Prevalence of Vitamin D Deficiency in Healthy Adults

Key Findings & Data:Material-methods: The 25(OH) vitD3 test results of 2007 patients admitted to Selçuk University Medicine Faculty hospital between the years of 2015 and 2016 were analyzed, retrospectively.

💡

Conclusion & Impact:Results: Our results show that the prevalence of vitamin D deficiency is about 67.9% in our society.

🔬Design:Research Article

📍Scope:2007 · 2007 hasta

⚙️Variables:Vitamin D deficiency · LC/MS/MS · prevalence

Abstract

Objectives: Vitamin D is a well-known hormone and important for many metabolic pathways and different health outcomes. The physiology of vitamin D is very complex. Multiple factors like ethnicity, age, sex, diseases, and medication influence vitamin D concentrations. In this study, our aim was to determine the prevalence of vitamin D deficiency among adults in Turkey. Material-methods: The 25(OH) vitD3 test results of 2007 patients admitted to Selçuk University Medicine Faculty hospital between the years of 2015 and 2016 were analyzed, retrospectively. Patients using any vitamin D consisting drug, having chronic disease and inflammatory disorders were excluded. Vitamin D levels were measured by a chromatographic method (LC/MS/MS) with API3200 which is the gold standard to measure 25(OH)D3. Results: Our results show that the prevalence of vitamin D deficiency is about 67.9% in our society. The mean value of vitamin D was 16,87 ng/mL and females had significantly lower 25(OH)D3 levels compared to males (p<0.001).The 25(OH)D3 levels were higher in summer and in fall than in winter and spring. (p<0.001) Conclusıons: The results indicate that vitamin D deficiency is prevalent in this study population despite high levels of sunshine and UV radiation throughout the year. Preventive treatments should be planned.Amaç: D vitamini, birçok metabolik yolakta rol alan ve bazı hastalıklarla ilişkili olan bir hormondur. Vitamin D fizyolojisi çok karmaşıktır. Etnik köken, yaş, cinsiyet, hastalıklar ve ilaç kullanımı vitamin D konsantrasyonunu etkilemektedir. Bu çalışmada amacımız Türkiye’de sağlıklı erişkinlerde vitamin D eksikliği sıklığını belirlemekti. Yöntem: 2015-2016 yılları arasında Selçuk Üniversitesi Tıp Fakültesi Hastanesi'ne başvuran 2007 hastanın 25(OH)D3 test sonuçları retrospektif olarak incelendi. Vitamin D içeren ilaç kullanan, kronik hastalık veya enflamatuar hastalıkları olan hastalar çalışma dışı bırakılmıştır. D vitamini seviyeleri, 25(OH)D3 ölçmek için altın standart olan kromatografik yöntemle (LC / MS / MS) API3200 cihazı ile ölçülmüştür. Sonuçlar: Bulgularımız, çalışma popülasyonumuzda D vitamini eksikliği prevalansının yaklaşık %67,9 olduğunu göstermektedir. D vitamini ortalama değeri 16,87 ng/mL idi ve kadınlarda 25(OH)D3 seviyeleri, erkeklere göre anlamlı derecede düşüktü (p <0,001). Yaz ve sonbahar mevsiminde 25 (OH) D3 seviyeleri, kış ve ilkbahar mevsimine göre daha yüksekti.(p <0.001) Tartışma: Sonuçlarımız yıl boyunca yüksek düzeyde güneş ve UV ışığına rağmen, D vitamini eksikliğinin popülasyonumuzda yaygın olduğunu göstermektedir. Önleyici tedaviler planlanmalıdır.

Keywords

Vitamin D deficiency LC/MS/MS prevalence

🔖

Cite This Article

HATAYSAL, E. P., SARAÇLIGİL, B., ABUŞOĞLU, S., ÜNLÜ, A., VATANSEV, H. (2019). Prevalence of Vitamin D Deficiency in Healthy Adults. Turkish Journal of Family Medicine and Primary Care, Cilt: 13 - Sayı: 3, 335–341. https://ajindex.com/articles/374060

📄 Full Text PDF Viewer

Open in New Tab ↗

↗New Tab

📄

PDF görüntüleyici hazırlanıyor...

References (10)

Heaney RP, Dowell MS, Hale CA, Bendich A. Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D. J Am Coll Nutr 2003;22:142-146
Wacker M, Holick MF. Sunlight and vitamin D: a global perspective for health. Dermato-Endocrinol. 2013;5(1):51–108
Holick MF. The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention. Rev Endocr Metab Disord (2017) 18:153–165 DOI 10.1007/s11154-017-9424-1 4. Altieri B, Muscogiuri G, Barrea L, Mathieu C, Vallone CV, Mascitelli L et al. Rev Endocr Metab Disord. Does vitamin D play a role in autoimmune endocrine disorders? A proof of concept. (2017) Sep;18(3):335-346. doi: 10.1007/s11154-016-9405-9
Battault S, Whiting SJ, Peltier SL, Sadrin S, Gerber G, Maixent JM. Vitamin D metabolism, functions, and needs: from science to health claims. Eur J Nutr (2013) 52:429–441 DOI 10.1007/s00394-012-0430-5 6. Palacios C, Gonzalez L. Is vitamin D deficiency a major global public health problem? J Steroid Biochem Mol Biol. 2014 October; 144PA: 138–145. doi:10.1016/j.jsbmb.2013.11.003 7. Daly RM, Gagnon C, Lu ZX, et al. Prevalence of vitamin D deficiency and its determinants in Australian adults aged 25 years and older: a national, population-based study. Clin Endocrinol. 2012; 77:26–35
Antico A, Tampoia M, Tozzoli R, Bizzaro N. Can supplementation with vitamin D reduce the risk or modify the course of autoimmune diseases? A systematic review of the literature. Autoimmun Rev 2012; 12:127-36; PMID:22776787;
Holick MF. Vitamin D deficiency. N Engl J Med 2007; 357:266–81
Granlund L, Ramnemark A, Andersson C et al. Prevalence of vitamin D deficiency and its association with nutrition, travelling and clothing habits in an immigrant population in Northern Sweden. European Journal of Clinical Nutrition (2016) 70, 373–37 11. Holick MF, Siris ES, Binkley N, et al. Prevalence of vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy. J Clin Endocrinol Metab 2005; 90:3215–24
Binkley N, Krueger D, Cowgill CS et al. Assay variation confounds the diagnosis of hypovitaminosis D: a call for standardization. J Clin Endocrinol Metab 2004; 89:3152–7
Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences- Am J Clin Nutr. 2008 Apr;87(4):1080S-6S 14. Pearce SH, Cheetham TD. Diagnosis and management of vitamin D deficiency. BMJ 2010; 340: b5664
Rosen CJ,