Journals / Uludağ Üniversitesi Tıp Fakültesi Dergisi / 2021 / Cilt: 47 - Sayı: 3

Clinicopathological Characteristics of Incidental Prostate Tumors Detected in Radical Cystoprostatectomy Materials

Radikal Sistoprostatektomi Materyalinde İnsidental Prostat Kanseri Saptanan Olguların Klinikopatolojik Özellikleri

Pages
417–421
Publication Date
2021-12-01
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Although an unfavorable clinical course is not observed in patients with incidental prostate tumor, the main determinant of prognosis is the bladder tumor.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Incidental prostate cancers are frequently encountered in radical cystoprostatectomy materials, which are widely used in the treatment of bladder cancer.
📊
Key Findings & Data:We aimed to evaluate incidental prostate cancer’s incidence, stage, histopathological features and their effect on prognosis in patients who underwent radical cystoprostatectomy in our center. 499 patients who underwent radical cystoprostatectomy for bladder cancer between 2006 and 2020 were retrospectively evaluated.
💡
Conclusion & Impact:Although an unfavorable clinical course is not observed in patients with incidental prostate tumor, the main determinant of prognosis is the bladder tumor.
🔬Design:Research Article
📍Scope:2006 Verileri
⚙️Variables:Adenokarsinom · İnsidental · Prostat

Abstract

Incidental prostate cancers are frequently encountered in radical cystoprostatectomy materials, which are widely used in the treatment of bladder cancer. We aimed to evaluate incidental prostate cancer’s incidence, stage, histopathological features and their effect on prognosis in patients who underwent radical cystoprostatectomy in our center. 499 patients who underwent radical cystoprostatectomy for bladder cancer between 2006 and 2020 were retrospectively evaluated. Incidental prostate tumor was detected in 141 (28.3%) cases. All tumors were diagnosed as prostate acinar adenocarcinoma. 127 (90.1%) patients had pT2, 10 (7.1%) patients had pT3a and 4 (2.8%) patients had pT3b tumor. Clinically significant prostate cancer was present in 35 (24.8%) patients. Of the 14 patients with an increased PSA level preoperatively, 4 had a clinically significant prostate tumor. Incidence of incidental prostate tumor is high in radical cystoprostatectomy materials, but most of them are clinically insignificant. The benefit of preoperative evaluation of serum PSA for the detection of incidental tumors is controversial. Although an unfavorable clinical course is not observed in patients with incidental prostate tumor, the main determinant of prognosis is the bladder tumor.

Özet

Mesane kanseri tedavisinde yaygın olarak uygulanan radikal sistoprostatektomi materyallerinde klinik bulgu vermeyen, insidental prostat kanserlerine sıklıkla rastlanmaktadır. Çalışmamızda, merkezimizde radikal sistoprostatektomi uygulanan hastalarda prostat kanseri insidansını, evresini, histopatolojik özellikleri ve bu tümörlerin prognoza etkisini değerlendirmeyi amaçladık. 2006 - 2020 arasında merkezimizde mesane kanseri nedeniyle radikal sistoprostatektomi uygulanan 499 hastaya ait dosyalar retrospektif olarak incelendi. İnsidental prostat tümörü 141 (%28,3) olguda tespit edildi. Tümörlerin tamamı prostat asiner adenokarsinomu olarak tanı aldı. 127 (%90,1) hasta pT2, 10 (%7,1) hasta pT3a ve 4 (%2,8) hasta pT3b tümöre sahipti. 35 (%24,8) hastada klinik olarak önemli prostat kanseri mevcuttu. Ameliyat öncesi artmış PSA değerine sahip 14 hastadan 4’ü klinik olarak anlamlı prostat tümörüne sahipti. Radikal sistoprostatektomi materyallerinde insidental prostat tümörü saptanma oranları yüksektir ancak tümörlerin çoğu klinik olarak önemsiz grupta yer alır. Serum PSA değerinin ameliyat öncesi insidental tümörü tespitinde faydası sınırlıdır. İnsidental prostat tümörüne sahip hastalarda olumsuz klinik seyir izlenmemekle birlikte prognozun asıl belirleyicisi mesane tümörüdür.

🔖

Cite This Article

VURUŞKAN, B. A., YİRMİBEŞ, S., VURUŞKAN, H., YAVAŞCAOĞLU, İ. (2021). Clinicopathological Characteristics of Incidental Prostate Tumors Detected in Radical Cystoprostatectomy Materials. Uludağ Üniversitesi Tıp Fakültesi Dergisi, Cilt: 47 - Sayı: 3, 417–421. https://ajindex.com/articles/380053

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Wu S, Lin SX, Lu M, et al. Assessment of 5-year overall survival in bladder cancer patients with incidental prostate cancer identified at radical cystoprostatectomy. Int Urol Nephrol 2019;51(9):1527–35
  2. Tanaka T, Koie T, Ohyama C, et al. Incidental prostate cancer in patients with muscle-invasive bladder cancer who underwent radical cystoprostatectomy. Jpn J Clin Oncol 2017;47(11):1078–82
  3. Jønck S, Helgstrand JT, Røder MA, et al. The prognostic impact of incidental prostate cancer following radical cystoprostatectomy: a nationwide analysis. Scand J Urol 2018;52(5–6):358–63
  4. Yazici CM, Bozkurt S, Türkeri L, et al. Ortotopik Mesane Yapılan Sistektomide Prostat Korunması Güvenilir Bir Yöntem Midir? Türk Onkol Derg 2005;31(4):485–9
  5. Pan J, Xue W, Sha J, et al. Incidental Prostate Cancer at the Time of Cystectomy: The Incidence and Clinicopathological Features in Chinese Patients. Black PC (ed). PLoS One 2014;9(4):e94490
  6. Filter ER, Gabril MY, Gomez JA, et al. Incidental Prostate Adenocarcinoma in Cystoprostatectomy Specimens: Partial Versus Complete Prostate Sampling. Int J Surg Pathol 2017;25(5):414–20
  7. Abdelhady M, Abusamra A, Pautler SE, Chin JL, Izawa JI. Clinically significant prostate cancer found incidentally in radical cystoprostatectomy specimens. BJU Int 2007;99(2):326–9
  8. Montironi R, Mazzucchelli R, Santinelli A, et al. Incidentally detected prostate cancer in cystoprostatectomies: pathological and morphometric comparison with clinically detected cancer in totally embedded specimens. Hum Pathol 2005;36(6):646–54
  9. Damiano R, Di Lorenzo G, Cantiello F, et al. Clinicopathologic Features of Prostate Adenocarcinoma Incidentally Discovered at the Time of Radical Cystectomy: An Evidence-Based Analysis. Eur Urol 2007;52(3):648–57
  10. Packiam VT, Tsivian M, Avulova S, et al. Long-term outcomes of incidental prostate cancer at radical cystectomy. Urol Oncol Semin Orig Investig 2020;38(11):848.e17-848.e22
  11. Aytac B, Vuruskan H. Clinicopathologic features of incidental prostatic adenocarcinoma in radical cystoprostatectomy specimens. World J Surg Oncol 2011;9(1):81
  12. College of American Pathologists. Cancer Protocol Templates, Prostate Gland. cap.org/cancerprotocols. Accessed May 11, 2021
  13. Epstein JI, Egevad L, Amin MB, et al. The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma. Am J Surg Pathol 2016;40(2):244–52
  14. Epstein JI, Walsh PC, Carmichael M