Journals / Turkish Journal of Gastroenterology / 1999 / Cilt: 10 - Sayı: 4

Helicobacter pylori density in patients with nonulcer dyspepsia and patients with duodenal ulcer

Non-ülser dispepsili ve duodenal ülserli kişilerde Helicobacter pylori yoğunluğu

Pages
407–410
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It is concluded that there is no relationship between the H. pylori density of H. pylori(+) NUD and H. pylori (+) duodenal ulcer patients in our country.

📌 3 Key Takeaways

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Objective & Hypothesis:Gastric colonization with Helicobacter pylori (H. pylori) has been reported as a potential contributing factor in the pathogenesis of duodenal ulcer in 95% of patients.
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Key Findings & Data:Thirty four patients with H. pylori(+) duodenal ulcer and 34 patients with H. pylori(+) NUD were included in this study.
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Conclusion & Impact:It is concluded that there is no relationship between the H. pylori density of H. pylori(+) NUD and H. pylori (+) duodenal ulcer patients in our country.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Dispepsi · Gastrointestinal hastalıklar · Duodenum ülseri

Abstract

Gastric colonization with Helicobacter pylori (H. pylori) has been reported as a potential contributing factor in the pathogenesis of duodenal ulcer in 95% of patients. However, the role of H. pylori and associated chronic gastritis in causing dyspeptic symptoms in persons without peptic ulcer is uncertain. There are studies claiming that the clensity H. pylori in the gastric antrum of patients with duodenal ulcer is higher than in patients with nonulcer dyspepsia (NUD). In this prospective study, we aimed to investigate whether there is a difference in H. pylori density between patients with duodenal ulcer and NUD. Thirty four patients with H. pylori(+) duodenal ulcer and 34 patients with H. pylori(+) NUD were included in this study. In order to predict the density of H. pylori qualitatively, the brush material from both the antrum and corpus was examined cytologically, and the imprints and histological evaluation of the biopsy material was made by an experienced pathologist, with H. pylori density being scored. H. pylori density was found to be 1.89±0.87 in patients with NUD and 2.00±0.81 in patients with duodenal ulcer. When H. pylori densities of both study groups were compared, the difference was not statistically significant (p=0.71). It is concluded that there is no relationship between the H. pylori density of H. pylori(+) NUD and H. pylori (+) duodenal ulcer patients in our country.

Özet

Günümüzde duodenal ülserin etyolojisinde yaklaşık %95 oranında Helicobacter pylori' nin (H. pylori) etken olduğu kesin olarak bilinmektedir. Ancak Non-ülser dispepsideki (NUD) rolü halen kesin olarak bilinmemektedir. Duodenal ülserli kişilerde mide antrumunda H. pylori yoğunluğunun NUD kişilere göre daha fazla olduğunu iddia eden çalışmalar vardır. Bizde bu prospektif çalışma da ülkemizde H. pylori (+) duodenal ülserli hastalar ile yine H. pylori (+) NUD'li hastalar arasında H. pylori yoğunluğu açısından bir fark olup olmadığını araştırmayı amaçladık. Çalışmaya 34 H. pylori (+) duodenal ülserli ve 34 H. pylori (+) NUD hasta alındı. H. pylori yoğunluğunu kalitatif olarak saptamak için; antrumdan ve korpusdan alınan biyopsilerin imprint ve histolojik olarak incelenmesiyle birlikte sitolojik olarak da yine antrumdan ve korpusdan yapılan brush materyalinde H. pylori yoğunluğu tek bir patolog tarafından skorlandı. NUD'li hasta grubundaki H. pylori yoğunluğu 1.89 ± 0.87 olup duodenal ülserli hasta grubundaki H. pylori yoğunluğu ise 2.00 ± 0.81 olarak bulundu. Her iki grup arasındaki H. pylori yoğunluğu karşılaştırıldığında aralarındaki fark (p=0.71) istatistiki olarak anlamsız idi. Ülkemizde H. pylori (+) non-ülser dispepsili hastalarda ki H. pylori yoğunluğu ile duodenal ülserli H. pylori (+) hastalardaki H. pylori yoğunluğu arasında bir ilişki olmadığı kanaatine varılmıştır.

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Cite This Article

GÜREL, S., YERCİ, Ö., ADIM, B. Ş. (1999). Helicobacter pylori density in patients with nonulcer dyspepsia and patients with duodenal ulcer. Turkish Journal of Gastroenterology, Cilt: 10 - Sayı: 4, 407–410. https://ajindex.com/articles/410966

References (11)

  1. Bernersen B, Johnsen R, Bostad L, et al. Is H.pylori the cause of dyspepsia? BMJ 1992; 304: 1276-9
  2. The European H. pylori Study Group (EHPSG). Current European concepts in the management of H. pylori infection: The Maastricht Consensus report. Gut 1997; 41: 8-13
  3. Smoot DT, Mobley HLT, Lewison JF, Resau JH. H. pylori urease activity is toxic to human gastric epithelial cells. Infect Immun 1990; 58: 1992-4
  4. Khulusi S, Mendall MA, Patel P, et al. H. pylori infection density and gastric inflammation in duodenal ulcer and non-ulcer subjects. Gut 1995; 37:319-24
  5. Armstrong D. H. pylori infection and dyspepsia. Scan J Gastroenterol 1996; 31: 38-47
  6. Jones RH, Lydeard S. Prevalence of symptoms of dyspepsia in the community. BMJ 1989; 298: 30-2
  7. Talamini G, Zamboni G, Cavallini G. Antral mucosal H. pylori infection density as a risk factor of duodenal ulcer. Digestion 1997; 58: 211-7
  8. Dixon MF. Pathophysiology of Helicobacter pylori infection. Scan J Gastroenterol 1994; 29: 7-10
  9. Olbe L, Hamlet A, Dalenback J, Fandriks L. A mechanism by which H. pylori infection of the antrum contributes to the development of duodenal ulcer. Gastroenterology 1996; 110: 1386-94
  10. Alam K, Schubert TT, Bologna SD, Ma CK. Increased density of Helicobacter pylori on antral biopsy is associated with severity of acute and chronic inflammation and likelihood of duodenal ulceration. Am J Gastroenterol 1992; 87: 424-8
  11. Tokunaga Y, Hata K, Ryo J, et al. Density of Helicobacter pylori infection in patients with peptic ulcer perforation. J Am Coll Surg 1998; 186: 659-63.