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Journals / Turkish Journal of Gastroenterology / 2019 / Cilt: 30 - Sayı: 10

Investigation of JAM-A (rs790056) and LFA-1 (rs8058823) gene variants in Turkish colorectal cancer patients

Burcu ÇAYKARA
Hani ALSAADONI
Halime Hanım PENÇE
Sadrettin PENÇE
Hülya YILMAZ AYDOĞAN
Didem TAŞTEKİN
Pages
872–876
DOI
—
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⚡ TL;DR(Too Long; Didn't Read)

Haplotype analysis showed that GC haplotype(LFA-1 rs8058823G and JAM-A rs790056C) frequency was significantly higher in the patient group (p=0.041) than in controls.Conclusion: JAM-A rs790056 variation may be effective in the development of colorectal cancer.

📌 3 Key Takeaways

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Objective & Hypothesis:Background/Aims: Lymphocyte function-associated antigen 1 (LFA-1) is a transmembrane glycoprotein expressed on the surface ofleukocytes and containing the binding domain for junctional adhesion molecule-A (JAM-A).
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Key Findings & Data:The aim of the present study was to evaluatethe effects of JAM-A and LFA-1 variants on the formation of colorectal cancer and metastasis.Materials and Methods: A total of 82 subjects with colorectal cancer and 67 healthy subjects were studied.
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Conclusion & Impact:Haplotype analysis showed that GC haplotype(LFA-1 rs8058823G and JAM-A rs790056C) frequency was significantly higher in the patient group (p=0.041) than in controls.Conclusion: JAM-A rs790056 variation may be effective in the development of colorectal cancer.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Background/Aims: Lymphocyte function-associated antigen 1 (LFA-1) is a transmembrane glycoprotein expressed on the surface ofleukocytes and containing the binding domain for junctional adhesion molecule-A (JAM-A). The aim of the present study was to evaluatethe effects of JAM-A and LFA-1 variants on the formation of colorectal cancer and metastasis.Materials and Methods: A total of 82 subjects with colorectal cancer and 67 healthy subjects were studied. DNA was isolated from bloodsamples, and variations were determined using the polymerase chain reaction and restriction fragment length polymorphism method.Results: JAM-A rs790056 CC genotype and C allele were found to be higher in the colorectal cancer group (p<0.05), and approximately3-fold increased colorectal cancer risk with CC genotype was determined (p=0.029). Haplotype analysis showed that GC haplotype(LFA-1 rs8058823G and JAM-A rs790056C) frequency was significantly higher in the patient group (p=0.041) than in controls.Conclusion: JAM-A rs790056 variation may be effective in the development of colorectal cancer.

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Cite This Article

ÇAYKARA, B., ALSAADONI, H., PENÇE, H. H., PENÇE, S., AYDOĞAN, H. Y., TAŞTEKİN, D. (2019). Investigation of JAM-A (rs790056) and LFA-1 (rs8058823) gene variants in Turkish colorectal cancer patients. Turkish Journal of Gastroenterology, Cilt: 30 - Sayı: 10, 872–876. https://ajindex.com/articles/408782

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