Journals / Turkish Journal of Clinics and Laboratory / 2019 / Cilt: 10 - Sayı: 3

Bee venom: A medical perspective

Arı zehri: Tıbbi bakış

Pages
414–421
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It seems bioactive components of BV may open new doors in treatment of various diseases.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Apitherapy is a complementary medical technique that has an old history and is applied in various diseases worldwide.
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Key Findings & Data:Apitherapeutical applications are not treatment methods by themself, but theycan be substantial parts of multidisciplinary approaches.
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Conclusion & Impact:It seems bioactive components of BV may open new doors in treatment of various diseases.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Apiterapi · Apitoksin · Arı Zehri Tedavisi

Abstract

Apitherapy is a complementary medical technique that has an old history and is applied in various diseases worldwide. Apitherapeutical applications are not treatment methods by themself, but theycan be substantial parts of multidisciplinary approaches. One of them, bee venom therapy, is a currently-applied method worldwide. Bee venom (BV) includes several substances such as peptides, phospholipids, bioactive amines, amino acids, sugars, pheromones, enzymes and minerals.Studies on whole BV and its singular components indicated that they have a huge potential in anti-inflammatory, anti-arthritis, anti-nociceptive, neuroprotective, anti-tumoral, anti-microbial, anti-diabetic and anti-rheumatic activities.Results of in vivo studies against arthritis, Parkinson’s and Alzheimer’s disease andcancer are very promising, and also in vitro results indicating other activities such as antimicrobial effect are observed. Although mechanisms of action and many bioactive substances still remains unclear, beneficial effects and potential utilities in certain medical conditions are obvious. It seems bioactive components of BV may open new doors in treatment of various diseases.

Özet

Apiterapi, dünya çapında çok sayıda hastalığın tedavisinde kullanılan ve kökeni çok eski tıbbi kayıtlara dayanan bir tamamlayıcı tıp uygulamasıdır. Apiterapötik teknikler kendi başlarına tedavi yöntemleri değil, aslında, çok disiplinli tıbbi yaklaşımın bir parçasıdırlar. Bu yöntemlerden biri, arı zehri tedavisi, dünyada şu anda uygulanan bir tekniktir. Arı zehri, peptitler, fosfolipitler, biyoaktif aminler, amino asitler, şekerler, feromonlar, enzimler ve mineraller gibi çok sayıda madde içermektedir. Arı zehrinin tümü ve içerdiği materyallere ayrı ayrı yapılan çalışmalarda, bunların, antiinflamatuvar, antiartrit, antinosiseptif, nöroprotektif, antitümöral, antimikrobiyal, antidiyabetik ve antiromatizmal etki potantisiyeli açıkça gösterilmiştir. Artrit, Parkinson ve Alzheimer hastalığı ile kansere yönelik in vivo çalışmalar ile antimikrobiyal etkinlik gibi in vitro çalışmalarda son derece umut verici sonuçlar gözlenmiştir. Her ne kadar etki mekanizması ve birçok biyoaktif içeriği henüz aydınlatılmamış olsa da, belirli tıbbi durumlarda etkinliği açıkça görülmüştür. Arı zehrinin biyoaktif komponentlerinin diğer başka hastalıklar için de yeni kapılar açacağı düşünülmektedir.

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Cite This Article

SIĞ, A. K., GÜNEY, M., SIĞ, Ö. Ö., ŞAN, H. (2019). Bee venom: A medical perspective. Turkish Journal of Clinics and Laboratory, Cilt: 10 - Sayı: 3, 414–421. https://ajindex.com/articles/372808

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References (16)

  1. Shimpi R, Chaudhari P, Deshmukh R, Devare S, Bagad Y, Bhurat MA. A review: pharmacotherapeutics of bee venom. World J Pharm Pharm Sci 2016; 5: 656-67
  2. Kim CMH. Apitherapy – Bee Venom Therapy. In: Grassberger M, Sherman RA, Gileva OS, Kim CMH, Mumcuoglu KY (eds). Biotherapy-history, principles and practice: A practical guide to the diagnosis and treatment of disease using living organisms. Springer Science & Business Media, Amsterdam 2013; 77-112
  3. Lee JD, Park HJ, Chae Y, Lim S. An overview of bee venom acupuncture in the treatment of arthritis. Evid Based Complement Alternat Med 2005; 2:79-84
  4. Lee MS, Pittler MH, Shin BC, Kong JC, Ernst E. Bee venom acupuncture for musculoskeletal pain: a review. J Pain 2008; 9:289-97
  5. Son DJ, Lee JW, Lee YH, Song HS, Lee CK, Hong JT. Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds. Pharmacol Ther 2007; 115: 246-70
  6. Behroozi J, Divsalar A, Saboury AA. Honey bee venom decreases the complications of diabetes by preventing hemoglobin glycation. J Mol Liq 2014; 199: 371-75
  7. Oršolić N. Bee venom in cancer therapy. Cancer Metastasis Rev 2012; 31: 173-94
  8. Chang YH, Bliven ML. Anti-arthritic effect of bee venom. Agents Actions 1979; 9: 205-11
  9. Raghuraman H, Chattopadhyay A. Melittin: a membrane-active peptide with diverse functions. Biosci Rep 2007; 27: 189-223
  10. Gajski G, Garaj-Vrhovac V. Melittin: a lytic peptide with anticancer properties. Environ Toxicol Pharmacol 2013; 36: 697-705
  11. Alvarez-Fischer D, Noelker C, Vulinović F et al. Bee venom and its component apamin as neuroprotective agents in a Parkinson disease mouse model. PloS One 2013; 8: 61700
  12. Yang EJ, Kim SH, Yang SC, Lee SM, Choi SM. Melittin restores proteasome function in an animal model of ALS. J Neuroinflammation 2011; 8: 69
  13. Cornara L, Biagi M, Xiao J, Burlando B. Therapeutic properties of bioactive compounds from different honeybee products. Front Pharmacol 2017; 8: 412
  14. Rady I, Siddiqui IA, Rady M, Mukhtar H. Melittin, a major peptide component of bee venom, and its conjugates in cancer therapy. Cancer Lett 2017; DOI:10.1016/j.canlet.2017.05.010
  15. Hu H, Chen D, Li Y, Zhang X. Effect of polypeptides in bee venom on growth inhibition and apoptosis induction of the human hepatoma cell line SMMC‐7721 in‐vitro and Balb/c nude mice in‐vivo. J Pharm Pharmacol 2006; 58: 83-89
  16. Yang ZL, Ke YQ, Xu RX, Peng P. Melittin inhibits