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Journals / Turkish Journal of Gastroenterology / 1999 / Cilt: 10 - Sayı: 3

Nitric oxide oxidation products in the serum of patients with gastric and esophageal cancer and Helicobacter pylori

Mide ve özofagus kanserlerinde serum nitrik oksit oksidasyon ürünleri ve Helicobacter pylori

M. Kürşad TÜRKDOĞAN
Haluk TESTERECİ
TAHİR KAHRAMAN
F. Hüsniye DİLEK
Emel AKMAN
Pages
193–196
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, we observed the highest serum NO product levels in the gastric Ca group although the dietary intake of nitrated foods was similar in both of the Ca groups.

📌 3 Key Takeaways

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Objective & Hypothesis:Nitric oxide (NO) oxidation products (nitrate and nitrite) were analysed in the serum of 12 gastric cancer (Ca), (12 gastric Ca, 12 esophageal Ca) and 12 healthy controls with modified Stahr's method.
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Key Findings & Data:In the gastric Ca group mean, serum nitrate and nitrite levels (11.65 ppm and 3.40 ppm) were significantly higher than the esophageal Ca and control groups ( p<0.05 and p<0.001).
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Conclusion & Impact:In conclusion, we observed the highest serum NO product levels in the gastric Ca group although the dietary intake of nitrated foods was similar in both of the Ca groups.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Özofagus neoplazmları · Mide neoplazmları · Helicobacter pylori

Abstract

Nitric oxide (NO) oxidation products (nitrate and nitrite) were analysed in the serum of 12 gastric cancer (Ca), (12 gastric Ca, 12 esophageal Ca) and 12 healthy controls with modified Stahr's method. Helicobacter pylori (H. pylori) infection was diagnosed histopathologically in the gastric cancer and control groups. In the gastric Ca group mean, serum nitrate and nitrite levels (11.65 ppm and 3.40 ppm) were significantly higher than the esophageal Ca and control groups ( p<0.05 and p<0.001). In the esophageal Ca group the mean serum nitrate level (7.16 ppm) was higher than the control group (4.73 ppm, p<0.05) while the nitrite level (1.53 ppm) was not significantly different from the control group (1.70 ppm). H. pylori infection was significantly higher in the gastric Ca group (56.40 %) than the control group (36.66 %, p<0.05). In conclusion, we observed the highest serum NO product levels in the gastric Ca group although the dietary intake of nitrated foods was similar in both of the Ca groups. This observation indicates the important role of H. pylori infection in the etiopathogenesis of gastric cancer related to the synthesis of NO and consequent the carcinogen nitroso compounds.

Özet

Mide ve özofagus kanser (Ca) 'li 24 hasta ile sa¤lıklı 12 kişide serum nitrik oksit (NO) oksidasyon ürünleri (nitrat ve nitrit) modifiye Stahr yöntemi ve coupling ayıracı ile ölçüldü. Helicobacter pylori (H. pylori) infeksiyonu Mide Ca ve kontrol grublarında histopatolojik yöntemle de¤erlendirildi. Mide Ca grubunda serum nitrat ve nitrit düzeyleri (11.65 ppm ve 3.40 ppm) özofagus Ca ve kontrol gruplarına göre anlamlı yüksekti (p<0.05 ve p<0.001). Özofagus Ca grubunda serum nitrat düzeyi artmış (7.16 ppm, p<0.05), nitrit düzeyi (1.53 ppm) ise kontrol grubuna göre (1.70 ppm) farklı de¤ildi. Mide Ca grubunda H. pylori infeksiyonu (% 56.40) kontrol grubuna (%36.66) göre anlamlı yüksekti (p<0.05). Sonuç olarak, diyetle nitrat alımı benzer ölçüde olan her iki Ca grubundan mide Ca grubunda NO oksidasyon ürünlerinin H. pylori infeksiyonu ile birlikte anlamlı yüksekli¤i H. pylori'nin NO sentezi ve karsinojen nitrozo bileşiklerinin gelişmesindeki rolünü düşündürmektedir.

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Cite This Article

TÜRKDOĞAN, M. K., TESTERECİ, H., KAHRAMAN, T., DİLEK, F. H., AKMAN, E. (1999). Nitric oxide oxidation products in the serum of patients with gastric and esophageal cancer and Helicobacter pylori. Turkish Journal of Gastroenterology, Cilt: 10 - Sayı: 3, 193–196. https://ajindex.com/articles/410547

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