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Journals / Turkish Journal of Pharmaceutical Sciences / 2004 / Cilt: 1 - Sayı: 3

Naproksen'in tabletlerde birinci türev potansiyometri ile miktar tayini

Determination of naproxen in tablets by using first derivative potentiometry

ÜLKÜ DİLEK UYSAL
Muzaffer TUNÇEL
Pages
217–223
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It was found to be 0.70 for RSD % and 0.3 for ±CL (p=0.05).

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this article the potentiometric determination of naproxen sodium is described.
📊
Key Findings & Data:A solvent system consisting of aqueous solution of 20% ethanol (v/v) at an ionic strength of 0.1 adding sodium chloride was found to be suitable for the determination of naproxen.
💡
Conclusion & Impact:It was found to be 0.70 for RSD % and 0.3 for ±CL (p=0.05).
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Potensiyometri · Tabletler · Naproksen

Abstract

In this article the potentiometric determination of naproxen sodium is described. A solvent system consisting of aqueous solution of 20% ethanol (v/v) at an ionic strength of 0.1 adding sodium chloride was found to be suitable for the determination of naproxen. Same solvent system was employed for titrant of 0.1 N HCl and to titrate the active material. Validation processes as repeatability (precision) (n=6) were computed. It was found to be 0.70 for RSD % and 0.3 for ±CL (p=0.05). The analysis of 275 and 550 mg naproxen sodium tablets were carried out in the filtered and unfiltered tablet solutions for three consecutive days considering intra and inter-days. Precision values were in the range of 0.16-0.33 for unfiltered and 0.10-0.29 for filtered solutions and the amount of the tablets was found to be in the range of (103.0-108.7%) for unfiltered and (102.9-107.7%) for filtered solutions. The method proposed here is precise simple and rather cheap. Therefore, it is suggested for the routine analysis of naproxen sodium tablets.

Özet

Bu çalışmada, naproksen sodyumun potansiyometrik tayini tanıtılmaktadır. Naproksenin tayini için en iyi çözücü sistemi, sodyum klorür ilavesiyle 0,1 iyonik şiddete ayarlı % 20 etanol (h/h) olarak bulundu. Aktif maddenin titrasyonunda ve 0,1 N HCl için de benzer çözücü sistemi kullanıldı. Validasyon işlemleri tekrarlanabilirlik (kesinlik) (n-6) olarak hesaplandı. % RSD için 0,70 ve CL (p=0,05) için 0,3 olarak hesaplandı. Naproksen sodyumun 275 ve 550 mg'lık tabletlerinin analizi, tablet çözeltilerinin süzülerek ve süzülmeden ardışık üç gün, güniçi ve günlerarası bakımından yapıldı. Kesinlik değerleri, süzülmemiş tablet çözeltileri için 0,16-0,33, süzülmüş tablet çözeltileri için 0,10-0,29 ve tabletlerin miktarı süzülmemişler için (%103,0-108,7), süzülmüşler için (%102,9-107,7) olarak bulundu. Önerilen bu metot tekrarlanabilir, basit ve oldukça ucuzdur. Bu nedenlerle, bu yöntem naproksen sodyum tabletlerinin rutin analizleri için önerilmektedir.

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Cite This Article

UYSAL, Ü. D., TUNÇEL, M. (2004). Naproksen'in tabletlerde birinci türev potansiyometri ile miktar tayini. Turkish Journal of Pharmaceutical Sciences, Cilt: 1 - Sayı: 3, 217–223. https://ajindex.com/articles/403899

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