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Journals / Turkish Journal of Obstetrics and Gynecology / 2016 / Cilt: 13 - Sayı: 3

Hiperemezis gravidarum hastalarında vitamin D ve yüksek hassasiyetli-C reaktif protein seviyeleri değişir mi? Preliminer çalışma

Do vitamin D and high-sensitivity-C reactive protein levels differ in patients with hyperemesis gravidarum? A preliminary study

Saynur YILMAZ
Derya Akdağ CIRIK
Canan DEMİRTAŞ
Hakan TİMUR
Ayşe ŞAHİN
Nuri DANIŞMAN
Dilek UYGUR
Pages
123–126
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Larger studies are required to clarify whether there is a relation between vitamin D deficiency and hyperemesis gravidarum.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: The high sensitivity-C reactive protein (hs-CRP) is an inflammatory marker and vitamin D is an immune modulator that might play a critical role in the pathogenesis of hyperemesis gravidarum.
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Key Findings & Data:Therefore, in the current study, we tested the hypothesis that suggests women with hyperemesis gravidarum have lower 25-hydroxyvitamin D levels and higher hs-CRP levels, compared to controls.
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Conclusion & Impact:Larger studies are required to clarify whether there is a relation between vitamin D deficiency and hyperemesis gravidarum.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: The high sensitivity-C reactive protein (hs-CRP) is an inflammatory marker and vitamin D is an immune modulator that might play a critical role in the pathogenesis of hyperemesis gravidarum. Therefore, in the current study, we tested the hypothesis that suggests women with hyperemesis gravidarum have lower 25-hydroxyvitamin D levels and higher hs-CRP levels, compared to controls. Materials and Methods: This prospective case-control study included 30 women with hyperemesis gravidarum (study group) and 30 age- and body mass index-matched healthy women (control group). The levels of 25-hydroxyvitamin D and hs-CRP were compared between two groups.Results: Both the serum 25-hydroxyvitamin D (5.30 µg/L vs. 6.44 µg/L; p=0.09) and hs-CRP levels (0.29 mg/dL vs. 0.47 mg/dL; p=0.93) were not significantly different between the study and control groups. Vitamin D deficiency was present in 27 (90.0%) women in the study group and 22 (73.3%) women in the control group (p=0.181). There was also no correlation between 25-hydroxyvitamin D and hs-CRP levels in both groups.Conclusion: Although it did not reach statistical significance, vitamin D levels were lower in the study group compared with controls. Therefore, vitamin D might be speculated to play a crucial role in controlling the inflammatory status associated with hyperemesis gravidarum. Larger studies are required to clarify whether there is a relation between vitamin D deficiency and hyperemesis gravidarum.

Özet

Amaç: Yüksek hassasiyetli C reaktif protein (hs-CRP) bir enflamatuvar belirteçtir ve vitamin D ise hiperemezis gravidarum patogenezinde kritik rol oynayan bir immünmodülatördür. Bu nedenle, bizde bu çalışmada hiperemezis gravidarumlu kadınlarda kontrollere göre daha düşük 25 hidroksivitamin D ve daha yüksek hs-CRP seviyeleri olma hipotezini test ettik.Gereç ve Yöntemler: Bu prospektif olgu kontrol çalışmasına hiperemezis gravidarumlu 30 gebe (olgu grubu) ve yaş, vücut kitle indeksi ile eşleştirilmiş 30 sağlıklı gebe (kontrol grubu) dahil edildi. İki grup arasında 25-hidroksivitamin D ve hs-CRP seviyeleri karşılaştırıldı. Bulgular: Olgu ve kontrol grupları arasında serum 25-hidroksivitamin D (5,30 µg/L vs. 6,44 µg/L; p=0,09) ve hs-CRP (0,29 mg/dL vs. 0,47 mg/dL; p=0,93) seviyeleri farklı değildi. Olgu grubunda vitamin D eksikliği 27 (%90) hastada görülür iken, kontrol grubunda 22 (%73,3) hastada görülmekte idi (p=0,181). İki grupta da 25-hidroksivitamin D ve hs-CRP seviyeleri arasında korelasyon yoktu.Sonuç: İstatistiksel olarak anlamlı olmasa da vitamin D seviyeleri olgu grubunda kontrollere göre daha düşüktür. Bu nedenle vitamin D'nin hiperemezis gravidarumdaki enflamatuvar süreci kontrol etmekte etkin bir rol oynadığı speküle edilebilir. Vitamin D eksikliği ve hiperemezis gravidarum arasındaki ilişkiyi netleştirmek için daha geniş hasta sayılı çalışmalara ihtiyaç vardır.

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Cite This Article

YILMAZ, S., CIRIK, D. A., DEMİRTAŞ, C., TİMUR, H., ŞAHİN, A., DANIŞMAN, N., UYGUR, D. (2016). Hiperemezis gravidarum hastalarında vitamin D ve yüksek hassasiyetli-C reaktif protein seviyeleri değişir mi? Preliminer çalışma. Turkish Journal of Obstetrics and Gynecology, Cilt: 13 - Sayı: 3, 123–126. https://ajindex.com/articles/376433

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