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Journals / Turkish Journal of Hematology / 2000 / Cilt: 17 - Sayı: 3

Could parvovirus B19 induce a rejection after bone marrow transplantation in a patient with Diamond-Blackfan anemia?

Nevin YALMAN
Sema ANAK
Nazan SARPER
Hülya BİLGEN
Semra ÖZGENÇ
Emine CAN
Gündüz GEDİKOĞLU
Pages
137–141
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Although mixed chimerism detected shortly after the BMT procedure might raise the possibility of an ongoing slow graft rejection during the relatively stable remission period, we think that parvovirus B19 had also contributed rejection.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:A four year-old-girl with Diamond-Blackfan anemia (DBA) that was resistant to corticosteroid treatment and transfusion dependent underwent (bone marrow transplantation) BMT from HLA identical sibling.
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Key Findings & Data:For the following 13 months she was not transfusion dependent and had a 100% Karnofsky score.
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Conclusion & Impact:Although mixed chimerism detected shortly after the BMT procedure might raise the possibility of an ongoing slow graft rejection during the relatively stable remission period, we think that parvovirus B19 had also contributed rejection.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Greftin reddedilmesi · Çocuk · Kemik iliği nakli

Özet

A four year-old-girl with Diamond-Blackfan anemia (DBA) that was resistant to corticosteroid treatment and transfusion dependent underwent (bone marrow transplantation) BMT from HLA identical sibling. The patient was conditioned with busulfan and cyclophosphamide and achieved complete marrow engraftment and mixed chimerism in DNA analysis. For the following 13 months she was not transfusion dependent and had a 100% Karnofsky score. But on the 14th month she had anemia following fever, rash and enteritis. Parvovirus B19 IgM seropositivity confirmed Parvovirus infection. Although intravenous immunoglobulin was administered, bone marrow morphology and DNA analysis revealed rejection. Although mixed chimerism detected shortly after the BMT procedure might raise the possibility of an ongoing slow graft rejection during the relatively stable remission period, we think that parvovirus B19 had also contributed rejection.

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Cite This Article

YALMAN, N., ANAK, S., SARPER, N., BİLGEN, H., ÖZGENÇ, S., CAN, E., GEDİKOĞLU, G. (2000). Could parvovirus B19 induce a rejection after bone marrow transplantation in a patient with Diamond-Blackfan anemia?. Turkish Journal of Hematology, Cilt: 17 - Sayı: 3, 137–141. https://ajindex.com/articles/413449

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