Journals / Toraks Dergisi / 2006 / Cilt: 7 - Sayı: 2

Assessment of tobacco smoke exposure in fetus with cord blood cotinine measurements

Fetustaki sigara dumanı maruziyetinin kord kanı kotinin düzeyi ile değerlendirilmesi

Pages
115–119
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

These results suggested that when the pregnant exposed to active or passive cigarette smoke, fetus also exposed to smoke at intrauterine period.

📌 3 Key Takeaways

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Objective & Hypothesis:The aim of this study was to determine the cotinine levels in the cord blood of infants who were exposed to cigarette smoke in the prenatal period and to emphasize the effects of passive exposure.
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Key Findings & Data:Just before delivery, 107 pregnant women were included in the study.
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Conclusion & Impact:These results suggested that when the pregnant exposed to active or passive cigarette smoke, fetus also exposed to smoke at intrauterine period.
🔬Design:Survey & Empirical Study
📍Scope:Comprehensive Sample
⚙️Variables:Kemiluminesan ölçümler · Fetal kan · Kotinin

Abstract

The aim of this study was to determine the cotinine levels in the cord blood of infants who were exposed to cigarette smoke in the prenatal period and to emphasize the effects of passive exposure. Just before delivery, 107 pregnant women were included in the study. They were included in a questionnaire about their smoking habits and demographical status. After the blood was drawn from mother and the cord just after the baby delivered, serum cotinine levels were measured. Besides the height, weight and gestational age of the infants were recorded. According to the self reports, cases divided into three groups as follows; active smokers (n=35), passive smokers (n=36), group of no exposure (control group) (n=36). When compared with the control group the cotinine levels were significantly higher either in the mother or the cord blood of active and passive smokers (p<0.05). The cotinine levels in the mother and cord blood in active smokers were also found to be significantly higher than the passive smokers (p<0.05), and a strong correlation has been determined between the mother&#8217;s and the cord blood cotinine levels. Besides there were an increased linear correlation between the cotinine levels of mother and cord blood levels related to the number of exposed or smoked cigarette (p<0.05). No significant difference has been determined with respect to the height, weight and gestational ages of the infants between three groups (p>0.05). These results suggested that when the pregnant exposed to active or passive cigarette smoke, fetus also exposed to smoke at intrauterine period. But in order to find out the harmful effects of exposure more detailed and long-term studies are needed.

Özet

Prenatal dönemde sigaraya maruz kalan bebeklerin kord kanı kotinin düzeylerinin belirlenmesi ve pasif maruziyetin etkilerinin gösterilmesi amacıyla; doğum yapmak üzere doğumhaneye alınan 107 gebe çalışmaya alınmıştır. Tüm gebelere sigara alışkanlıklarını ve demografik özelliklerini sorgulayan anket uygulanmıştır. Daha sonra annelerden 5cc venöz kan, doğum eylemi gerçekleştikten hemen sonra da 5cc kord kanı alınarak bu örneklerde kotinin düzeyleri çalışılmıştır. Ayrıca bebeklerin ağırlıkları, boyları ve gestasyonel yaşları kaydedilmiştir. Gebeler, ankete verdikleri yanıtlara göre üç gruba ayrılmıştır; aktif içici (n=35), pasif içici (n=36), kontrol grubu (n=36). Aktif içiciler ve pasif içicilerin anne ve bebek kord kanı kotinin seviyeleri, kontrol grubuna göre istatistiksel olarak anlamlı derecede yüksek bulunmuştur (p 0.05). Bu sonuçlar gebenin sigara dumanına maruz kalması durumunda fetusun da bu dumana maruz kaldığını göstermiştir. Ancak fetustaki bu maruziyetin ne gibi zararlı etkiler yaptığını göstermek için daha ayrıntılı ve uzun süreli araştırmalar yapılması gereklidir.

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Cite This Article

BOYACI, H., BÜYÜKGÖZE, B., BAŞYİĞİT, İ., YILDIZ, F., ILGAZLI, A., DUMAN, C. (2006). Assessment of tobacco smoke exposure in fetus with cord blood cotinine measurements. Toraks Dergisi, Cilt: 7 - Sayı: 2, 115–119. https://ajindex.com/articles/367938

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