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Journals / Turkish Journal of Gastroenterology / 2003 / Cilt: 14 - Sayı: 2

Kronik myeloid lösemili bir hastada sitoredüktif tedaviden sonra portal ven trombozu ve nonsirotik portal hipertansiyonun hızla kaybolması

Rapid resolution of portal vein thrombosis and noncirrhotic portal hypertension following cyto-reductive therapy in a patient with chronic myeloid leukemia

ALİ TÜZÜN İNCE
Cengiz BÖLÜKBAŞ
Remzi DALAY
Hacı Mehmet SÖKMEN
Oya Övünç KURDAŞ
İnci SÜLEYMANLAR
Fahri IŞITAN
Pages
141–144
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this report, etiopathogenetic factors of portal vein thrombosis and the role of cytoreductive therapy in the dissolution of thrombosis are discussed.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The case of a 65 year old woman referred for further evaluation of back pain and with abnormalities at ultrasound including increase in portal vein diameter and splenomegaly is presented.
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Key Findings & Data:An abnormal increase of cells in circulating blood may lead to portal vein thrombosis in patients with myeloproliferative disorders such as chronic myleoid leukemia.
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Conclusion & Impact:In this report, etiopathogenetic factors of portal vein thrombosis and the role of cytoreductive therapy in the dissolution of thrombosis are discussed.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Hidroksiüre · Lökofarez · Venöz tromboz

Abstract

The case of a 65 year old woman referred for further evaluation of back pain and with abnormalities at ultrasound including increase in portal vein diameter and splenomegaly is presented. Other tests, including bone marrow biopsy and Doppler ultrasound, led to a diagnosis of portal vein thrombosis secondary to chronic myleoid leukemia. After prompt cytoreductive threrapy with leukapheresis and hydroxyurea, resolution of portal vein thrombosis and portal hypertension was achieved within a in one-month period. An abnormal increase of cells in circulating blood may lead to portal vein thrombosis in patients with myeloproliferative disorders such as chronic myleoid leukemia. Chronic myleoid leukemia is an unusual cause of portal vein thrombosis and portal hypertension. Early administration of cytoreductive therapy may lead to the resolution of portal vein thrombosis. In this report, etiopathogenetic factors of portal vein thrombosis and the role of cytoreductive therapy in the dissolution of thrombosis are discussed.

Özet

Bu takdim edilen vaka raporunda, 65-yaşındaki bir bayan yan ağrısının değerlendirilmesi için doktora müracat eder. Ultrason tetkikinde splenomegali ve portal ven çapında artma gibi anormallikler görülünce daha ileri değerlendirme için gastroenteroloji kliniğine gönderilir. Doppler ultrason ve diğer tetkiklerle hastanın kronik myeloid lösemiye sekunder gelişen portal ven trombozu olduğu anlaşılır. Lökoferez ve hidroksiüre ile yapılan hızlı tedaviyi takiben bir aylık period içinde portal hipertansiyon ve portal ven trombozunun kaybolduğu gözlenmiştir. Kronik myeloid lösemi gibi myeloproliferatif hastalığı olan hastalarda dolaşan kanda anormal sayıda artmış hücreler portal ven trombozuna neden olabilirler. Kronik myleoid lösemi, portal hipertansiyon ve portal ven trombozunun nadir bir sebebidir. Erkenden sitoredüktif tedavinin uygulanması portal ven trombozunun erimesiyle sonuçlanabilir. Bu vaka sunumu dolayısıyla, portal ven trombozunun etyopatogenetik faktörleri ve trombozun erimesindeki sitoredüktif tedavinin rolüde ayrıca tartışılmıştır.

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Cite This Article

İNCE, A. T., BÖLÜKBAŞ, C., DALAY, R., SÖKMEN, H. M., KURDAŞ, O. Ö., SÜLEYMANLAR, İ., IŞITAN, F. (2003). Kronik myeloid lösemili bir hastada sitoredüktif tedaviden sonra portal ven trombozu ve nonsirotik portal hipertansiyonun hızla kaybolması. Turkish Journal of Gastroenterology, Cilt: 14 - Sayı: 2, 141–144. https://ajindex.com/articles/410397

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