Journals / Turkish Journal of Gastroenterology / 2017 / Cilt: 28 - Sayı: 1

Does the treatment of proton pump inhibitors reduce dysplasia or adenocarcinoma development in Barrett's esophagus?

Pages
41–42
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Therefore, treatments with PPI may be considered in patients with a diagnosis of BE and at a high risk of adenocarcinoma, even though they are not symptomatic

📌 3 Key Takeaways

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Objective & Hypothesis:Besides reducing the reflux symptoms, the benefit of proton pump inhibitors (PPI) in the treatment of Barrett's esophagus (BE) is not exactly known.
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Key Findings & Data:The data in the literature show that although the PPI treatment does not reduce the Barrett's segment length, it can reduce dysplasia or the development of early-stage adenocarcinoma (odds ratio (OR): 0.46).
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Conclusion & Impact:Therefore, treatments with PPI may be considered in patients with a diagnosis of BE and at a high risk of adenocarcinoma, even though they are not symptomatic
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Besides reducing the reflux symptoms, the benefit of proton pump inhibitors (PPI) in the treatment of Barrett's esophagus (BE) is not exactly known. The data in the literature show that although the PPI treatment does not reduce the Barrett's segment length, it can reduce dysplasia or the development of early-stage adenocarcinoma (odds ratio (OR): 0.46). Therefore, treatments with PPI may be considered in patients with a diagnosis of BE and at a high risk of adenocarcinoma, even though they are not symptomatic

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Cite This Article

AKIN, H., AYDIN, Y. (2017). Does the treatment of proton pump inhibitors reduce dysplasia or adenocarcinoma development in Barrett's esophagus?. Turkish Journal of Gastroenterology, Cilt: 28 - Sayı: 1, 41–42. https://ajindex.com/articles/410214

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References (3)

  1. Weinstein WM, Lieberman DA, Lewin KJ, et al. Omeprazole-induced regression of Barrett's esophagus: a 2 year, randomized, controlled double blind trial. Gastroenterology 110: A294
  2. Peters FT, Ganesh S, Kuipers EJ, Sluiter WJ, KlinkenbergKnol EC, et al. Endoscopic regression of Barrett's oesophagus during omeprazole treatment; a randomised double blind study. Gut 1999; 45: 489-94. [CrossRef] 3. Caldwell MTP, Byrne PJ, Walsh TN, et al. A randomised trial on the effect of acid suppression on regression of Barrett's oesophagus. Gastroenterology 1996; 110: A74
  3. Singh S, Garg SK, Singh PP, et al. Acid-suppressive medications and risk of oesophageal adenocarcinoma in patients with Barrett's oesophagus: a systematic review and meta-analysis. Gut 2014; 63: 1229-37. [CrossRef] 5. Hvid-Jensen F, Pedersen L, Funch-Jensen P, Drewes AM. Proton pump inhibitor use may not prevent high-grade dysplasia and oesophageal adenocarcinoma in Barrett's oesophagus: a nationwide study of 9883 patients. Aliment Pharmacol Ther 2014; 39: 984-91. [CrossRef] 6. Aydin Y, Akin H. Letter: proton pump inhibitor usage still seems to reduce the risk of high-grade dysplasia and/or oesophageal adenocarcinoma in Barrett's oesophagus. Aliment Pharmacol Ther 2014; 40: 859-60. [CrossRef]