In this review, we are going to summarizethe hitherto data in pathogenesis and would weigh the usefulnes and weaknes of each of existing scoring systemsin the management of AP.
📌 3 Key Takeaways
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Objective & Hypothesis:Acute pancreatitis (AP) constitutes the majority of cases requiring hospital admission in gastroenterology.
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Key Findings & Data:However our progress in the field was significant in the recent decade and a leap forward is expected inthis cumbersome-to-manage condition which has many unmet needs.
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Conclusion & Impact:In this review, we are going to summarizethe hitherto data in pathogenesis and would weigh the usefulnes and weaknes of each of existing scoring systemsin the management of AP.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Özet
Acute pancreatitis (AP) constitutes the majority of cases requiring hospital admission in gastroenterology. We areyet to know many things about its pathophysiology which is a certain drawback for the progress in its treatment.Prediction of severity is necessary for the plan of the management. The existing scoring systems are yet to be satisfactory. However our progress in the field was significant in the recent decade and a leap forward is expected inthis cumbersome-to-manage condition which has many unmet needs. In this review, we are going to summarizethe hitherto data in pathogenesis and would weigh the usefulnes and weaknes of each of existing scoring systemsin the management of AP.
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Cite This Article
İNCE, A. T., BAYSAL, B. (2014). Pathophysiology, classification and available guidelines of acute pancreatitis. Turkish Journal of Gastroenterology, Cilt: 25 - Sayı: 4, 351–357. https://ajindex.com/articles/409466
Gorelick FS, Thrower E. The acinar cell and early pancreatitis responses. Clin Gastroenterol Hepatol 2009; 7 (11 Suppl): S10-4. [CrossRef] 2. Lerch MM, Gorelick FS. Early trypsinogen activation in acute pancreatitis. Med Clin North Am 2000; 84: 549-63. [CrossRef] 3. Whitcomb DC. Genetic aspects of pancreatitis. Annu Rev Med 2010; 61: 413-24. [CrossRef] 4. Ji B, Gaiser S, Chen X, Ernst SA, Logsdon CD. Intracellular trypsin induces pancreatic acinar cell death but not NF-kappaB activation. J Biol Chem 2009; 284: 17488-98. [CrossRef] 5. Halangk W, Lerch MM, Brandt-Nedelev B, et al. Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. J Clin Invest 2000; 106: 773-81. [CrossRef] 6. Dawra R, Sah RP, Dudeja V, et al. Intra-acinar trypsinogen activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis. Gastroenterology 2011; 141: 2210-7. [CrossRef] 7. Awla D, Zetterqvist AV, Abdulla A, et al. NFATc3 regulates trypsinogen activation, neutrophil recruitment, and tissue damage in acute pancreatitis in mice. Gastroenterology 2012; 143: 1352-60. [CrossRef] 8. Archer H, Jura N, Keller J, Jacobson M, Bar-Sagi D. A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen. Gastroenterology 2006; 131: 1844-55. [CrossRef] 9. Whitcomb DC. Mechanisms of disease: Advances in understanding the mechanisms leading to chronic pancreatitis. Nat Clin Pract Gastroenterol Hepatol 2004; 1: 46-52. [CrossRef] 10. Sah RP, Garg P, Saluja AK. Pathogenic mechanisms of acute pancreatitis. Curr Opin Gastroenterol 2012; 28: 507-15. [CrossRef] 11. Chen X, Ji B, Han B, Ernst SA, Simeone D, Logsdon CD. NF-kappaB activation in pancreas induces pancreatic and systemic inflammatory response. Gastroenterology 2002; 122: 448-57. [CrossRef] 12. Zhang H1, Neuhöfer P, Song L, et al. IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality. J Clin Invest 2013; 123: 1019-31. [CrossRef] 13. Xue J, Nguyen DT, Habtezion A. Aryl hydrocarbon receptor regulates pancreatic IL-22 production and protects mice from acute pancreatitis. Gastroenterology 2012; 143: 1670-80. [CrossRef] 14. Muili KA, Wang D, Orabi AI, et al. Bile acids induce pancreatic acinar cell injury and pancreatitis by activating calcineurin. J Biol Chem 2013; 288: 570-80. [CrossRef] 15. Deitch EA. Multiple organ failure. Pathophysiology and potential future therapy. Ann Surg 1992; 216: 117-34. [Cr