Journals / Turkish Journal of Gastroenterology / 2018 / Cilt: 29 - Sayı: 6

Relationship between the neutrophil-to-lymphocyte ratio in acute pancreatitis and the severity and systemic complications of the disease

Pages
684–691
DOI
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⚡ TL;DR(Too Long; Didn't Read)

We also regard NLR as a valuable parameter for predicting thedevelopment of systemic complications in patients with AP.

📌 3 Key Takeaways

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Objective & Hypothesis:Background/Aims: In 80% of the patients, Acute pancreatitis (AP) occurs as a self-limiting disease that does not require any specifictreatment; however, in 20% of the cases it occurs in its clinically severe form that may lead to local or systemic complications.
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Key Findings & Data:The aimof this prospective study was to examine the relationship between the neutrophil to lymphocyte ratio (NLR) and the systemic complications and severity of AP.Materials and Methods: This prospective study included 100 patients with AP.
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Conclusion & Impact:We also regard NLR as a valuable parameter for predicting thedevelopment of systemic complications in patients with AP.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Background/Aims: In 80% of the patients, Acute pancreatitis (AP) occurs as a self-limiting disease that does not require any specifictreatment; however, in 20% of the cases it occurs in its clinically severe form that may lead to local or systemic complications. The aimof this prospective study was to examine the relationship between the neutrophil to lymphocyte ratio (NLR) and the systemic complications and severity of AP.Materials and Methods: This prospective study included 100 patients with AP. Age, sex, NLR, Ranson scores and the revised Atlantaclassification of the patients were recorded. The patients were divided into two groups according to the Ranson scores as mild andsevere AP. According to the Revised Atlanta classification, the patients were divided into two groups as mild and moderate+severe AP.Results: According to the Ranson score, NLR at the time of admission and at the 48th hour in the severe group was found to be statistically higher than the mild AP group (p 7.13.Conclusion: Neutrophil to lymphocyte ratio is associated with severe AP. We also regard NLR as a valuable parameter for predicting thedevelopment of systemic complications in patients with AP.

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Cite This Article

KOKULU, K., GÜNAYDIN, Y. K., AKILLI, N. B., KÖYLÜ, R., SERT, E. T., KÖYLÜ, Ö., CANDER, B. (2018). Relationship between the neutrophil-to-lymphocyte ratio in acute pancreatitis and the severity and systemic complications of the disease. Turkish Journal of Gastroenterology, Cilt: 29 - Sayı: 6, 684–691. https://ajindex.com/articles/410130

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References (2)

  1. Banks PA, Freeman ML. Practice guidelines in acute pancreatitis. Am J Gastroenterol 2006; 101: 2379-400. [CrossRef] Pandol SJ, Saluja AK, Imrie CW, Banks PA. Acute pancreatitis: bench to the bedside. Gastroenterology 2007; 132: 1127-51. [CrossRef] Bollen TL, Van Santvoort HC, Besselink MG, et al. The Atlanta Classification of acute pancreatitis revisited. Br J Surg 2008; 95: 6-21. [CrossRef] Peery AF, Dellon ES, Lund J, et al. Burden of gastrointestinal disease in the United States: 2012 update. Gastroenterology 2012; 143: 1179-87. [CrossRef] Forsmark CE, Baillie J. AGA Institute technical review on acute pancreatitis. Gastroenterology 2007; 132: 2022-44. [CrossRef] Bülbüller N, Doğru O, Ayten R, Akbulut H, İlhan YS, Çetinkaya Z. Procalcitonin is a predictive marker for severe acute pancreatitis. Ulus Travma Acil Cerrahi Derg 2006; 12: 115-20.
  2. Gibson PH, Cuthbertson BH, Croal BL, et al. Usefulness of neutrophil to lymphocyte ratio as predictor of new onset atrial fibrillation after coronary artery bypass grafting. Am J Cardiol 2010; 105: 186-91. [CrossRef] Yamanaka T, Matsumoto S, Teramukai S, Ishiwata R, Nagai Y, Fukushima M. The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in advanced gastric cancer. Oncology 2007; 73: 215-20. [CrossRef] Suppiah A, Malde D, Arab T, et al. The prognostic value of the neutrophil- lymphocyte ratio (NLR) in acute pancreatitis: identification of an optimal NLR. J Gastrointest Surg 2013; 17: 675-81. [CrossRef] Akıllı NB, Yortanlı M, Mutlu H, et al. Prognostic importance of neutrophil-lymphocyte ratio in critically ill patients: short-and longterm outcomes. Am J Emerg Med 2014; 32: 1476-80. [CrossRef] Banks PA, Bollen TL, Dervenis C, et al. Acute Pancreatitis Classification Working Group. Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus. Gut 2012; 62: 102-11. [CrossRef] Papachristou GI, Clermont G, Sharma A, Yadav D, Whitcomb DC. Risk and markers of severe acute pancreatitis. Gastroenterol Clin North Am 2007;36: 277-96. [CrossRef] Felderbauer P, Muller C, Bulut K, et al. Pathophysiology and treatment of acute pancreatitis: new therapeutic targets-a ray of hope. Basic Clin Pharmacol Toxicol 2005; 97: 342-50. [CrossRef] Wittel UA, Rau B, Gansauge F, et al. Influence of PMN leukocyte-mediated pancreatic damage on the systemic immune response in severe acute pancreatitis in rats. Dig Dis Sci 2004; 49: 1348-57. [CrossRef