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Journals / Turkish Neurosurgery / 2014 / Cilt: 24 - Sayı: 3

Anevrizmal Subaraknoid Kanama Tedavisi Sonrası Beyin Omurilik Sıvısı Sistatin C Düzeyleri

Cerebrospinal Fluid Cystatin C levels Following treatment for Aneurysmal Subarachnoid Hemorrhage

Ethem GÖKSU
Ebru GOKSU
BİLGE KARSLI
Mahmut AKYÜZ
Halide AKBAŞ
ALİ ÜNAL
Neval BOZTUĞ
Recai TUNCER
Pages
391–397
DOI
—
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CONCLUSION: The raised CSF CC concentrations appear to be associated with the severity of bleeding, intraoperative ischemic events and poor prognostic outcome in patients with aneurysmal SAH.

📌 3 Key Takeaways

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Objective & Hypothesis:AIM: To investigate the changes of cerebrospinal fluid (CSF) cystatin C (CC) levels associated with the postoperative ischemic conditions and prognostic outcome in patients with aneurysmal subarachnoid hemorrhage (SAH).
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Key Findings & Data:MATERIAL and METHODS: The study group consisted of 40 patients with microsurgically clipped intracranial aneurysms (IA s) and 22 control CSF samples.
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Conclusion & Impact:CONCLUSION: The raised CSF CC concentrations appear to be associated with the severity of bleeding, intraoperative ischemic events and poor prognostic outcome in patients with aneurysmal SAH.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

AIM: To investigate the changes of cerebrospinal fluid (CSF) cystatin C (CC) levels associated with the postoperative ischemic conditions and prognostic outcome in patients with aneurysmal subarachnoid hemorrhage (SAH). MATERIAL and METHODS: The study group consisted of 40 patients with microsurgically clipped intracranial aneurysms (IA s) and 22 control CSF samples. In patients, CSF samples were taken from the lumbar intrathecal catheter for CC measurement, at the beginning of operation, immediately after the operation (early postoperative), and the first postoperative day (late postoperative). RESULTS: CC levels in three periods were significantly higher in patients with Hunt-Hess scores of 4, 5 than 1, 2, 3. There was a significant difference between the CC concentrations on the first postoperative day and controls. In patients who developed focal cerebral ischemia, CC levels at early and late postoperative periods were significantly higher than the group without ischemia. In addition, patients with poor prognostic outcome (GOS score of 1, 2, 3) had significantly higher levels of CC in all three periods than that of patients with good outcome (GOS score of 4, 5). CONCLUSION: The raised CSF CC concentrations appear to be associated with the severity of bleeding, intraoperative ischemic events and poor prognostic outcome in patients with aneurysmal SAH.

Özet

AMAÇ: Anevrizmal subaraknoid kanamalı hastalarda (SAK), postoperatif iskemik durumlar ve prognozla ilişkili olarak beyin omurilik sıvısı (BOS) sistatin C (SC) düzeylerindeki değişiklikleri araştırmaktır. YÖNTEM ve GEREÇLER: Çalışma grubu, mikrocerrahi olarak klibe edilmiş intrakranial anevrizmalı (İA) 40 hasta ile 22 kontrol BOS örneğini içermekteydi. Hastalarda BOS örnekleri lomber intratekal katater yoluyla ameliyatın başında, hemen sonrasında (erken postoperatif) ve ameliyat sonrası birinci günde (geç postoperatif) sağlandı. BuLGuLAR: Üç dönemdeki CC düzeyleri de Hunt-Hess skoru 4, 5 hastalarda, 1, 2 ve 3 olanlara göre anlamlı olarak yüksekti. Postoperatif birinci gün SC düzeyleri ile kontrol grubu arasındaki fark istatistiksel olarak anlamlı idi. Fokal serebral iskemi gelişen hastalarda erken ve geç postoperatif dönemdeki SC düzeyleri, iskemi gelişmeyen gruba göre anlamlı olarak yüksekti. Ayrıca, kötü prognoz gösteren (GOS 1, 2, 3) hastalar, iyi prognoz gösterenlere göre (GOS 4, 5) her üç dönemde de anlamlı olarak yüksek SC konsantrasyonlarına sahipti. SONUÇ: Anevrizmal SAKlı hastalarda artmış BOS SC düzeyleri, kanamanın ciddiyeti, intraoperatif iskemik olaylar ve kötü prognozla ilişkili görünmektedir.

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Cite This Article

GÖKSU, E., GOKSU, E., KARSLI, B., AKYÜZ, M., AKBAŞ, H., ÜNAL, A., BOZTUĞ, N., TUNCER, R. (2014). Anevrizmal Subaraknoid Kanama Tedavisi Sonrası Beyin Omurilik Sıvısı Sistatin C Düzeyleri. Turkish Neurosurgery, Cilt: 24 - Sayı: 3, 391–397. https://ajindex.com/articles/405459

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