AI Summary & Key Takeaways
AI InsightDuring CT examination of the thorax of 41 patients showed that 16 patients had pneumonia, 5 had atelectasis, 3 had bronchiectasis, 3 had obliterative bronchiolitis, 1 had bronchogenic cysts, 1 had interstitial lung disease; 12 children revealed no pathology.
📌 3 Key Takeaways
Abstract
In this study, 110 children between 1 month and 3 years of age, who had experienced 3 or more wheezing episodes were investigated; the etiology and risk factors were examined. Also, etiology and risk factor profiles are evaluated on the basis of related literature. For early childhood wheezing, the risk factors determined were; male sex, young maternal age, maternal asthma, dampness at home, sibling history of asthma or wheezing attacks, and intermediate social status. Studies regarding etiology showed, 7 patients (6%) to have partial Ig A deficiency, 1 patient (2%) IgG2 subclass deficiency and 1 patient (2%) IgG3 subclass deficiency. Eight children had high IgE (7%) levels. Purified protein derivative (PPD) skin testing was performed in all cases and only one had a positive skin reaction to PPD. Acid-fast staining was performed in 25 children; positive results were found in 4. Sweat chloride testing was performed in 69 children and 14 had positive results. By mutation identification, 2 had a diagnosis of cystic fibrosis. Gastric scintigraphy was performed in 43 (39%). Of these, 24 (56%) had positive results for gastroesophageal reflux. During CT examination of the thorax of 41 patients showed that 16 patients had pneumonia, 5 had atelectasis, 3 had bronchiectasis, 3 had obliterative bronchiolitis, 1 had bronchogenic cysts, 1 had interstitial lung disease; 12 children revealed no pathology.
Özet
Bu çalışmada, üç ve üçün üstünde hışıltı atağı geçiren, 1 ay- 3 yaş arası 110 olgu etiyoloji ve risk faktörleri açısından incelendi. Hem risk faktörleri hem de etiyolojik nedenlere ilişkin elde edilen veriler literatür eşliğinde değerlendirildi. Erken hışıltılı çocuklarda risk faktörü olarak erkek cinsiyet, anne yaşının genç olması, annede astma öyküsü, kardeşte hışıltı atağı, evin nemli olması belirlendi. Ayrıca orta düzeyde sosyoekonomik durum da risk faktörü olarak bulundu. Etiyolojik açıdan yapılan tetkikler ile 7 olguda (%6) parsiyel IgA eksikliği, 1 olguda IgG2 (%2) ve 1 olguda IgG3 (%2) eksikliği saptandı. 8 olguda IgE (%7) düzeyi normalin üstünde bulundu. Tüm olgulara uygulanan PPD testi yorumuna göre 1 olguda pozitif bulundu. 25 olguya yapılan açlık mide suyunda asidorezistan bakteri bakısı 4 olguda pozitifti. Ter testi yapılan 69 hastadan 14’ünde kistik fibrozis saptandı, 2’sinin mutasyon analizi sonuçları ile tanıları kesinleşti. 43 olguya (% 39) gastroözefagial reflü sintigrafisi yapıldı. Bunların 24’ ünde (%56) sintigrafik olarak reflü pozitif saptandı. Hastaların 41’ine (% 37) toraks tomografisi çekildi; 16’sında pnömoni, 5’inde atelektazi, 3’ünde bronşiolitis obliterans, 3’ünde bronşektazi, 1’inde bronkojenik kist, 1’inde intersitisyel akciğer hastalığı saptanırken, 12’si normal olarak değerlendirildi.