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Journals / Turkish Journal of Hematology / 2007 / Cilt: 24 - Sayı: 1

Akut lösemili çocuklarda geç endokrin yan etkiler

Late endocrine side effects in children with acute leukemia

Mustafa BÜYÜKAVCI
Nazan ÇETİNGÜL
Şükran DARCAN
Mehmet KANTAR
Kaan KAVAKLI
Pages
8–13
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

TSH response to TRH test was exaggerated in 1 and blunted in 3 patients.

📌 3 Key Takeaways

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Objective & Hypothesis:This study was carried out in 28 patients (10 female, 18 male) diagnosed with acute leukemia, and aimed to investigate the abnormalities of endocrine system.
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Key Findings & Data:Twenty-five of 28 patients were acute lymphoblastic leukemia and 3 were acute non-lymphocytic leukemia.
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Conclusion & Impact:TSH response to TRH test was exaggerated in 1 and blunted in 3 patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Öncül hücre lenfoblastik lösemi-lenfoma · Çocuk · Lösemi

Abstract

This study was carried out in 28 patients (10 female, 18 male) diagnosed with acute leukemia, and aimed to investigate the abnormalities of endocrine system. Twenty-five of 28 patients were acute lymphoblastic leukemia and 3 were acute non-lymphocytic leukemia. Sixteen children were treated using BFM-90 chemotherapy protocol, and the rest with various regimens. Two patients were exposed to 12-13 Gy of total body irradiation followed by bone marrow transplantation. All patients were in remission at least five years. One (3%) of 28 patients had short stature and 4 (14%) had obesity. Pubertal status was retarded in 2 (7%) patients. Glucose intolerance, secondary hypothyroidism and hypergonadotropic hypogonadism were detected in 2, 1 and 2 patients, respectively. TSH response to TRH test was exaggerated in 1 and blunted in 3 patients.

Özet

Bu çalışmaya akut lösemi tanısı almış ve en az 5 yıldır remisyonda olan 28 hasta (10 kız, 18 erkek) dahil edildi ve bu olgularda endokrin yan etkiler araştırıldı. Yirmibeş hasta akut lenfoblastik lösemi, 3 hasta akut non-lenfositik lösemi tanısı almıştı. Onaltı çocuğun tedavisinde BFM-90 tadavi protokolü kullanılırken diğerleri farklı tedavi rejimleri aldılar. İki hastaya 12-13 Gy total vücut ışınlaması sonrası kemik iliği transplantasyonu uygulandı. Yirmisekiz hastadan birinde (%3) boy kısalığı, dördünde (%14) obezite mevcuttu. Hastaların ikisinde (%7) gecikmiş puberte, ikisinde glukoz intoleransı, birinde sekonder hipotroidizm ve ikisinde de hipergonadotropik hipogonadizm saptandı. Bir olguda TRH testine abartılı TSH yanıtı, 3 olguda baskılanmış yanıt gözlendi

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Cite This Article

BÜYÜKAVCI, M., ÇETİNGÜL, N., DARCAN, Ş., KANTAR, M., KAVAKLI, K. (2007). Akut lösemili çocuklarda geç endokrin yan etkiler. Turkish Journal of Hematology, Cilt: 24 - Sayı: 1, 8–13. https://ajindex.com/articles/413030

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