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Journals / Turkish Journal of Pharmaceutical Sciences / 2010 / Cilt: 7 - Sayı: 2

Bazı sarkoidoz vakalarında mikobakteriyel DNA’nın moleküler analizi: Klinik yönü ile ilişkisi ve 10 yıllık gözlem

Molecular analysis of mycobacterial DNA in some cases of sarcoidosis: Correlation with clinical course and 10 years’ observation

Kurtuluş Melahat ÜLKÜER
Özdemir Özlem KUMBASAR
Gökhan ÇELİK
Pages
189–195
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We discussed tuberculin test results and clinical course of M. tuberculosis positive and negative patients with polymerase chain reaction. we cannot make a conclusion about a relationship between clinical course and mycobacterial DNA positivity.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:We present six patients with sarcoidosis whose transbronchial biopsy specimens had been investigated, the gene of immunogenic protein MPB64 for Mycobacterium tuberculosis by polymerase chain reaction analysis.
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Key Findings & Data:M. tuberculosis DNA was detected in three of them by PCR.
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Conclusion & Impact:We discussed tuberculin test results and clinical course of M. tuberculosis positive and negative patients with polymerase chain reaction. we cannot make a conclusion about a relationship between clinical course and mycobacterial DNA positivity.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

We present six patients with sarcoidosis whose transbronchial biopsy specimens had been investigated, the gene of immunogenic protein MPB64 for Mycobacterium tuberculosis by polymerase chain reaction analysis. M. tuberculosis DNA was detected in three of them by PCR. We followed patients with sarcoidosis for ten years. We discussed tuberculin test results and clinical course of M. tuberculosis positive and negative patients with polymerase chain reaction. we cannot make a conclusion about a relationship between clinical course and mycobacterial DNA positivity.

Özet

Transbronşial biopsi örneklerinde M. tuberculosis, immunojenikprotein MPB64 geni polimeraz zincir reaksiyonuyla araştırılan altı hasta sunuldu. PCR'la altı örneğin üçünde M. tuberculosis DNA 'sı belirlendi. Sarkoidozlu hastalar on yıl izlendi. Polimeraz zincir reaksiyonuyla M. tuberculosis pozitif ve negatif hastaların tüberkülin test sonuçları ve klinik yönü tartışıldı. Klinik yönü ve mikobakteriyel DNA pozitifliği arasında ilişki olmadığına karar verildi.

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Cite This Article

ÜLKÜER, K. M., KUMBASAR, Ö. Ö., ÇELİK, G. (2010). Bazı sarkoidoz vakalarında mikobakteriyel DNA’nın moleküler analizi: Klinik yönü ile ilişkisi ve 10 yıllık gözlem. Turkish Journal of Pharmaceutical Sciences, Cilt: 7 - Sayı: 2, 189–195. https://ajindex.com/articles/404099

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