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Journals / Toraks Dergisi / 2005 / Cilt: 6 - Sayı: 2

Value of bronchoscopic biopsy and transthoracic fine needle aspiration in determining the tumor type in lung cancer

Akciğer kanserinde tümör tipinin saptanmasında bronkoskopik biyopsi ve transtorasik ince iğne aspirasyonunun değeri

Sinem GÜNGÖR
Ebru DAMADOĞLU
Aysun AYBATLI
Günay CAN
Adnan YILMAZ
Esen AKKAYA
Ali ATASALİHİ
Pages
122–126
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The overall concordance rate was 89.8% (Kappa, 0.63) in group A.

📌 3 Key Takeaways

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Objective & Hypothesis:The purpose of this retrospective study was to evaluate the diagnostic accuracy of bronchoscopic biopsy and transthoracic fine needle aspiration (TFNA) specimens in establishing the specific cell type in primary lung cancer and to study the influence of several factors on this accuracy.
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Key Findings & Data:The study included 177 patients with lung cancer who underwent thoracotomy between January 2001 and June 2002.
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Conclusion & Impact:The overall concordance rate was 89.8% (Kappa, 0.63) in group A.
🔬Design:Research Article
📍Scope:2001 Verileri
⚙️Variables:Adenokarsinom · Akciğer neoplazmları · Neoplazmların histolojik tipleri

Abstract

The purpose of this retrospective study was to evaluate the diagnostic accuracy of bronchoscopic biopsy and transthoracic fine needle aspiration (TFNA) specimens in establishing the specific cell type in primary lung cancer and to study the influence of several factors on this accuracy. The study included 177 patients with lung cancer who underwent thoracotomy between January 2001 and June 2002. The initial diagnostic method was bronchoscopic biopsy in 118 patients (group A) and TFNA in 59 patients (group B). The overall concordance rate was 89.8% (Kappa, 0.63) in group A. The concordance rate was 97% in cases with squamous cell carcinoma and 61.5 % in cases with adenocarcinoma (p=0.02). Cell type agreement rate was higher in central lesions than peripheral lesions in group A (p=0.006). In group B, the overall concordance was 74.6% (Kappa, 0.57). The concordance rate was 70.6% in cases with squamous cell carcinoma and 83.3% in cases with adenocarcinoma (p>0.05). Cell type agreement rate was lower in poorly differentiated tumors than in well-differentiated tumors (p=0.043, OR=10.43) in group B. In conclusion, cell type discordance is a more common problem in TFNA specimens than in bronchoscopic biopsy specimens in our series. Several factors such as tumor localization and degree of cell differentiation can affect cell agreement.

Özet

Bu geriye dönük çalışmanın amacı, primer akciğer kanserinde hücre tipinin saptanmasında bronkoskopik biyopsi ve transtorasik ince iğne aspirasyonu (TTİİA) örneklerinin değerini ve çeşitli faktörlerin etkisini araştırmaktı. Ocak 2001-Haziran 2002 tarihleri arasında torakotomi uygulanan akciğer kanserli 177 olgu çalışmaya alındı. Tanı yöntemi 118 olguda bronkoskopik biyopsi (grup A), 59 olguda TTİİA (grup B) idi. Grup A’da uyum oranı %89.8 (Kappa değeri, 0.63) olup, bu değer epidermoid karsinom için %97, adenokarsinom için %61.5 idi (p=0.02). Hücre uyumu santral lezyonlarda periferik lezyonlardakinden daha yüksek bulundu (p=0.006). Grup B’de, uyum oranı %74.6 (Kappa değeri, 0.57) idi. Uyum oranı, epidermoid karsinom için %70.6, adenokarsinom için %83.3 olarak bulundu (p>0.05). Hücre uyumu, bu grupta kötü farklılaşmış tümörlerde iyi farklılaşmış tümörlerdekine göre daha düşüktü (p=0.043, OR=10.43). Sonuç olarak, bizim serimizde, hücre uyumsuzluğu TTİİA için daha yaygın bir sorundur. Tümör lokalizasyonu ve tümör farklılaşma derecesi gibi çeşitli faktörler hücre uyumunu etkileyebilir.

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Cite This Article

GÜNGÖR, S., DAMADOĞLU, E., AYBATLI, A., CAN, G., YILMAZ, A., AKKAYA, E., ATASALİHİ, A. (2005). Value of bronchoscopic biopsy and transthoracic fine needle aspiration in determining the tumor type in lung cancer. Toraks Dergisi, Cilt: 6 - Sayı: 2, 122–126. https://ajindex.com/articles/368082

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