In conclusion, infliximab should be considered as a reliableoption for vascular Behçet’s Disease resistant to conventional treatment.
📌 3 Key Takeaways
🎯
Objective & Hypothesis:Cardiac involvement is an uncommon and life-threatening complication ofBehçet’s Disease.
📊
Key Findings & Data:We present a 14-year-old boy, admitted to our hospital forrecurrent hemoptysis.
💡
Conclusion & Impact:In conclusion, infliximab should be considered as a reliableoption for vascular Behçet’s Disease resistant to conventional treatment.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Özet
Cardiac involvement is an uncommon and life-threatening complication ofBehçet’s Disease. We present a 14-year-old boy, admitted to our hospital forrecurrent hemoptysis. In his radiologic evaluation, a right ventricular thrombusand pulmonary arterial aneurysm were identified. He was diagnosed withBehçet’s Disease, and then he received prednisone and cyclophosphamide.However, his cardiac thrombus enlargened. After his treatment was replacedwith infliximab, the pulmonary aneurysms regressed, and the cardiac thrombusdisappeared. In conclusion, infliximab should be considered as a reliableoption for vascular Behçet’s Disease resistant to conventional treatment.
🔖
Cite This Article
ISIYEL, E., BAKKALOĞLU, S., OĞUZ, D., YENİCESU, İ., BOYUNAĞA, Ö., ÖZDEMİR, Y., DAMAR, Ç., KANDUR, Y., AKÇABOY, M., ASLAN, A. T., ŞİŞMANLAR, T., HASANOĞLU, E., BUYAN, N. (2019). An adolescent case of extensive Behçet’s disease successfully treated with Infliximab. Turkish Journal of Pediatrics, Cilt: 61 - Sayı: 4, 585–588. https://ajindex.com/articles/412026
Wirth M, Jellimann JM, Jellimann S, Hascoet JM. Darie C, Knezinsky M, Demolombe-Rague S, et al. Cardiac pseudotumor revealing Behcet's disease. Rev Med Interne 2005; 26: 420-424
Hatemi G, Seyahi E, Fresko I, Talarico R, Hamuryudan V. Behcet's syndrome: A critical digest of the 2014- 2015 literature. Clin Exp Rheumatol 2015; 33(6 Suppl 94): S3-S14
Koné-Paut I, Shahram F, Darce-Bello M, et al; PEDBD Group. Consensus classification criteria for paediatric Behçet's disease from a prospective observational cohort: PEDBD. Ann Rheum Dis 2016;75: 958-964 4. Koc Y, Gullu I, Akpek G, et al. Vascular involvement in Behcet's disease. J Rheumatol 1992; 19: 402-410
Mutlu S, Scully C. The person behind the eponym: Hulusi Behcet (1889-1948). J Oral Pathol Med 1994; 23: 289-290
Criteria for diagnosis of Behcet's disease. International Study Group for Behcet's Disease. Lancet 1990; 335: 1078-1080
Ames PRJ, Steuer A, Pap A, Denman AM. Thrombosis in Behcet's disease: A retrospective survey from a single UK centre. Rheumatology (Oxford) 2001; 40: 652-655
Louali FE, Tamdy A, Soufiani A, et al. Cardiac thrombosis as manifestation of Behçet syndrome. Tex Heart Inst J 2010; 37: 568-571
Gopathi S, Hurt RT, Guardiola J. Intracardiac thrombus in Behçet’s disease: A rare case in the United States. Respir Med CME 2011; 4: 154-156
Marc K, Iraqui G, Jniene A, Benamor J, Bourkadi JE. Intracardiac thrombus and pulmonary artery aneurysm in Behcet's disease. Rev Mal Respir 2008; 25: 69-72
Noureddine M, Charei N, Drighil A, Chraibi N. Right intracardiac thrombus in Behcet's disease. Arch Mal Coeur Vaiss 2004; 97: 925-928
Aksu T, Tufekcioglu O. Intracardiac thrombus in Behçet's disease: Four new cases and a comprehensive literature review. Rheumatol Int 2015; 35: 1269- 1279
Seyahi E, Melikoglu M, Akman C, et al. Pulmonary artery involvement and associated lung disease in Behçet disease: A series of 47 patients. Medicine (Baltimore) 2012; 9: 35-48
Hammami R, Abid L, Frikha F, et al. Intracardiac thrombus in a young man: Don't forget Behcet's disease! Intern Med 2012; 51: 1865-1867
Demirelli S, Degirmenci H, Inci S, Arisoy A. Cardiac manifestations in Behcet's disease. Intractable Rare Dis Res 2015; 4: 70-75
Hatemi G, Silman A, Bang D, et al. Management of Behcet disease: A systematic literature review for the European League Against Rheumatism evidencebased recommendations for the management of Behcet disease. Ann Rheum Dis 2009