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Journals / Turkish journal of vascular surgery / 2019 / Cilt: 28 - Sayı: 3

Evaluation of oxidative and antioxidant markers in the blood samples of patients with abdominal aorta pathology

Fevzi Sarper TÜRKER
Mine ERİŞİR
Pages
151–158
DOI
—
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⚡ TL;DR(Too Long; Didn't Read)

In the light of these results, we conclude that the GSH activity is not sufficientto compensate the existing damage and the low CAT activity in all groups may show that it has a role in the development of the disease.

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Objective & Hypothesis:Objectives: This study aims to investigate the effects of oxidative damage on the development of the disease in patients scheduled for surgeryfor aortoiliac occlusive disease (AOD) and abdominal aortic aneurysm (AAA).Patients and methods: Between June 2015 and July 2016, a total of 24 patients (22 males, 2 females; mean age 63.2±10.4 years; range, 41to 76 years) who admitted to our clinic for surgery were included in the study.
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Key Findings & Data:The control group (n=100) consisted of healthy volunteers including health care personnel, particularly physicians working in thehospital.
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Conclusion & Impact:In the light of these results, we conclude that the GSH activity is not sufficientto compensate the existing damage and the low CAT activity in all groups may show that it has a role in the development of the disease.
🔬Design:Research Article
📍Scope:2015 Verileri
⚙️Variables:Domain Parameters

Özet

Objectives: This study aims to investigate the effects of oxidative damage on the development of the disease in patients scheduled for surgeryfor aortoiliac occlusive disease (AOD) and abdominal aortic aneurysm (AAA).Patients and methods: Between June 2015 and July 2016, a total of 24 patients (22 males, 2 females; mean age 63.2±10.4 years; range, 41to 76 years) who admitted to our clinic for surgery were included in the study. The study group consisted of all elective AOD and AAApatients. The control group (n=100) consisted of healthy volunteers including health care personnel, particularly physicians working in thehospital. We obtained blood samples before surgery and compared levels of malondialdehyde (MDA) as an indicator of oxidative damage,and the levels of certain antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH) with theblood levels of healthy volunteers.Results: The comparison of the patient and healthy volunteer groups showed that blood MDA levels increased due to the oxidative damage(p=0.001). Regarding the antioxidant activity, we found that GSH levels increased in the patient group; however, the SOD activity remainedunchanged. The CAT activity was statistically significantly decreased in the patient group (p=0.001).Conclusion: The increased oxidative damage levels (MDA) in all patient groups compared to healthy individuals may indicate that oxidativestress has an important role in the development of the disease. In the light of these results, we conclude that the GSH activity is not sufficientto compensate the existing damage and the low CAT activity in all groups may show that it has a role in the development of the disease.

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Cite This Article

TÜRKER, F. S., ERİŞİR, M. (2019). Evaluation of oxidative and antioxidant markers in the blood samples of patients with abdominal aorta pathology. Turkish journal of vascular surgery, Cilt: 28 - Sayı: 3, 151–158. https://ajindex.com/articles/375809

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References (14)

  1. Pincemail J, Defraigne JO, Cheramy-Bien JP, Dardenne N, Donneau AF, Albert A, et al. On the potential increase of the oxidative stress status in patients with abdominal aortic aneurysm. Redox Rep 2012;17:139-44.
  2. Parastatidis I, Weiss D, Joseph G, Taylor WR. Overexpression of catalase in vascular smooth muscle cells prevents the formation of abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol 2013;33:2389-96.
  3. Rajagopalan S, Meng XP, Ramasamy S, Harrison DG, Galis ZS. Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability. J Clin Invest 1996;98:2572-9.
  4. Li PF, Dietz R, von Harsdorf R. Reactive oxygen species induce apoptosis of vascular smooth muscle cell. FEBS Lett 1997;404:249-52.
  5. Wiernicki I, Parafiniuk M, Kolasa-Wolosiuk A, Gutowska I, Kazimierczak A, Clark J, et al. Relationship between aortic wall oxidative stress/proteolytic enzyme expression and intraluminal thrombus thickness indicates a novel pathomechanism in the progression of human abdominal aortic aneurysm. FASEB J 2019;33:885-95.
  6. Förstermann U, Xia N, Li H. Roles of Vascular Oxidative Stress and Nitric Oxide in the Pathogenesis of Atherosclerosis. Circ Res 2017;120:713-35.
  7. McCormick ML, Gavrila D, Weintraub NL. Role of oxidative stress in the pathogenesis of abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol 2007;27:461-9.
  8. Nordon IM, Hinchliffe RJ, Loftus IM, Thompson MM. Pathophysiology and epidemiology of abdominal aortic aneurysms. Nat Rev Cardiol 2011;8:92-102.
  9. Indes JE, Pfaff MJ, Farrokhyar F, Brown H, Hashim P, Cheung K, et al. Clinical outcomes of 5358 patients undergoing direct open bypass or endovascular treatment for aortoiliac occlusive disease: a systematic review and meta-analysis. J Endovasc Ther 2013;20:443-55.
  10. Norgren L, Hiatt WR, Dormandy JA, Nehler MR, Harris KA, Fowkes FG, et al. Inter-society consensus for the management of peripheral arterial disease. Int Angiol 2007;26:81-157. Weintraub NL. Understanding abdominal aortic aneurysm. N Engl J Med 2009;361:1114-6.
  11. Aggarwal S, Qamar A, Sharma V, Sharma A. Abdominal aortic aneurysm: a comprehensive review. Exp Clin Cardiol 2011;16:11-5.
  12. Sugamura K, Keaney JF Jr. Nicotine: linking smoking to abdominal aneurysms. Nat Med 2012;18:856-8.
  13. Lindsay ME, Dietz HC. Lessons on the pathogenesis of aneurysm from heritable conditions. Nature 2011;473:308-16.
  14. Lucas ML, Carraro CC, Belló-Klein A, Kalil