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Journals / Türk Biyokimya Dergisi / 2021 / Cilt: 46 - Sayı: 2

Evaluation of serum 25-hydroxyvitamin D levels and cortisol/dehydroepiandrosterone sulfate ratio in chronic spontaneous urticaria

Eren VURGUN
Bachar MEMET
Emek KOCATÜRK
Gülcan GÜNTAŞ
Pages
191–196
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Conclusions: Lower 25(OH)D levels and higher cortisol/ DHEA-S ratio in CSU patients who have higher stress level indicate that the level of 25(OH)D seems to be associated with steroidogenesis and thus 25(OH)D levels may decrease secondarily in CSU.

📌 3 Key Takeaways

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Objective & Hypothesis:Background: Various studies have reported different re sults for cortisol, dehydroepiandrosterone sulfate (DHEA-S) and 25-hydroxyvitamin D (25(OH)D) levels in patients with chronic spontaneous urticaria (CSU) and these were not sufficient for explaining the underlying reasons.
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Key Findings & Data:Objectives: To evaluate the levels of cortisol, DHEA-S and 25(OH)D in patients with CSU and to investigate the relationships between these parameters.
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Conclusion & Impact:Conclusions: Lower 25(OH)D levels and higher cortisol/ DHEA-S ratio in CSU patients who have higher stress level indicate that the level of 25(OH)D seems to be associated with steroidogenesis and thus 25(OH)D levels may decrease secondarily in CSU.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Background: Various studies have reported different re sults for cortisol, dehydroepiandrosterone sulfate (DHEA-S) and 25-hydroxyvitamin D (25(OH)D) levels in patients with chronic spontaneous urticaria (CSU) and these were not sufficient for explaining the underlying reasons. Objectives: To evaluate the levels of cortisol, DHEA-S and 25(OH)D in patients with CSU and to investigate the relationships between these parameters. Methods: Fifty patients who had diagnosed with CSU and 30 healthy controls were enrolled into the study. Stress levels of CSU and control groups were determined by perceived stress scale (PSS-14). The activity of urticaria of the patients was also determined by urticaria activity score (UAS7). Serum DHEA-S, cortisol and 25(OH)D levels of the participants were measured and compared. Results: DHEA-S and 25(OH)D levels of CSU patients were lower than the control group (p<0.001 and p<0.001, respectively) while stress level and cortisol/DHEA-S ratio were higher (p<0.001 and p=0.003, respectively). Conclusions: Lower 25(OH)D levels and higher cortisol/ DHEA-S ratio in CSU patients who have higher stress level indicate that the level of 25(OH)D seems to be associated with steroidogenesis and thus 25(OH)D levels may decrease secondarily in CSU.

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Cite This Article

VURGUN, E., MEMET, B., KOCATÜRK, E., GÜNTAŞ, G. (2021). Evaluation of serum 25-hydroxyvitamin D levels and cortisol/dehydroepiandrosterone sulfate ratio in chronic spontaneous urticaria. Türk Biyokimya Dergisi, Cilt: 46 - Sayı: 2, 191–196. https://ajindex.com/articles/399047

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