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Journals / Turkish Journal of Endocrinology and Metabolism / 2016 / Cilt: 20 - Sayı: 1

Toksik Multinodüler Guatrda Çok Uzun Süreli Propiltiourasil Kullanımına Bağlı Nötropeni

Neutropenia Due to Very Long Time Propylthiouracil Usage in Toxic Multinodular Goiter

ELİF TURAN
Ahmet KAYA
MUSTAFA KULAKSIZOĞLU
Bahar KANDEMİR
İBRAHİM ERAYMAN
Pages
16–18
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Postoperative pathology was evaluated as micropapillary thyroid carcinoma.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Thyrotoxicosis affects hematopoiesis in several ways and thioamides may cause myelosuppression.
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Key Findings & Data:We report a case of febrile neutropenia in a patient with hyperthyroidism who was using propylthiouracil for nearly 20 years for the treatment of toxic multinodular goitre.
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Conclusion & Impact:Postoperative pathology was evaluated as micropapillary thyroid carcinoma.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Thyrotoxicosis affects hematopoiesis in several ways and thioamides may cause myelosuppression. We report a case of febrile neutropenia in a patient with hyperthyroidism who was using propylthiouracil for nearly 20 years for the treatment of toxic multinodular goitre. After surgery, the patient was euthyroid and neutropenia resolved. Postoperative pathology was evaluated as micropapillary thyroid carcinoma.

Özet

Tirotoksikoz çeşitli yollarla hemtopoezi etkiler ve tionamidlerle birlikte miyelosupresyona neden olabilir. Toksik multinodüer guatra bağlı 20 yıl gibi uzun bir süre propiltiourasil kullanan ve febril nötropeni nedeniyle hastaneye yatışı yapılan hipertirodili bir hasta sunduk. Total tiroidektomi olduktan sonra hasta ötiroid iken nötropenisi düzeldi. Postoperatif patoloji ise mikropapiller tiroid karsinomu olarak değerlendirildi.

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Cite This Article

TURAN, E., KAYA, A., KULAKSIZOĞLU, M., KANDEMİR, B., ERAYMAN, İ. (2016). Toksik Multinodüler Guatrda Çok Uzun Süreli Propiltiourasil Kullanımına Bağlı Nötropeni. Turkish Journal of Endocrinology and Metabolism, Cilt: 20 - Sayı: 1, 16–18. https://ajindex.com/articles/370851

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References (11)

  1. Irvine WJ, Wu FC, Urbaniak SJ, Toolis F. Peripheral blood leucocytes in thyrotoxicosis (Graves' disease) as studied by conventional light microscopy. Clin Exp Immunol 1977;27:216-221.
  2. Reddy J, Brownlie BE, Heaton DC, Hamer JW, Turner JG. The peripheral blood picture in thyrotoxicosis. N Z Med J. 1981;93:143-145. Sprikkelman A, de Wolf JT, Vellenga E. The application of hematopoietic growth factors in drug-induced agranulocytosis: A review of 70 cases. Leukemia 1994;8:2031-2036.
  3. Hegazi M, Kumar R, Bitar Z, Ibrahim E. Pancytopenia related to Graves' disease. Ann Saudi Med 2008;28:48-49.
  4. Lima CS, Zantut Wittmann DE, Castro V, Tambascia MA, Lorand-Metze I, Saad ST, Costa FF. Pancytopenia in untreated patients with Graves' disease. Thyroid 2006;16:403-409. Trotter WR. The relative toxicity of antithyroid drugs. J New Drugs 1962;2:333-343. Rosove MH. Agranulocytosis and antithyroid drugs. West J Med 1977;126:339-343. Cooper DS. Antithyroid drugs. N Engl J Med 2005;352:905-917.
  5. Sun MT, Tsai CH, Shih KC. Antithyroid drug-induced agranulocytosis. J Chin Med Assoc 2009;72:438-441.
  6. Tajiri J, Noguchi S, Murakami T, Murakami N. Antithyroid drug-induced agranulocytosis. The usefulness of routine white blood cell count monitoring. Arch Intern Med 1990;150:621-624.
  7. Croke AR, Berry JW. Agranulocytosis occurring during methimazole therapy. J Am Med Assoc 1951;145:45-47.
  8. Shiran A, Shechner C, Dickstein G. Propylthiouracil-induced agranulocytosis in four patients previously treated with the drug. JAMA 1991;266:3129-3130.
  9. Toth EL, Mant MJ, Shivji S, Ginsberg J. Propylthiouracil-induced agranulocytosis: An unusual presentation and a possible mechanism. Am J Med 1988;85:725-727.
  10. Cooper DS, Ladenson PW. Thyroid Gland. In: Gardner D, Shoback D, eds. Greenspan's Basic and Clinical Endocrinology, (9th ed). (LANGE Clinical Medicine) McGraw-Hill; 2011.
  11. DeGroot LJ, Pacini F. Thyroid Nodules. In: De Groot LJ, Beck-Peccoz P,Chrousos G, Dungan K, Grossman A, Hershman JM, Koch C, McLachlan R,New M, Rebar R, Singer F, Vinik A, Weickert MO, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc; 2012:1-62.