Pulmoner Hipertansiyonda Genetik ve Biyobelirteçler: Günlük Uygulamaya Ne Kadar Girdi?

References (11)

1. Hansmann G. Koestenberger M. et al. 2019 updated consensus statement on the diagnosis and treatment of pediatric pulmonary hypertension: The European Pediatric Pulmonary Vascular Disease Network (EPPVDN), endorsed by AEPC, ESPR and ISHLT. J Heart Lung Transplant. 2019; 38(9):879­901
2. Sztrymf B. Coulet F. Girerd B. et al. Clinical outcomes of pulmonary arterial hypertension in carriers of BMPR2 mutation. Am J Respir Crit Care Med. 2008;177(12):1377­83. doi: 10.1164/rccm.200712­1807OC
3. Girerd B. Montani D. Coulet F. et al. Clinical outcomes of pulmonary arterial hypertension in patients carrying an ACVRL1 (ALK1) mutation. Am J Respir Crit Care Med. 2010;181(8):851­61. doi: 10.1164/rccm.200908­1284OC
4. Montani D. Girerd B. Jaïs X. et al. Clinical phenotypes and outcomes of heritable and sporadic pulmonary veno­occlusive disease: a population­based study. Lancet Respir Med. 2017;5(2):125­34
5. Hemnes AR. Trammell AW. Archer SL. et al. Peripheral blood signature of vasodilator­responsive pulmonary arterial hypertension. Circulation. 2015;131(4):401­9
6. Rhodes CJ. Wharton J. Ghataorhe P. et al. Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study. Lancet Respir Med. 2017; 5(9):717­26. doi:10.1016/S2213­2600(17)301 61­3
7. Rhodes CJ. Ghataorhe P. Wharton J. et al. Plasma Meta bo ­ lomics Implicates Modified Transfer RNAs and Altered Bioenergetics in the Outcomes of Pulmonary Arterial Hypertension. Circulation. 2017;135(5):460­75. doi: 10.11 61/Circulationaha.116.024602
8. Kocken JMM. and da Costa Martins PA. Epigenetics. Int J Mol Sci. 2020;21(23):8901. doi.org/10.3390/ijms21238901. 9. de la Cuesta F. Passalacqua I. Rodor J. Bhushan R. Denby L. Baker AH. Extracellular vesicle cross­talk between pulmonary artery smooth muscle cells and endothelium during excessive TGF­β signalling: implications for PAH vascular remodelling. Cell Commun Signal. 2019;17(1):143. doi: 10.1186/s12964­019­0449­9
9. Broza YY. Zuri L. Haick H. Combined volatolomics for monitoring of human body chemistry. Sci Rep. 2014;4:4611. doi: 10.1038/srep04611
10. Giannoukos S. Brkić B. Taylor S. Marshall A. Verbeck GF. Chemical Sniffing Instrumentation for Security Appli ca ti ­ ons. Chem Rev. 2016;116(14):8146­72. doi: 10.1021/acs. chemrev.6b00065
11. Nakhleh MK. Humbert M. Fadel E. Haick H. CohenKaminsky S. Breath volatolome for the detection of pulmonary arterial hypertension. Am J Crit Care Med. 2016; 193: A7354. 13. https:/