolated for the general pop ulation of Balikesir (2019 population: 1,228.620 ) and it was estimated that there were 62,782 potential carriers in the province.

🔖

Cite This Article

ERÇİN, U. (2021). Distribution of thalassemia trait in Balikesir Province according to trait type and age group. International Journal of Medical Biochemistry, Cilt: 4 - Sayı: 3, 166–171. https://ajindex.com/articles/413644

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (17)

  1. Musallam KM, Rivella S, Vichinsky E, Rachmilewitz EA. Non-transfusion-dependent thalassemias. Haematologica 2013;98(6):833-44
  2. De Sanctis V, Kattamis C, Canatan D, Soliman AT, Elsedfy H, Karimi M, et al. β-Thalassemia distribution in the old world: an ancient disease seen from a historical standpoint. Mediterr J Hematol Infect Dis 2017;9(1):e2017018
  3. Khandros E, Kwiatkowski JL. Beta Thalassemia: monitoring and new treatment approaches. Hematol Oncol Clin North Am 2019;33(3):339-53
  4. Mettananda S, Higgs DR. Molecular basis and genetic modifiers of thalassemia. Hematol Oncol Clin North Am 2018;32(2):177-91
  5. Taher AT, Weatherall DJ, Cappellini MD. Thalassaemia. Lancet 2018;391(10116):155-67
  6. Khan MI, Khan HN, Usman M. β-thalassemia trait; diagnostic importance of haematological indices in detecting β-thalassemia trait patients. Professional Med J 2018;25:545-50
  7. Yalcintepe S. β-globin mutations in β-thalassemia minor patients in Genetics Diagnosis Center of Trakya University Faculty of Medicine. Ege Journal of Medicine 2019;58(4):330-5
  8. Taher AT, Cappellini MD, Musallam KM. Recent advances and treatment challenges in patients with non-transfusion-dependent thalassemia. Blood Rev 2012;26 Suppl 1:S1-2
  9. Kazgan T, Yagci-Kupeli B. Respiratory system disorders in thalasemia. Archives Medical Review Journal 2017;26(3):352-77
  10. Altikat S, Kuru HI, Gunay R, Turkmen K, Seyit M. Prevalence of β-thalassemia trait in Kutahya: A city in the eastern part of Aegean region in Turkey. SAS J Med 2016;2(1):1-4
  11. Söylemez-Gökyer D, Kayaaltı Z. Türkiye’de orak hücreli anemi dağılımı, patofizyolojisi ve demir toksisitesi. Marmara Pharm J 2016;20(2):92-9
  12. Brancaleoni V, Di Pierro E, Motta I, Cappellini MD. Laboratory diagnosis of thalassemia. Int J Lab Hematol 2016;38 Suppl 1:32-40
  13. Mikhael NL, Zeid MY. Detection of prevalence of β-thalassemia trait in children attending a tertiary pediatric university hospital for non-hematological disorders using red blood cell indices. Indian J Child Health 2019;6:405-8
  14. Altay C. Abnormal hemoglobins in Turkey. Turk J Haematol 2002;19(1):63-74
  15. Zhu Y, Shen N, Wang X, Xiao J, Lu Y. Alpha and beta-Thalassemia mutations in Hubei area of China. BMC Med Genet 2020;21:6
  16. Yao XY, Yu J, Chen SP, Xiao JW, Zheng QC, Liu HY, et al. Prevalence and genetic analysis of α-thalassemia and β-thalassemia in Chongqing area of China. Gene 2013;532(1):127-31
  17. Fucharoen S, Winichagoon P. Haemoglobinopathies in so