AI Summary & Key Takeaways
AI InsightConclusions: These findings suggest that the influence of a traditional diet rich in nitrate and nitrite is significant in the development of endemic upper gastrointestinal (esophageal and gastric) cancers in the Van region of Turkey.
📌 3 Key Takeaways
Abstract
Background/aims: The aim of this study was investigate nitrate and nitrite levels in some traditional foods and drinking water in Van, an endemic upper gastrointestinal (esophageal and gastric) cancer region of Eastern Turkey. Methods: Cheese with added herbs, drinking water, bread baked by wood fire and bread baked by burning animal manure specimens collected in the Van region were analyzed by Stahr's modification method. Nitrite, was reduced to nitrate by the following three reagents: hydrazine sulphate ( (NH2) 2SO4), CuSO4 and NaOH. Nitrate was then determined by coupling reagent containing sulphanlyamide, phosphoric acid, and N-1-naphtyl ethylendiamine dihydrochloride. Results: Nitrate and, nitrite levels of all traditional foods and nitrite levels of drinking water were very significantly elevated compared to standard values (p<0.001-0.01). Conclusions: These findings suggest that the influence of a traditional diet rich in nitrate and nitrite is significant in the development of endemic upper gastrointestinal (esophageal and gastric) cancers in the Van region of Turkey.
Özet
Amaç: Endemik üst gastrointestinal (özofagus ve mide) kanser bölgesi olan Van'da sık olarak yenilen bazı geleneksel besinler ve içme suyunda, nitrat ve nitrit düzeyleri araştırılması amaçlanmıştır. Metod: Van bölgesinde otlu peynir, içme suyu, odun ateşi ve tezek ( hayvan atığı) ateşinde pişen ekmek örneklerinde nitrat ve nitrit düzeyleri Stahr modifikasyon yöntemi ile ölçüldü. Nitritin nitrata indirgenme işlemi hydrazine sulphate ((NH2) 2SO4, CuSO4 and NaOH gibi, üç ayıraç ile yapıldı. Daha sonra, nitrat düzeyleri sulphanlyamid, phosphoric acid ve N-1-naphtyl ethylendiamin dihydrochloride içeren indirgeyici ayıraç ile belirlendi. Bulgular: Tüm geleneksel besinlerde nitrat ve nitrit düzeyleri, içme suyunda ise nitrit düzeyleri kontrol değerlerine göre ileri derecede anlamlı yüksek bulundu (p<0.001- 0.01). Sonuç: Bu bulgular Van bölgesinde nitrat ve nitritden zengin geleneksel diyetin üst gastrointestinal (özofagus ve mide) kanserlerin gelişmesinde önemli rolünü ortaya koymaktadır.