AI Summary & Key Takeaways
AI InsightIn patients with various benign stomach lesions, the presence of Helicobacter pylori does not seem to affect serum ghrelin levels.
📌 3 Key Takeaways
Abstract
Background/aims: Ghrelin is a 28 amino acid peptide and the main source of serum ghrelin is the stomach. The aim of this study was to evaluate serum ghrelin levels in patients with hyperplastic gastric polyp. Materials and Methods: Eighty patients (50 female, 30 male) were included in this study: 28 with hyperplastic gastric polyp, 20 with benign gastric ulcer and 32 with chronic active gastritis. Serum ghrelin levels were measured by radioimmunoassay method. Results: Serum ghrelin level was significantly lower in patients with hyperplastic gastric polyp (1139.86±279.23 pg/ml) than in those with benign gastric ulcer (1362.45±335.35 pg/ml) and chronic active gastritis (1362.91±269.67 pg/ml) (p=0.016 and p=0.003, respectively). The benign gastric ulcer and chronic active gastritis groups had similar serum values (p=0.996). Serum ghrelin level was not affected by Helicobacter pylori, with levels of 1298.70±309.01 pg/ml and 1252.12±303.04 pg/ml in 56 positive and 24 negative patients, respectively (p=0.536). In the patients with hyperplastic gastric polyp, Helicobacter pylori infection was found to have no effect on serum ghrelin level (p=0.855). Conclusions: Serum ghrelin levels of patients with hyperplastic gastric polyp were lower than in patients with benign gastric ulcer and chronic active gastritis. In patients with various benign stomach lesions, the presence of Helicobacter pylori does not seem to affect serum ghrelin levels.
Özet
Amaç: Ghrelin 28 amino asit peptiddir ve dolaşımdaki ghrelinin ana kaynağı midedir. Bu çalışmanın amacı hiperplastik mide polipli hastalardaki serum ghrelin seviyesini değerlendirmekti. Gereç ve Yöntem: Çalışmaya 80 (50 kadın/30 erkek) hasta dahil edildi. Hasta gruplarının dağılımı; 28 hiperplastik mide polipli hasta, 20 benign mide ülserli hasta ve 32 kronik nonatrofik gastritli hasta idi. Serum ghrelin seviyesi radyoimmun test yöntemi ile ölçüldü. Bulgular: Serum ghrelin düzeyi hiperplastik mide polipli hastalarda (1139.86±279.23 pg/ml), benign mide ülserli (1362.45±335.35 pg/ml) ve kronik aktif gastritli hastalara (1362.91±269.67 pg/ml) göre anlamlı düzeyde düşüktü (P=0.016 ve P=0.003). Benign mide ülserli ve kronik aktif gastritli grup arası nda fark yoktu (P=0.996). Serum ghrelin seviyeleri Helikobakter pilori pozitif hastalarda (56 hasta) 1298.70±309.01 pg/ml ve Helikobakter pilori negatif hastalarda (24 hasta) 1252.12±303.04 pg/ml saptandı ve sonuç anlamlı değildi (P=0.536). Hiperplastik mide polipli hastalarda Helikobakter pilori varlığının serum ghrelin seviyesine etkili olmadığı saptandı (P=0.855). Sonuç: Hiperplastik mide polipli hastalardaki serum ghrelin seviyesi benign mide ülserli ve kronik nonatrofik gastritli hastaların serum ghrelin seviyesinden daha düşüktü. Çeşitli benign mide lezyonlarına sahip hastalarda Helikobakter pilori varlığının serum ghrelin düzeylerine etkisi görülmüyor.