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Journals / Uludağ Üniversitesi Tıp Fakültesi Dergisi / 2021 / Cilt: 47 - Sayı: 3

Investigation of VMAT-Cyberknife Virtual Treatment Plans in Accelerated Partial Breast Irradiation in Patients with Early Stage Breast Cancer

Erken Evre Meme Kanserli Hastalarda Hızlandırılmış Kısmi Meme Işınlamasında VMAT-CyberKnife Sanal Tedavi Planlarının İncelenmesi

Hidayetül Mediha KILIÇ
Sibel KAHRAMAN ÇETİNTAŞ
Mehmet TOSUN
Metin ZORLUTUNA
Sema Gözcü TUNÇ
Meral KURT
Candan DEMİRÖZ ABAKAY
Pages
357–364
Publication Date
2021-12-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The duration (s) of treatment (p

📌 3 Key Takeaways

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Objective & Hypothesis:It is aimed to compare target volume and critical organ doses by using Volumetric Arc Therapy (VMAT) and CyberKnife techniques in accelerated partial breast irradiation in patients with early stage breast cancer.
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Key Findings & Data:For this study, 10 patients diagnosed with early stage breast cancer who received radiotherapy were selected.
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Conclusion & Impact:The duration (s) of treatment (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:APBI · CyberKnife · Volümetrik ark terapi

Abstract

It is aimed to compare target volume and critical organ doses by using Volumetric Arc Therapy (VMAT) and CyberKnife techniques in accelerated partial breast irradiation in patients with early stage breast cancer. For this study, 10 patients diagnosed with early stage breast cancer who received radiotherapy were selected. VMAT and CyberKnife (SBRT) virtual plans were created with a daily fraction dose of 6 Gy and a total dose of 30 Gy. Homogeneity index (HI), conformity index (CI), treatment duration (s), gross tumor volume (GTV) and dose values received by critical organs were compared. A significant difference was found between the treatment plans in favor of the VMAT technique in the Dmax (p=0.002) value of GTV. It was observed that 30 Gy (V30) (p=0.013) and 15 Gy (V15) values (p=0.007) of the ipsilateral breast received less dose in CyberKnife technique. There was no significant difference in terms of Dmax (p=0.218) of the contralateral breast. No significant difference was found for Dmax (p=0.282) and volume of the heart receiving 1.5 Gy (V1.5) (p=0.548) in cases located in the right breast. There was no significant difference in heart Dmax (p=0.095) in cases located in the left breast; however, the value (p=0.008) of the heart receiving 1.5 Gy (V1.5) was found to be lower in the CyberKnife technique. The duration (s) of treatment (p

Özet

Erken evre meme kanserli hastalarda hızlandırılmış kısmi meme ışınlamasında Volümetrik Ark Terapi (VMAT) ve CyberKnife teknikleri kullanılarak hedef volüm ile kritik organ dozlarının karşılaştırılması amaçlanmıştır. Bu çalışma için radyoterapi almış 10 erken evre meme kanseri tanılı hasta seçilerek, günlük fraksiyon dozu 6 Gy ve toplam doz 30 Gy olacak şekilde VMAT ve CyberKnife (SBRT) sanal planları oluşturuldu. Homojenite indeksi (HI), konformite indeksi (CI), tedavi süresi (s), görünür hedef volümü (GTV) ve kritik organların aldığı doz değerleri karşılaştırıldı. Tedavi planları arasında GTV’nin Dmax (p=0,002) değeri VMAT tekniği lehine anlamlı fark bulundu. Aynı taraf memenin 30 Gy (V30) (p=0,013) ve 15 Gy alan (V15) volüm değerlerinin (p=0,007) CyberKnife tekniğinde daha az doz aldığı görüldü. Karşı memenin Dmax (p=0,218) değeri açısından anlamlı bir fark bulunmamıştır. Sağ meme yerleşimli olgularda kalbin Dmax (p=0,282) ve 1,5 Gy alan (V1,5) volümü için (p=0,548) anlamlı fark bulunmadı. Sol meme yerleşimli olgularda kalbin Dmax (p=0,095) değerinde anlamlı fark görülmedi; ancak kalbin 1,5 Gy alan (V1,5) volüm değerinin (p=0,008) CyberKnife tekniğinde daha düşük olduğu görüldü. Tedavi süresi (s) (p

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Cite This Article

KILIÇ, H. M., ÇETİNTAŞ, S. K., TOSUN, M., ZORLUTUNA, M., TUNÇ, S. G., KURT, M., ABAKAY, C. D. (2021). Investigation of VMAT-Cyberknife Virtual Treatment Plans in Accelerated Partial Breast Irradiation in Patients with Early Stage Breast Cancer. Uludağ Üniversitesi Tıp Fakültesi Dergisi, Cilt: 47 - Sayı: 3, 357–364. https://ajindex.com/articles/380044

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