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Journals / Turkish Journal of Hematology / 2000 / Cilt: 17 - Sayı: 4

Prognostic significance of Wilms tumor 1 gene in childhood acute lymphoblastic leukemia

ÜNSAL ÖZGEN
Sema ANAK
Uğur ÖZBEK
Nazan SARPER
Ertuğrul ERYILMAZ
Leyla AĞAOĞLU
Ömer DEVECİOĞLU
Nevin YALMAN
Gündüz GEDİKOĞLU
Pages
183–188
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Event free survival (EFS) and overall survival (OS) of WT1 positive and negative patients were also not significant.

📌 3 Key Takeaways

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Objective & Hypothesis:Wilms tumor 1 (WT1) gene is a tumor supressor gene, expressed in malignant and normal hematopoietic progenitor cells.
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Key Findings & Data:We evaluated the presence of WT1 expression in bone marrow samples of 28 children with de novo ALL at diagnosis by two step RT-PCR.
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Conclusion & Impact:Event free survival (EFS) and overall survival (OS) of WT1 positive and negative patients were also not significant.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Kök hücreler · Gen ekspresyonu · Lösemi

Özet

Wilms tumor 1 (WT1) gene is a tumor supressor gene, expressed in malignant and normal hematopoietic progenitor cells. Prognostic significance of this gene in childhood acute lymphoid leukemia (ALL) is not clear. We evaluated the presence of WT1 expression in bone marrow samples of 28 children with de novo ALL at diagnosis by two step RT-PCR. Expression of WT1 gene was detected in 78.5% of patients. There was no correlation between WT1 gene expression and age, sex, FAB type, leukocyte count, and presence of t(4;11) and t(9;22). All patients were treated with modified BFM 86 protocol. There was no difference in the complete remission (CR) rate between WT1 positive and negative patients. Event free survival (EFS) and overall survival (OS) of WT1 positive and negative patients were also not significant. We conclude that expression of WT1 gene is not associated with specific characteristics of ALL blast cells and is not a prognostic factor for CR, remission duration and overall survival.

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Cite This Article

ÖZGEN, Ü., ANAK, S., ÖZBEK, U., SARPER, N., ERYILMAZ, E., AĞAOĞLU, L., DEVECİOĞLU, Ö., YALMAN, N., GEDİKOĞLU, G. (2000). Prognostic significance of Wilms tumor 1 gene in childhood acute lymphoblastic leukemia. Turkish Journal of Hematology, Cilt: 17 - Sayı: 4, 183–188. https://ajindex.com/articles/413455

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