Journals / Turkish Journal of Endocrinology and Metabolism / 2016 / Cilt: 20 - Sayı: 2

Maternal Propiltiyourasil Dozunun Azaltılması ile Kaybolan Fetal Guatr

Fetal Goiter was Resolved with Decreasing Maternal Propylthiouracil Dose

Pages
66–68
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It can be spontaneously resolved by decreasing the maternal dose of PTU.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:We report a case of fetal goiter diagnosed by detailed ultrasonography.
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Key Findings & Data:A 33-year-old woman at twenty weeks of gestation was referred to our hospital for detailed ultrasonography.
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Conclusion & Impact:It can be spontaneously resolved by decreasing the maternal dose of PTU.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

We report a case of fetal goiter diagnosed by detailed ultrasonography. A 33-year-old woman at twenty weeks of gestation was referred to our hospital for detailed ultrasonography. A fetal goiter was identified. She was receiving propylthiouracil (PTU) 100 mg daily for Graves' disease. Amniocentesis was performed and fetal thyroid function was evaluated as normal. Her recent thyroid function tests were normal, but antithyroid antibodies were positive. The dose of PTU was reduced to 50 mg. However, at twenty six weeks of gestation, maternal thyroid-related autoantibodies became undetectable. A fetal magnetic resonance imaging demonstrated a slight shrinkage of the fetal goiter at 30 weeks. The fetus was delivered vaginally. Thyroid function tests of the neonate were normal, and neonatal goiter was nonpalpable. Fetal goiter is a rare disease. It can be spontaneously resolved by decreasing the maternal dose of PTU.

Özet

Detaylı ultrason esnasında saptanan fetal guatr olgusunun literatür eşliğinde tartışılması. Anomali taraması için yirminci gebelik haftasında kliniğimize yönlendirilen 33 yaşındaki gebeye yapılan sonografide fetal guatr saptandı. Gebe Graves hastalığı için günlük 100 mg propiltiyourasil (PTU) almaktaydı. Gebenin tiroid fonksiyonları normaldi fakat tiroid otoantikorları pozitifti. Gebeye amniosentez yapıldı ve fetal tiroid fonksiyonları normal olarak saptandı. PTU dozu 50 mg'ye düşürüldü. Yirmi altıncı gebelik haftasında maternal kanda tiroid otoantikorları kayboldu. Otuzuncu gebelik haftasında gerçekleştirilen fetal manyetik rezonans görüntülemesinde fetal guatrın ihmal edilecek düzeyde küçüldüğü görüldü. Doğum sonrası fetüsün tiroid fonksiyonlarının normal olduğu ve guatrının kaybolduğu izlendi. Fetal guatr oldukça nadir bir hastalıktır. Annenin gebelikte kullandığı PTU dozunun düşürülmesiyle spontan olarak kaybolabilmektedir.

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Cite This Article

Yavuz, A., AKKURT, M. Ö., TATAR, B., KARAKOÇ, G., YALÇIN, Y. (2016). Maternal Propiltiyourasil Dozunun Azaltılması ile Kaybolan Fetal Guatr. Turkish Journal of Endocrinology and Metabolism, Cilt: 20 - Sayı: 2, 66–68. https://ajindex.com/articles/370843

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References (10)

  1. Corral E, Reascos M, Preiss Y, Rompel SM, Sepulveda W. Treatment of fetal goitrous hypothyroidism: value of direct intramuscular L-thyroxine therapy. Prenat Diagn 2010;30:899-901.
  2. Rosenfeld H, Ornoy A, Shechtman S, Diav-Citrin O. Pregnancy outcome, thyroid dysfunction and fetal goitre after in utero exposure to propylthiouracil: a controlled cohort study. Br J Clin Pharmacol 2009;68:609-617.
  3. Miyata I, Abe-Gotyo N, Tajima A, Yoshikawa H, Teramoto S, Seo M, Kanno K, Sugiura K, Tanaka T, Eto Y. Successful intrauterine therapy for fetal goitrous hypothyroidism during late gestation. Endocr J 2007;54:813-817.
  4. Corbacioglu Esmer A, Gul A, Dagdeviren H, Turan Bakirci I, Sahin O. Intrauterine diagnosis and treatment of fetal goitrous hypothyroidism. J Obstet Gynaecol Res 2013;39: 720-723.
  5. Perrotin F, Sembely-Taveau C, Haddad G, Lyonnais C, Lansac J, Body G. Prenatal diagnosis and early in utero management of fetal dyshormonogenetic goiter. Eur J Obstet Gynecol Reprod Biol 2001;94:309- 314. Göktolga U, Karaşahin KE, Gezginç K, Fidan U, Ergün A, Başer I. Intrauterine fetal goiter: Diagnosis and management. Taiwan J Obstet Gynecol 2008;47:87-90.
  6. Weiner S, Scharf JI, Bolognese RJ, Librizzi RJ. Antenatal diagnosis and treatment of a fetal goiter. J Reprod Med 1980;24:39-42.
  7. Lembet A, Eroglu D, Kinik ST, Gurakan B, Kuscu E. Non-invasive management of fetal goiter during maternal treatment of hyperthyroidism in Graves' disease. Fetal Diagn Ther 2005;20:254-257.
  8. Polak M, Le Gac I, Vuillard E, Guibourdenche J, Leger J, Toubert ME, Madec AM, Oury JF, Czernichow P, Luton D. Fetal and neonatal thyroid function in relation to maternal Graves' disease. Best Pract Res Clin Endocrinol Metab 2004;18:289-302.
  9. Hashimoto H, Hashimoto K, Suehara N. Successful in utero treatment of fetal goitrous hypothyroidism: case report and review of the literature. Fetal Diagn Ther 2006;21:360-365.
  10. Van Loon AJ, Derksen JT, Bos AF, Rouwé CW. In utero diagnosis and treatment of fetal goitrous hypothyroidism, caused by maternal use of propylthiouracil. Prenat Diagn 1995;7:599-604.