Determination of serum YKL-40 levels in patients with brucellosis

Key Findings & Data:Material and Methods: This study included 40 Brucellosis patients with positive serum agglutination tests and 41 healthy control subjects.

💡

Conclusion & Impact:However, further studies are needed for the role of YKL-40 in infectious diseases to be understood more clearly.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Bruselloz · YKL-40 · infeksiyon

Abstract

Aim: To determine serum YKL-40 levels in patients diagnosed with brucellosis. Material and Methods: This study included 40 Brucellosis patients with positive serum agglutination tests and 41 healthy control subjects. The two groups were compared with regard to their serum YKL-40, hematological parameters, and C-reactive protein (CRP) values. Results: The brucellosis patient group presented YKL-40 values of 15.0 ± 8.8 ng/mL, CRP values of 0.2 ± 0.1 mg/dL, a Neutrophil/Lymphocyte ratio (NLR) of 1.5 ± 1.0, and a Platelet/Lymphocyte ratio (PLR) of 109.3 ± 46.4. The control group presented YKL-40 values of 12.7 ± 6.1ng/mL, CRP values of 1.48 ± 2.1mg/dL, a Neutrophil/Lymphocyte ratio (NLR) of 2.1 ± 0.7, and a Platelet/Lymphocyte ratio (PLR) of 147.8 ± 59.0. Conclusion: No significant differences were determined between the YKL-40 levels of the patient and control groups. The patient group manifested significantly higher levels of CRP compared to the control group, and YKL-40 was determined to be positively correlated with CRP, PLT, PLR, NLR and age. However, further studies are needed for the role of YKL-40 in infectious diseases to be understood more clearly.

Özet

Amaç: Bruselloz tanılı hastalarda serum YKL-40 düzeylerini belirlemek. Gereç ve Yöntemler: Bu çalışmaya serum aglütinasyon testi pozitif 40 Bruselloz hastası ve 41 sağlıklı kontrol grubu dahil edilmiştir. İki grup arasında serum YKL-40, hematolojik parametreler ve C reaktif protein (CRP) değerleri karşılaştırılmıştır. Bulgular: Bruselloz hasta grubunda, YKL-40 değeri 15.0 ± 8.8 ng/mL, CRP 0.2 ± 0.1 mg/dL, Nötrofil/ Lenfosit oranı (NLR) 1.5 ± 1.0 ve Platelet/Lenfosit oranı (PLR) 109.3 ± 46.4 idi. Kontrol grubunda, YKL-40 değeri 12.7 ± 6.1ng/mL, CRP 1.48 ± 2.1mg/dL, Nötrofil/ Lenfosit oranı (NLR) 2.1 ± 0.7 ve Platelet/Lenfosit oranı (PLR) 147.8 ± 59.0 idi. Sonuç: YKL-40 düzeylerinde hasta ve kontrol grubu arasında anlamlı bir fark bulunmamıştır. Hasta grubunda kontrol grubuna göre CRP anlamlı olarak yüksek, bunun yanında YKL-40 ile CRP, PLT, PLR, NLR ve yaş arasında pozitif korelasyon saptanmıştır. Ancak YKL-40’ ın enfeksiyon hastalıklarında rolünün daha iyi anlaşılabilmesi için ileri çalışmalara ihtiyaç vardır.

Keywords

Bruselloz YKL-40 infeksiyon brucellosis diagnostic value

🔖

Cite This Article

SEZGİN, F. M., NAR, R. (2019). Determination of serum YKL-40 levels in patients with brucellosis. Turkish Journal of Clinics and Laboratory, Cilt: 10 - Sayı: 3, 335–339. https://ajindex.com/articles/372963

📄 Full Text PDF Viewer

Open in New Tab ↗

↗New Tab

📄

PDF görüntüleyici hazırlanıyor...

References (14)

EJ Y. Brucella species. In: Mandell GL, Bennet JE, Dolin R, (eds). Principles and Practice of Infectious Diseases. 6th ed. New York: Churchill Livingstone, 2005: 2669-72
Hussein MZ, Abou-Elnoeman SA, Al-Fikky AA, El-Samadouny EI, Shaaban AAM. Evaluation of Rose Bengal Test, Standard Tube Agglutination Test and Nested PCR for the diagnosis of Human Brucellosis. Egypt J Med Microbiol 2006; 15: 249-56
Seleem MN, Boyle SM, Sriranganathan N. Brucellosis: a re-emerging zoonosis. Vet Microbiol 2010; 140: 392-8
Galinska EM, Zagorski J. Brucellosis in humans-etiology, diagnostics, clinical forms, Ann Agric Environ Med 2013; 20: 233–38
Hekmatimoghaddam S, Sadeh M, Khalili MB, Mollaabedin M, Sazmand A. Comparison of PCR, Wright agglutination test and blood culture for diagnosis of brucellosis in suspected patients. Pak J Biol Sci 2013; 16: 1589–92
Gomez MC, Nieto JA, Rosa C, Geijo P et al. Evaluation of seven tests for diagnosis of human brucellosis in an area where the disease is endemic. Clin Vaccine Immunol 2008; 15: 1031-33
Asaad AM, Alqahtani JM. Serological and molecular diagnosis of human brucellosis in Najran, Southwestern Saudi Arabia. J Infect Public Health 2012; 5: 189-94
Olt S, Ergenc H, Acikgoz SB. Predictive contribution of neutrophil/lymphocyte ratio in diagnosis of brucellosis. Biomed Res Int 2015; 2015: 210502. 9. Łata E, Gisterek I, Matkowski R, Szelachowska J, Kornafel J. The importance of determining the prognostic marker YKL-40 in serum and tissues. Pol Merkur Lekarski 2010; 28: 505-8
Roslind A, Johansen JS. YKL-40: a novel marker shared by chronic inflammation and oncogenic transformation. Methods Mol Biol 2009; 511: 159-84
Libreros S, Iragavarapu-Charyulu V. YKL-40/CHI3L1 drives inflammation on the road of tumor progression. J Leukoc Biol 2015; 98: 931-36
Faibish M, Francescone R, Bentley B, Yan W, Shao R. A YKL-40- neutralizing antibody blocks tumor angiogenesis and progression: a potential therapeutic agent in cancers. Mol Cancer Ther 2011; 10: 742-51
Volck B, Johansen JS, Stoltenberg M et al. Studies on YKL-40 in knee joints of patients with rheumatoid arthritis and osteoarthritis. Involvement of YKL-40 in the joint pathology. Osteoarthritis Cartilage 2001; 9: 203–14
Matsumoto T, Tsurumoto T. Serum YKL-40 levels in rheumatoid arthritis: correlations between clinical and laborarory parameters. Clin Exp Rheumatol 2001: 19; 655–60
Vind I, Johansen, JS, Price PA, Munkholm P. Serum YKL-