Practical and cost-effective methods should be found or larger patient series should be investigated.
📌 3 Key Takeaways
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Objective & Hypothesis:Objective: The aim of this study was to diagnose ectopic pregnancy in the early period by measuring cell-free fetal DNA (cffDNA) levels in maternal blood using spectrophotometry.Materials and Methods: Thirty patients with ectopic pregnancy and 30 patients with first trimester intrauterine pregnancy were enrolled in this prospective controlled study. cffDNA levels in maternal serum were measured using spectrophotometry.Results: There were no differences between the two groups in terms of cffDNA absorbance levels.Conclusion: Spectrophotometry is not suitable for measuring cffDNA levels to diagnose ectopic pregnancies in the early period.
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Key Findings & Data:Objective: The aim of this study was to diagnose ectopic pregnancy in the early period by measuring cell-free fetal DNA (cffDNA) levels in maternal blood using spectrophotometry.Materials and Methods: Thirty patients with ectopic pregnancy and 30 patients with first trimester intrauterine pregnancy were enrolled in this prospective controlled study. cffDNA levels in maternal serum were measured using spectrophotometry.Results: There were no differences between the two groups in terms of cffDNA absorbance levels.Conclusion: Spectrophotometry is not suitable for measuring cffDNA levels to diagnose ectopic pregnancies in the early period.
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Conclusion & Impact:Practical and cost-effective methods should be found or larger patient series should be investigated.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Objective: The aim of this study was to diagnose ectopic pregnancy in the early period by measuring cell-free fetal DNA (cffDNA) levels in maternal blood using spectrophotometry.Materials and Methods: Thirty patients with ectopic pregnancy and 30 patients with first trimester intrauterine pregnancy were enrolled in this prospective controlled study. cffDNA levels in maternal serum were measured using spectrophotometry.Results: There were no differences between the two groups in terms of cffDNA absorbance levels.Conclusion: Spectrophotometry is not suitable for measuring cffDNA levels to diagnose ectopic pregnancies in the early period. Practical and cost-effective methods should be found or larger patient series should be investigated.
Özet
Amaç: Ektopik gebelik tanısının erken dönemde spektrofotometrik yöntemle anne kanından serbest fetal DNA (cffDNA) ölçülerek konulmasıdır.Gereç ve Yöntemler: Bu prospektif kontrollü çalışmada 30 adet ektopik gebelik tanısı almış hasta ile 30 adet ilk trimester intrauterin gebe cffDNA değerleri açısından spektrofotometrik yöntem kullanılarak karşılaştırıldı.Bulgular: İki grup arasında cffDNA absorbans değerleri bakımından anlamlı fark bulunmadı.Sonuç: Spektrofotometrik yöntemle cffDNA ölçümü ucuz ve basit bir yöntem olmasına rağmen ektopik gebeliğin erken tanısında yararlı bulunmamıştır. Polimeraz zincir reaksiyonu ya da daha hassas sitogenetik araştırmalar kullanılabilir; ancak maliyet etkinliği açısından uygun olmayabilir.
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Cite This Article
KARUSERCİ, Ö. K., UĞUR, M. G., BALAT, Ö., SUCU, S. (2017). No increase in free fetal DNA level in ectopic pregnancy: A preliminary study. Turkish Journal of Obstetrics and Gynecology, Cilt: 14 - Sayı: 3, 156–159. https://ajindex.com/articles/376424
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