Journals / Turkish Journal of Pharmaceutical Sciences / 2008 / Cilt: 5 - Sayı: 2

Şeker yerine kullanılan polidekstroz ve oligofruktoz içeren karışım tatlandırıcının prebiyotik etkilerinin değerlendirilmesi

The prebiotic effects of mixed sweetener containing polydextrose and oligofructose substituted sugar in diet

Pages
95–106
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As a result, 12g/d consumption of MS generated prebiotic effects in colon of healthy volunteers.

📌 3 Key Takeaways

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Objective & Hypothesis:Prebiotics are non-digestable food ingredients, made of carbohydrates targeting human colonic microflora.
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Key Findings & Data:MS included PD (40.9 %) and OF (20%).
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Conclusion & Impact:As a result, 12g/d consumption of MS generated prebiotic effects in colon of healthy volunteers.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Prebiotics are non-digestable food ingredients, made of carbohydrates targeting human colonic microflora. In the present study, the prebiotic potential of oligofructose (OF) and polydextrose (PD) in mixed sweetener (MS) in cake was investigated in healthy male volunteers. MS included PD (40.9 %) and OF (20%). Aim of this study was to investigate the tolerable amount of MS and to evaluate the prebiotic effects of MS ingestion. This study was conducted in two steps. In the first step of the study, gastro­ intestinal system symptoms of the volunteers were examined during four weeks and the tolerable amount of MS was detected. In the second step the prebiotic effects of tolerable dosage of MS (12 g/d) ingestion was investigated. At the end of the placebo and test period, faecal samples were analysed. Flatus was more frequent and intense in volunteers consuming MS48 than the other groups and MS ingestion affected fecal weight in all groups. MS ingestion increased the amount of Bifidobacteria, Lactobacillus and total anaerobes (except for Clostridium) and decreased all aerobes. However these changes were not statistically significant (p>0.05). MS consumption decreased the amount of all aerobes, but only the reduction in the number of Staphylococcus was statistically significant compared to placebo period (p<0.01). As a result, 12g/d consumption of MS generated prebiotic effects in colon of healthy volunteers.

Özet

Prebiyotikler, insanlarda bagirsak florasim hedefleyen ve sindirilemeyen karbonhidrat yapısındaki besin bileşenleridir. Bu çalismada, oligofruktoz (OF) ve polidekstroz (PD) ’dan hazırlanmis karisim tatlandincının (KT), bagirsak florası üzerindeki prebiyotik etkileri incelenmiştir. KT, % 40.9 oranmda PD ve %20 oranmda OF iqermektedir. Çalismaya gönüllu ve sağlıklı erkek bireyler alınmistır. Çalisma iki aşamada yürütülmustür. Birinci aşamada, gönüllulerin dört hafta süreyle gastro-intestinal sistem şikdyetleri değerlendirilerek tolerans dozu belirlenmiştir. İkinci aşamada, KT’nın en iyi tolere edilebilen dozu (12 g/gün) ’nun prebiyotik etkileri belirlenmiştir. Plasebo ve test periyodlarimn sonunda diskı örneklerinde bakteriyel analizler yapılmistır. Gaz şikayeti olanların sayısı ve şiddeti, KT48 grubunda, diğer gruplardan daha fazla olmuş ve karisim tatlandina tüketimi turn doz gruplarında diskı agirligini etkilemiştir. KT tüketimiyle diskıda görülen Bifidobacteria, Lactobacillus, Bacteroides ve total anaerob bakterilerin sayılan artarken, Clostridium sayısı azalmis, fakat bu azalma istatistiksel açıdan önemli bulunmamistır (p>0.05). Aerob bakterilerin turnu KT tüketimiyle azalmistır. Sadece Staphylococcus sayısında görülen azalma, istatistiksel olarak önemli bulunmuştur (p<0.01). Sonuç olarak, 12 g/gün KT tüketimi sağlıklı gönüllulerde kolonda prebiyotik etkiler göstermiştir.

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Cite This Article

DEMİRCİOĞLU, Y., BAŞOĞLU, S., ÖZKAN, S., ŞİMŞEK, I., ABBASOĞLU, U. (2008). Şeker yerine kullanılan polidekstroz ve oligofruktoz içeren karışım tatlandırıcının prebiyotik etkilerinin değerlendirilmesi. Turkish Journal of Pharmaceutical Sciences, Cilt: 5 - Sayı: 2, 95–106. https://ajindex.com/articles/403846

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