Journals / Turkish Journal of Gastroenterology / 1999 / Cilt: 10 - Sayı: 4

Portal colopathy findings in patients with liver cirrhosis

Karaciğer sirozlu hastalarda portal kolopati bulguları

Pages
328–333
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Since the colonic lesions, although usually asymptomatic and clinically insignificant, are a potential source of acute or chronic lower GI bleeding, further investigation is needed to reduce the risk of bleeding and offer alternative treatment models.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Portal hypertension diffusely affects the gastrointestinal (GI) tract.
📊
Key Findings & Data:In this study, colonoscopic findings, upper GI endoscopy, portal system colored Doppler ultrasonographic results and the degree of liver dysfunction were prospectively investigated among 25 hae-modynamically stable patients with postviral cirrhosis without a history of bleeding.
💡
Conclusion & Impact:Since the colonic lesions, although usually asymptomatic and clinically insignificant, are a potential source of acute or chronic lower GI bleeding, further investigation is needed to reduce the risk of bleeding and offer alternative treatment models.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Özofageal ve gastrik varisler · Kolon hastalıkları · Hipertansiyon

Abstract

Portal hypertension diffusely affects the gastrointestinal (GI) tract. Portal colopathy is a new clinical entity with liver cirrhosis but the frequency and profile of distinct colonic mucosal lesions (portal colopathy ) and rectal varices has been little studied in patients with liver cirrhosis. In this study, colonoscopic findings, upper GI endoscopy, portal system colored Doppler ultrasonographic results and the degree of liver dysfunction were prospectively investigated among 25 hae-modynamically stable patients with postviral cirrhosis without a history of bleeding. We found the incidence of esophageal varices to be 96%, congestive gastropathy 20% and portal colopathy excluding anorectal varices and hemorrhoids 92% in our patients. Portal colopathic lesions were occasionally localized in the rectosigmoid area, ascending colon, anal canal and transverse colon. The degree of esophageal varices was associated with congestive colopathy but not with anorectal varices and hemorrhoids. While congestive gastropathy had no significant relationship with esophageal varices , congestive colopathy was present in all patients with congestive gastropathy. However, no association was evident between these lesions and the degree of disease severity. Additional studies are required not only to determine the frequency of this entity, but also to understand the pathophysiology of these lesions. Since the colonic lesions, although usually asymptomatic and clinically insignificant, are a potential source of acute or chronic lower GI bleeding, further investigation is needed to reduce the risk of bleeding and offer alternative treatment models.

Özet

Portal hipertansiyon diffüz olarak gastrointestinal kanalı etkilemektedir. Portal kolopati, karaciğer sirozlu olgularda portal hipertansiyon sonucu gelişen yeni bir klinik antitedir. Ancak, karaciğer sirozlu hastalarda portal kolopati sıklığı ve özellikleri ile rektal varisler iyi çalışılmamıştır. Bu çalışmada, hemodinamik açıdan stabl olan ve kanama öyküsü olmayan 25 postnekrotik karaciğer sirozlu hastada, özefagoskopi, kolonoskopi ve renkli Doppler ultrasonografi yapılarak portal kolopati sıklığı, portal gastropati ve karaciğer hasarının derecesi ile ilişkisi araştırıldı, Çalışmamızda, karaciğer sirozlu olgularda özefagus varisleri % 96, konjestif gastropati % 20, anorektal varis ve hemoroid dışı konjestif kolopati lezyonları % 92 oranında tespit edildi. Portal kolopati lezyonları sıklıkla rektosigmoid bölge, inen kolon, anal kanal ve daha az oranda transvers kolonda idi. Özefagus varisi derecesi arttıkça konjestif kolopati görülme sıklığı artarken, anorektal varis ve hemoroid sıklığında artış görülmedi. Konjestif gastropati, özefagus varisleri ile anlamlı ilişki göstermezken, konjestif gastropatisi olan olguların hepsinde konjestif kolopati bulundu. Ancak bu lezyonlar ile Child skoru arasında anlamlılık görülmedi. Yapılacak çalışmaların, bu klinik antitenin yalnız sıklığının araştırılmasına yönelik değil, aynı zamanda patofizyolojisinin de incelenerek, bu lezyonların potansiyel kanama riskini azaltmak ve tedavi seçenekleri oluşturmak amacına yönelik olması gerektiği kanaatindeyiz.

