Journals / Turkish Journal of Gastroenterology / 2013 / Cilt: 24 - Sayı: 6

Ciddi akut pankreatit hastalarında akut akciğer hasarı

Acute lung injury in patients with severe acute pancreatitis

Pages
502–507
DOI
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Conclusion: Acute lung injury occurrence in patients with severe acute pancreatitis varies according to predisposing conditions and in dependently carries poor prognosis.

📌 3 Key Takeaways

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Objective & Hypothesis:Background/aims: Severe acute pancreatitis can result in acute lung injury.
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Key Findings & Data:Materials and Methods: We retrospectively evaluated 184 patients with severe acute pancreatitis admitted between April 2007 and July 2010.
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Conclusion & Impact:Conclusion: Acute lung injury occurrence in patients with severe acute pancreatitis varies according to predisposing conditions and in dependently carries poor prognosis.
🔬Design:Research Article
📍Scope:2007 Verileri
⚙️Variables:Domain Parameters

Abstract

Background/aims: Severe acute pancreatitis can result in acute lung injury. This study aims to investigate the clinical characteristics and possible prediction index of acute lung injury in severe acute pancreatitis. Materials and Methods: We retrospectively evaluated 184 patients with severe acute pancreatitis admitted between April 2007 and July 2010. There were 51 patients who de veloped acute lung injury with a rate of 27.7% (51/184). Clinical data of the acute lung injury and non-acute lung injury patients were compared, and the characteristics of acute lung injury were also analyzed. Meanwhile, we validated a few possible prediction indexes to identify the patients at high risk for acute lung injury at the time of hospital admission. Results: The severity index, hospital day, and the incidence of infectious complications were significantly higher in the acute lung injury patients than in the nonacute lung injury patients (p<0.05). The differences between the non-acute lung injury and acute lung injury groups in mortality(3% vs. 11.8%, p<0.05), operation (5.3% vs. 15.7%, p<0.05), and incidence of renal failure (15.8% vs. 33.3%, p<0.05), cardiovascu- lar failure (3.8% vs. 15.7%, p<0.05), and pancreatic cyst (18% vs. 37.3%, p<0.05) were statistically significant. The patients with higher level of severity index score, acidosis, tachypnea, smoking history, and obesity were prone to develop acute lung injury. Conclusion: Acute lung injury occurrence in patients with severe acute pancreatitis varies according to predisposing conditions and in dependently carries poor prognosis.

Özet

Giriş ve Amaç: Ciddi akut pankreatit, akut akci¤er hasarına neden olabilmektedir. Bu çalışmada ciddi akut pankreatitli hastalarda akut akciğer hasarının klinik özelliklerini araştrmak ve risk faktörlerini bulmak amaçlanmıştır. Gereç ve Yöntem: Nisan 2007\'den Temmuz 2010\'a kadar 184 ciddi akut pankreatitli hasta retrospektif olarak tespit edildi. Bunların 51 tanesinde (% 27.7) akut akciğer hasarı gelişmişti. Akut akciğer hasarı ve akut olmayan akciğer hasarı olan hastaların klinik özellikleri karşılaştırldı ve akut akciğer hasarının özellikleri ayrıca analiz edildi. Aynı zamanda hastaneye yatışta akut akciğer hasarı açısından prediktif indeks oluşturmak için validasyon çalışması yapıldı. Bulgular: Ciddiyet indeksi, yatış süresi ve infeksiyöz komplikasyon varlığı akut akciğer hasarı olan olgularda, akut olmayan akciğer hasarı olan olgulara göre daha fazla idi (p<0.05). Akut akciğer hasarı olan ve akut olmayan akciğer hasarı olan hastalarda mortalite (3% vs. 11.8%, p<0.05), operasyon (5.3% vs. 15.7%, p<0.05), ve böbrek yetmezliği insidansı (15.8% vs. 33.3%, p<0.05), kardiyovasküler yetmezlik (3.8% vs. 15.7%, p<0.05), pankreatik kist (18% vs.37.3%, p<0.05) aralarındaki farklar istatistiksel açıdan anlamlıydı. Sonuçlar: Ciddi akut pankreatitli olgularda akut akciğer hasarı gelişmesi altta yatan faktörlere göre değişmekte ve diğer faktörlerden bağımsız olarak kötü prognoz belirlemektedir.

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Cite This Article

LEI, H., MINGHAO, W., XIAONAN, Y., PING, X., ZIQI, L., QING, X. (2013). Ciddi akut pankreatit hastalarında akut akciğer hasarı. Turkish Journal of Gastroenterology, Cilt: 24 - Sayı: 6, 502–507. https://ajindex.com/articles/411089

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