SavedAdd your journal

Journals / BEYOGLU EYE JOURNAL / 2021 / Cilt: 6 - Sayı: 2

Conjunctival Impression Cytology and Tear Function in Patients with Keratoconus

Deniz ÖZARSLAN ÖZCAN
Sait Coşkun ÖZCAN
Didar GÜRSOY
Pages
79–83
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The grade of keratoconus appears to be associated with conjunctival cytologic changes.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: The aim of this study was to evaluate the ocular surface alterations of conjunctival cytological changes and tear function in patients with keratoconus.
📊
Key Findings & Data:Methods: A total of 98 eyes with keratoconus and 68 eyes of age- and sex- matched healthy subjects were included in this prospective study.
💡
Conclusion & Impact:The grade of keratoconus appears to be associated with conjunctival cytologic changes.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Objectives: The aim of this study was to evaluate the ocular surface alterations of conjunctival cytological changes and tear function in patients with keratoconus. Methods: A total of 98 eyes with keratoconus and 68 eyes of age- and sex- matched healthy subjects were included in this prospective study. Ophthalmological evaluations, including Ocular Surface Disease Index (OSDI), tear break-up time (TBUT), ocular surface staining (OSS), Schirmer test, and conjunctival impression cytology (CIC), were performed. Results: The mean participant age was 23.4±5.3 years in the keratoconus group and 24.9±6.0 years in the control group. In the keratoconus group, the mean OSDI and OSS scores were statistically significantly higher than those of the controls, and the Schirmer and TBUT results were statistically significantly lower (all p<0.001). The severity of keratoconus was positively correlated with the CIC grade (r=0.292; p=0.004). Conclusion: Keratoconus results in deterioration of the ocular surface, including CIC and tear function parameters. The grade of keratoconus appears to be associated with conjunctival cytologic changes.

🔖

Cite This Article

ÖZCAN, D. Ö., ÖZCAN, S. C., GÜRSOY, D. (2021). Conjunctival Impression Cytology and Tear Function in Patients with Keratoconus. BEYOGLU EYE JOURNAL, Cilt: 6 - Sayı: 2, 79–83. https://ajindex.com/articles/396508

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (17)

  1. Godefrooji DA, de Wit GA, Uiterwaal CS, Imhof SM, Wisse RPL. Age specific incidence and prevalence of keratoconus: a nationwide registration study. Am J Ophthalmol 2017;175:169– 72
  2. Sharma N, Rao K, Maharana PK, Vajpayee RB. Ocular allergy and keratoconus. Indian J Ophthalmol 2013;61:407–9
  3. Dogru M, Karakaya H, Ozçetin H, Ertürk H, Yücel A, Ozmen A, et al. Tear function and ocular surface changes in keratoconus. Ophthalmology 2003;110:1110–8
  4. Thatcher RW, Darougar S, Jones BR. Conjunctival impression cytology. Arch Ophthalmol 1977;95:678–81
  5. Hagan S. Biomarkers of ocular surface disease using impression cytology. Biomark Med 2017;11:1135–47
  6. Krumeich JH, Kezirian GM. Circular keratotomy to reduce astigmatism and improve vision in stage I and II keratoconus. J Refract Surg 2009;25:357–65
  7. Schiffman RM, Christianson MD, Jacobsen G, Hirsch JD, Reis BL. Reliability and validity of the ocular surface disease index. Arch Ophthalmol 2000;118:615–21
  8. Whitcher JP, Shiboski CH, Shiboski SC, Heidenreich AM, Kitagawa K, Zhang S, et al. A simplified quantitative method for assessing keratoconjunctivitis sicca from the Sjögren’s Syndrome International Registry. Am J Ophthalmol 2010;49:405–15
  9. Wolffsohn JS, Arita R, Chalmers R, Djalilian A, Dogru M, Dumbleton K, et al. TFOS DEWS II Diagnostic Methodology report. Ocul Surf 2017;15:539–74
  10. Nelson JD. Impression cytology. Cornea 1988;7:71–81
  11. Doughty MJ. Goblet cells of the normal human bulbar conjunctiva and their assessment by impression cytology sampling. Ocul Surf 2012;10:149–69
  12. Kenney MC, Brown DJ, Rajeev B. Everett Kinsey lecture. The elusive causes of keratoconus: a working hypothesis. CLAO J 2000;26:10–3
  13. Reinstein DZ, Gobbe M, Archer TJ, Silverman RH, Coleman DJ. Epithelial, stromal, and total corneal thickness in keratoconus: three-dimensional display with artemis very-high frequency digital ultrasound. J Refract Surg 2010;26:259–71
  14. Lema I, Duran JA. Inflammatory molecules in the tears of patients with keratoconus. Ophthalmology 2005;112:654–9
  15. Lema I, Sobrino T, Duran JA, Brea D, Diez-Feijoo E. Subclinical keratoconus and inflammatory molecules from tears. Br J Ophthalmol 2009;93:820–4
  16. Lema I, Duran JA, Ruiz C, Diez-Feijoo E, Acera A, Merayo J. Inflammatory response to contact lenses in patients with keratoconus compared with myopic subjects. Cornea 2008;27:758– 63
  17. Balasubramanian SA, Pye DC, Wilcox MD. Effects of eye rubbbing on the levels of proteas