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Journals / Turkish Journal of Gastroenterology / 2000 / Cilt: 11 - Sayı: 3

Gastrointestinal sistem tutulumuyla birlikte sistemik amiloidozis: 93 vakanın histolojik özellikleri

Systemic amyloidosis with gastrointestinal tract involvement: Histologic features of 93 cases

Banu BİLEZİKÇİ
Beyhan DEMİRHAN
Asuman N. HABERAL
Sedat BOYACIOĞLU
Yücel GÜNGEN
Pages
244–248
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusions: Our findings can be explained by the short average duration of hemodialysis given to patients and the predominance of endoscopic biopsy samples in our study.

📌 3 Key Takeaways

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Objective & Hypothesis:Background/aims: Systemic amyloidosis is not a single disease, but the product of a variety of diseases.
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Key Findings & Data:This article describes the amyloid deposits in gastrointestinal tissues of 93 patients undergoing hemodialysis.
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Conclusion & Impact:Conclusions: Our findings can be explained by the short average duration of hemodialysis given to patients and the predominance of endoscopic biopsy samples in our study.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Amiloidoz · Gastrointestinal hastalıklar · Sınıflandırma

Abstract

Background/aims: Systemic amyloidosis is not a single disease, but the product of a variety of diseases. Gastrointestinal tract involvement is common, and all parts of the system may be affected. Systemic amyloidosis can also cause pancreatic and hepatic disease. Histologic examination is essential for definitive diagnosis of amyloidosis. This article describes the amyloid deposits in gastrointestinal tissues of 93 patients undergoing hemodialysis. Methods: A total of 111 endoscopic samples, 22 needle biopsy samples, two appendectomy and one jejunal resection specimens were examined using immunohistochemical analysis. Immunohistochemical classification using a panel of antisera directed against five major amyloid fibril proteins (AA amyloid, $\beta$2-microglobulin, transthyretin, kappa, and lambda) enabled us to identify at least four different types of amyloid. Results: All of the samples exhibited protein of AA amyloid origin, but no $\beta$2 microglobulin amyloid. Conclusions: Our findings can be explained by the short average duration of hemodialysis given to patients and the predominance of endoscopic biopsy samples in our study.

Özet

Amaç: Sistemik amiloidozis tek bir hastalık olmayıp çeşitli patolojilerin bir ürünüdür. Gastrointestinal kanalın tutulumu sık olup herhangi bir bölümü etkilenebilir. Sistemik amiloidozis pankreatik ve hepatik hastalıklara da neden olabilir. Amiloidozisin kesin tanısı için histolojik inceleme esastır. Yöntem: Bu makalede 93 hastaya ait gastrointestinal dokuda amiloid birikimi tanımlanmaktadır. 111 endoskopik, 22 iğne biyopsisi, 2 apendektomi ve bir jejunal rezeksiyon spesmeni immünohistokimyasal yöntemle incelenmiştir. İmmünohistokimyasal sınıflamada 4 farklı amiloid tipine yönelik, 5 major amiloid antikoru (AA proteini, b2- mikroglobülin, transtiretin, kappa ve lambda) çalışılmıştır. Bulgular: Örneklerin hepsinin AA amiloid orijinli olduğu görülmüş, $\beta$2-mikroglobülin orijini saptanmamıştır. Sonuç: Bulgularımız hastaların hemodializ sürelerinin kısa oluşu ve çalışma grubumuzda endoskopik biyopsi sayısının çokluğu ile açıklanabilir.

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Cite This Article

BİLEZİKÇİ, B., DEMİRHAN, B., HABERAL, A. N., BOYACIOĞLU, S., GÜNGEN, Y. (2000). Gastrointestinal sistem tutulumuyla birlikte sistemik amiloidozis: 93 vakanın histolojik özellikleri. Turkish Journal of Gastroenterology, Cilt: 11 - Sayı: 3, 244–248. https://ajindex.com/articles/411270

References (1)

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