Effect of sildenafil citrate on the liver structure and function in obstructive jaundice: An experimental study

Significant differenceswere observed among the groups with regard to cholestasis, fibrosis, inflammation, and necrosis (p 0.05).Conclusion: Oral administration of 10 mg/kg sildenafil citrate dramatically reverses the biochemical and histopathologicalliver changes induced by obstructive jaundice in rats.

📌 3 Key Takeaways

🎯

Objective & Hypothesis:Objective: We aimed to investigate the effect of 10 mg/kg sildenafil on the structure and function of the liver in arat model of obstructive jaundice.Material and Methods: Sixty-two male Wistar albino rats were distributed into six different groups.

📊

Key Findings & Data:Obstructive jaundicewas performed by legating the common bile duct. 10 mg/kg sildenafil citrate in drinking water was deliveredorally after the operation before sacrificing them.

💡

Conclusion & Impact:Significant differenceswere observed among the groups with regard to cholestasis, fibrosis, inflammation, and necrosis (p 0.05).Conclusion: Oral administration of 10 mg/kg sildenafil citrate dramatically reverses the biochemical and histopathologicalliver changes induced by obstructive jaundice in rats.

🔬Design:Modeling & Simulation

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Özet

Objective: We aimed to investigate the effect of 10 mg/kg sildenafil on the structure and function of the liver in arat model of obstructive jaundice.Material and Methods: Sixty-two male Wistar albino rats were distributed into six different groups. Obstructive jaundicewas performed by legating the common bile duct. 10 mg/kg sildenafil citrate in drinking water was deliveredorally after the operation before sacrificing them. Rats were sacrificed either after 10 or 28 days according to thestudy design. The blood and tissue samples from the liver were obtained to perform a biochemical and histopathologicalanalysis to study functional and structural changes in the liver.Results: At the 10th day, there was no difference between the sildenafil-treated and control groups with regard tothe aspartate aminotransferase and alanine aminotransferase levels (p=0.423, p=0.661). The alkaline phosphatasetotal bilirubin levels among the groups were statistically different (p 0.05). Significant differenceswere observed among the groups with regard to cholestasis, fibrosis, inflammation, and necrosis (p 0.05).Conclusion: Oral administration of 10 mg/kg sildenafil citrate dramatically reverses the biochemical and histopathologicalliver changes induced by obstructive jaundice in rats.

🔖

Cite This Article

ŞİMŞEK, T., ERSOY, Ö. F., ÖZSOY, Z., YENİDOĞAN, E., KAYAOĞLU, H. A., ÖZKAN, N., ŞAHİN, M. (2018). Effect of sildenafil citrate on the liver structure and function in obstructive jaundice: An experimental study. Turkish Journal of Surgery, Cilt: 34 - Sayı: 2, 111–116. https://ajindex.com/articles/390555

📄 Full Text PDF Viewer

Open in New Tab ↗

↗New Tab

📄

PDF görüntüleyici hazırlanıyor...

References (7)

Gümüs M, Tekin R, Firat U, Onder A, Kapan M, Böyük A, et al. The effects of pomegranate on bacterial translocation in rats with obstructive jaundice. Eur Rev Med Pharmacol Sci 2013; 17: 1488- 1494. James S Doley. Extrahepatic biliary obstruction. Systemic effects, diagnosis,management. In: Bircher J, Benhamou J-P (Eds). Oxford Textbook of Clinical Hepatology (2th ed) Oxford: 1999; pp 1581- 1590. Mersin HH, Akbaba M, Başkan E, Berberoğlu U. N-acetylcysteine can attenuate liver injury in obstructive jaundice in rats. Turk J Surj 2009; 1: 146-149.
Doğan U, Karabulut Z, Hamamcı O, Sökmensüer C, Ercis S, Korkmaz A. N-asetilsistein’in tıkanma sarılığında bakteriyel translokasyona, karaciğer ve ileumdaki yapısal değişikliklere etkisi. Turk J Surj 2005; 21: 15-20.
Cantürk NZ, Canturk Z, Utkan NZ, Yenisey C, Ozbilim G, Yildirir C, et al. Cytoprotective effects of alpha tocopherol against liver injury induced by extrahepatic biliary obstruction East Afr Med J 1998; 75: 77-80.
Doğan U, Korkmaz A, Erciş S, Doğan H. Tıkanma sarılığı modelinde büyüme hormonunun bakteriyel translokasyona ve karaciğer ile ince barsaktaki yapısal histopatolojik değişiklikler üzerine etkisi. Turk J Surg 2007; 23: 112-116.
Onalan AK, Tuncal S, Kilicoglu S, Celepli S, Durak E, Kilicoglu B, et al. Effect of silymarin on oxidative stress and liver histopathology in experimental obstructive jaundice model Acta Cir Bras 2016; 31: 801-806. [CrossRef] Halverscheid L, Deibert P, Schmidt R, Blum HE, Dunkern T, Pannen BH, et al. Phosphodiesterase-5 inhibitors have distinct effects on the hemodynamics of the liver. BMC Gastroenterol 2009; 18; 9: 69. Tang WH, Zhuang XJ, Ma LL, Hong K, Zhao LM, Liu DF, et al. Effect of sildenafil on erectile dysfunction and improvement in the quality of sexual life in China: a multi-center study. Int J Clin Exp Med 2015; 15; 8: 11539-11543.
Baveja R, Keller S, Yokoyama Y, Sonin N, Clemens MG, Zhang JX. LPS-induced imbalanced expression of hepatic vascular stress genes in cirrhosis: possible mechanism of increased susceptibility to endotoxemia. Shock 2002; 17: 316-321 [CrossRef] Kesici H, Ulusoy AN, Topgül K, Paşaoğlu H, Bayraktar N, Şenyürek G, et al. Tıkanma sarılıklı ratlarda taurolidine’in kolonik anastomoz iyileşmesi üzerine etkisi. Turk J Surg 2007; 23: 001-009.
Akca T, Canbaz H, Tataroglu C, Caglikulekci M, Tamer L, Colak T, et al. The effect of N-acetylcysteine on pulmonary lipid peroxidation and tissue damage. J Surg Res 2005; 129: 38-45. [CrossRef] Aldemir M, Ge