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Journals / Turkish Journal of Pharmaceutical Sciences / 2014 / Cilt: 11 - Sayı: 3

Eryngium campestre Ekstrelerinin Glutatyon-S-Transferaz, Glutatyon Peroksidaz ve Katalaz Enzim Aktiviteleri Üzerine Etkileri

The Effects of Eryngium campestre Extracts on Glutathione-S-Transferase, Glutathione Peroxidase and Catalase Enzyme Activities

Merve G. GÜNEŞ
Belgin S. İŞGÖR
Yasemin G. İŞGÖR
Naznoosh SHOMALI MOGHADDAM
Fatmagül GEVEN
ÖZLEM YILDIRIM
Pages
339–346
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this study, none of the extracts evaluated were shown any reasonable GPx and CAT inhibition

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Eryngium campestre L. (Apiaceae) are known in Turkish folk medicine as ‘Bogadikeni’ and wildly distributed in all parts of Turkey.
📊
Key Findings & Data:The evaluation of extracts against biological target revealed that, the maximum GST enzymes inhibition activities was observed with methanol extract from flowers of E. campestre with IC50 value of 363 ng/mL.
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Conclusion & Impact:In this study, none of the extracts evaluated were shown any reasonable GPx and CAT inhibition
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Eryngium campestre L. (Apiaceae) are known in Turkish folk medicine as ‘Bogadikeni’ and wildly distributed in all parts of Turkey. Infusion of different parts of this species are well known as diuretic, appetizer and stimulant. In the present study, methanol extracts from flowers and leaves of E. campestre were evaluated for their potential medicinal value in terms of biological targets participate in antioxidant defense such as glutathione-S-transferase (GST), glutathione peroxidase (GPx) and catalase (CAT). Results obtained show that the methanol extract of flowers were found to have higher amount of phenolic and flavonoid contents than the leaves. The evaluation of extracts against biological target revealed that, the maximum GST enzymes inhibition activities was observed with methanol extract from flowers of E. campestre with IC50 value of 363 ng/mL. In this study, none of the extracts evaluated were shown any reasonable GPx and CAT inhibition

Özet

Geleneksel Türk tıbbında 'Boğa dikeni' olarak bilinen Eryngium campestre L. (Apiaceae), Türkiye'nin her bölgesinde genişçe yayılım göstermektedir. Bu bitkinin çeşitli kısımlarından hazırlanan infüzyonların, diüretik, iştah açıçı ve uyarıcı olarak etki gösterdiği bilinmektedir. Bu çalışmada, E. campestre'nin çiçek ve yapraklarından elde edilen metanol özütlerinin, antioksidan savunma sistemlerinde yer alan glutatyon- S-transferaz (GST), glutatyon peroksidaz (GPx) ve katalaz (CAT) enzimleri üzerine etkileri incelenmiştir. Elde edilen sonuçlarda, bitkinin çiçek kısımlarının metanol özütlerinin fenolik ve flavonoid içeriklerinin, yapraklarından elde edilen özütlerden daha yüksek değere sahip olduğu bulunmuştur. Biyolojik hedeflere karşı özütlerin etkilerinin değerlendirilmesinde ise, maksimum GST inhibisyonunun, E. campestre'nin çiçek kısmından elde edilen ekstrelerle sağlandığı ve IC50 değerinin 363 ng/mL olduğu görülmüştür. Bu çalışmada değerlendirilen özütlerin GPx ve CAT inhibisyonu sağlamadığı görülmüştür

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Cite This Article

GÜNEŞ, M. G., İŞGÖR, B. S., İŞGÖR, Y. G., MOGHADDAM, N. S., GEVEN, F., YILDIRIM, Ö. (2014). Eryngium campestre Ekstrelerinin Glutatyon-S-Transferaz, Glutatyon Peroksidaz ve Katalaz Enzim Aktiviteleri Üzerine Etkileri. Turkish Journal of Pharmaceutical Sciences, Cilt: 11 - Sayı: 3, 339–346. https://ajindex.com/articles/404008

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