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Journals / Turkish Journal of Pharmaceutical Sciences / 2015 / Cilt: 12 - Sayı: 1

Synthesis and Antimicrobial Activity of Benzimidazole-Based Acetamide Derivatives

MEHLİKA DİLEK ALTINTOP
Pages
29–38
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Compounds 2s and 2u also exhibited the highest inhibitory activity against Fusarium solani with a MIC value of 125 μg/mL, whereas ketoconazole showed its antifungal activity with a MIC value of 62.5 μg/mL.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In the current work, new benzimidazole-based acetamide derivatives (2a-u) were synthesized and screened for their in vitro antimicrobial activity.
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Key Findings & Data:Among these derivatives, compounds 2b-2g were found to be the most promising antibacterial agents against Pseudomonas aeruginosa.
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Conclusion & Impact:Compounds 2s and 2u also exhibited the highest inhibitory activity against Fusarium solani with a MIC value of 125 μg/mL, whereas ketoconazole showed its antifungal activity with a MIC value of 62.5 μg/mL.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In the current work, new benzimidazole-based acetamide derivatives (2a-u) were synthesized and screened for their in vitro antimicrobial activity. Among these derivatives, compounds 2b-2g were found to be the most promising antibacterial agents against Pseudomonas aeruginosa. These compounds and streptomycin exhibited the same level of antibacterial activity with a MIC value of 125 μg/mL. Compounds 2p, 2s, 2t and 2u were the most potent antifungal derivatives against Candida krusei with a MIC value of 125 μg/mL when compared with ketoconazole (MIC= 62.5 μg/mL). Compounds 2s and 2u also exhibited the highest inhibitory activity against Fusarium solani with a MIC value of 125 μg/mL, whereas ketoconazole showed its antifungal activity with a MIC value of 62.5 μg/mL.

Özet

Bu çalışmada, yeni benzimidazol taşıyan asetamit türevleri (2a-u) sentezlendi ve in vitro antimikrobiyal etkileri için tarandı. Bu türevler arasında, 2b-2g bileşikleri Pseudomonas aeruginosa'ya karşı en ümit verici antibakteriyel maddeler olarak bulundu. Bu bileşikler ve streptomisin 125 μg/mL'lik bir MIC değeri ile aynı düzeyde antibakteriyel etki gösterdiler. Ketokonazol (MIC = 62.5 μg/mL) ile karşılaştırıldığında, 2p, 2s, 2t ve 2u bileşikleri 125 μg/mL'lik bir MIC değeri ile Candida kruseiye karşı en etkili antifungal türevlerdi. 2s ve 2u bileşikleri 125 μg/mL'lik bir MIC değeri ile Fusarium solaniye karşı da en yüksek inhibe edici aktiviteyi gösterirken, ketokonazol antifungal etkisini 62.5 μg/mL'lik bir MIC değeri ile gösterdi.

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Cite This Article

ALTINTOP, M. D. (2015). Synthesis and Antimicrobial Activity of Benzimidazole-Based Acetamide Derivatives. Turkish Journal of Pharmaceutical Sciences, Cilt: 12 - Sayı: 1, 29–38. https://ajindex.com/articles/403986

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