🔖

Cite This Article

GÖRAL, V., KIZILAY, E., YÜKSELEN, V., DURSUN, M., ARAS, N., CANORUÇ, F., BÜYÜKBAYRAM, H. (1999). Portal colopathy findings in patients with liver cirrhosis. Turkish Journal of Gastroenterology, Cilt: 10 - Sayı: 4, 328–333. https://ajindex.com/articles/410537

References (17)

  1. Sherlock S. The portal venous system and portal hypertension. In: Disease of The Liver and Biliary System. 1993, 132-73
  2. Göral V, Canoruç F, Yıldız K, Çolakoğlu E. Endoscopic varices according to Japanese description in cirrhosis. Gastroenterology 1992; 2: 580-3
  3. Iwao T, Toyonaga A, Sumino M et al. Portal hypertensive gastropathy in patients with cirrhosis. Gastroenterology 1992; 102: 2060-5
  4. McCormack TT, Sims J, Eyre-Brook I, et al. Gastric lesions in portal hypertension: inflamatory gastritis or congestive gastropathy? GUT 1985; 26: 1226- 5) Papazian A, Bralion A, Dupus JL, et al. Portal hypertensive gastric mucosa: an endoscopic study. Gut 1986; 27: 1199-203
  5. Goenka MK, Kochar R, Nagi B, Mehta BK. Rectosigmoid varices and other mucosal changes in patients with portal hypertension. Am J Gastroenterol 1991; 86: 1185-9
  6. Ganguly S, Sarin SK, Bhatia V, Lahoti D. The prevalence and spectrum of colonic lesions in patients with cirrhotic and noncirrhotic portal hypertension. Hepatology 1995; 21: 1226-31
  7. Rabinovitz M, Schade RR, et al. Colonic disease in cirrhosis. Gastroenterology 1990; 99: 195-9
  8. Kozarek RA, Botoman VA, Bredfeldt Je, et al. Prospective study of colonoscopy in patients with portal hypertension. Gastroenterology 1991; 101: 1192-7
  9. Bresci G, Gambardella L, Paris G, et al. Colonic disease in cirrhotic patients with portal hypertension: an endoscopic and clinical evaluation. J Clin Gastroenterol 1998; 26: 220-7
  10. Chen LS, Lin HC, Lee FY, et al. Portal hypertensive colopathy in patients with cirrhosis. Scand J Gastroenterol 1996; 31: 490-4
  11. Yamakada S, Kanazawa H, Kobayashi M. Portal hypertensive colopathy; endoscopic findings and the relation to portal pressure. Intern Med 1995; 34: 153-7
  12. Tam TN, Lee SD. Colonic mucosal changes in patients with liver cirrhosis. Gastrointest Endosc 1995; 42: 408-12
  13. Cales P, Zabotto B, Meskens et al. Gastroesophageal endoscopic features in cirrhosis. Gastroenterology 1110; 98: 156-62
  14. Rabinovitz M, Schade RR, et al. Colonic disease in cirrhosis. Gastroenterology 1990; 99: 195-9
  15. McCormack TT, Sims J, Eyre-Brook I, et al. Gastric lesions in portal hypertension: inflamatory gastritis or congestive gastropathy ? Gut 1985; 26:1226-32
  16. Sarıçam T, Bahar K, Uzunalimoğlu Ö, Salih M. Portal hipertansiyonda gastrointestinal mukozal değişiklikler. Gastroenteroloji 1993; 4: 463-7
  17. Misra SP, Dwivedi M, Misra V. Prevalence and factors influencing hemorrhoids, anorec