Cyclin-D1 protooncogen expression in prostate cancer

Objective & Hypothesis:Cyclin D1, a cell cycle regulator essential for G1 phase progression, has been implicated in the pathogenesis of certain cancers.

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Key Findings & Data:In this study, 30 prostate cancer and 25 benign prostate tissues were studied for cyclin D1 expression using an immunohistochemical technique.

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Conclusion & Impact:Further studies are needed to confirm this suggestion.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Gen ekspresyonu regülasyonu · neoplastik · Proto-onkogen proteinleri

Abstract

Cyclin D1, a cell cycle regulator essential for G1 phase progression, has been implicated in the pathogenesis of certain cancers. High levels of these proteins have been reported in certain human malignancies and have been implicated in aberrant cell division and dysregulated tumor growth. In this study, 30 prostate cancer and 25 benign prostate tissues were studied for cyclin D1 expression using an immunohistochemical technique. All of the primary prostate cancer samples revealed regions of moderate to strongly positive nuclear staining for cyclin D1, however there was no nuclear staining in the benign prostate tissue except weak staining in the stroma. There was a positive correlation between Gleason grade and staining intensity for cyclin D1. The increased expression of cyclin D1 in prostate cancer samples suggests that further studies on the expression of this gene and related genes may be of interest in understanding the pathogenesis of prostate cancer. The positive correlation between Gleason grade and protein expression may be used as a prognostic marker in prostate cancer. Further studies are needed to confirm this suggestion.

Özet

Cyclin D1, a cell cycle regulator essential for G1 phase progression, has been implicated in the pathogenesis of certain cancers. High levels of these proteins have been reported in certain human malignancies and have been implicated in aberrant cell division and dysregulated tumor growth. In this study, 30 prostate cancer and 25 benign prostate tissues were studied for cyclin D1 expression using an immunohistochemical technique. All of the primary prostate cancer samples revealed regions of moderate to strongly positive nuclear staining for cyclin D1, however there was no nuclear staining in the benign prostate tissue except weak staining in the stroma. There was a positive correlation between Gleason grade and staining intensity for cyclin D1. The increased expression of cyclin D1 in prostate cancer samples suggests that further studies on the expression of this gene and related genes may be of interest in understanding the pathogenesis of prostate cancer. The positive correlation between Gleason grade and protein expression may be used as a prognostic marker in prostate cancer. Further studies are needed to confirm this suggestion.

Keywords

Gen ekspresyonu regülasyonu neoplastik Proto-onkogen proteinleri G1 fazı Prostat neoplazmları İmmünohistokimya Proto-onkogenler Gen ekspresyonu Siklin D1 Hücre siklusu proteinleri Hücre siklusu Gene Expression Regulation Neoplastic Proto-Oncogene Proteins G1 Phase Prostatic Neoplasms Immunohistochemistry Proto-Oncogenes Gene Expression Cyclin D1 Cell Cycle Proteins Cell Cycle

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Cite This Article

ÖZBEK, E., MIZRAK, B., ÖZBEK, M., BÜYÜKBERBER, S., DAVARCI, M. (2000). Cyclin-D1 protooncogen expression in prostate cancer. Turkish Journal of Cancer, Cilt: 30 - Sayı: 1, 15–23. https://ajindex.com/articles/368510

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