AI Summary & Key Takeaways
AI InsightIn Group 2, 43 (86%) patients recovered, whereas 7 (14%)patients had no recovery (p=0.004).Conclusion: The topical antimicrobial treatment with metronidazole as an addition to the classical medical treatments in acute anal fissure is an effective and safe practice resulting in further reduction in pain and increasedhealing rate.
📌 3 Key Takeaways
Özet
Objective: Acute anal fissure is a very common disorder of the anorectal region. Its most widely used treatmentmethod is the medications given in addition to conservative therapies. The objective of the present study was toinvestigate the effects of local metronidazole use in the treatment of acute anal fissure on the symptoms and remission processes of the patients.Material and Methods: This was a prospective, randomized, controlled clinical study conducted on 100 consecutivepatients who presented to our clinic between March 2016 and March 2017 and who were diagnosed with acuteanal fissure. Patients were randomly divided into two groups of 50 persons. Patients in Group 1 were given only 5%lidocaine pomade as a local anesthesia, and those in Group 2 were given 5% lidocaine pomade and metronidazolecream. Patients applied the medications topically to the anal margin 3 times per day for 4 weeks. Patients’ demographic characteristics, such as age and gender, were recorded. All patients were invited for check-up at the end ofweeks 1, 2, and 4 of treatment. The Visual Analogue Scale scores for pain and the healing status of their fissure byvisual inspection, as well as any adverse effects of the drugs, were recorded. The results were compared statistically.A p-value <0.05 was considered significant.Results: The mean ages of the patients were 34.2±4.1 years in Group 1 and 36.6±3.8 years in Group 2. As a result ofthe statistical comparison of the Visual Analogue Scale scores, there was a statistically significant difference betweenthe two groups at the end of weeks 2 and 4 (p=0.004 and p<0.001, respectively). In Group 1, 28 (56%) patients recovered, but no recovery was observed in 22 (44%) patients. In Group 2, 43 (86%) patients recovered, whereas 7 (14%)patients had no recovery (p=0.004).Conclusion: The topical antimicrobial treatment with metronidazole as an addition to the classical medical treatments in acute anal fissure is an effective and safe practice resulting in further reduction in pain and increasedhealing rate.