Journals / Toplum ve Hekim / 2016 / Cilt: 31 - Sayı: 4

Evolution of Aging and Medicine

YAŞLANMANIN EVRİMİ VE TIP

Pages
314–316
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

If we can uncover new mechanisms for longevity by artificial selection in model organisms, we can use some of the suitable ones for rejuvenation medicine.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aging is one of the very complex biological processes.
📊
Key Findings & Data:It also increases the risk of dying from any factor that is generally not very harmful for young people.
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Conclusion & Impact:If we can uncover new mechanisms for longevity by artificial selection in model organisms, we can use some of the suitable ones for rejuvenation medicine.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aging is one of the very complex biological processes. Therefore it will likely be a very diff icult process, and take a long time to uncover its mechanisms. From the viewpoint of medicine, aging can also be accepted -at least for pragmatic reasons- as a disease that aff ects everybody. It also increases the risk of dying from any factor that is generally not very harmful for young people. Since there seems no advantage for natural selection of the mechanisms that cause aging, it is likely a side eff ect of selected properties. If we can uncover new mechanisms for longevity by artificial selection in model organisms, we can use some of the suitable ones for rejuvenation medicine.

Özet

Yaşlanma, en karmaşık biyolojik süreçlerden biridir. Bu nedenle yaşlanmanın mekanizmalarını çözmek muhtemelen çok zor ve zaman alıcı bir süreç olacaktır. Tıbbi bir bakış açısıyla yaşlanma, -pragmatik gerekçelerle bile olsa- herkesi etkileyen bir hastalık olarak kabul edilebilir. Yaşlanmak, gençlerde çok zararlı olmayan bazı faktörlere bağlı ölüm riskini de artırır. Yaşlanmaya yol açan mekanizmalarda doğal seçilimin bir avantajı görünmediği için, yaşlanma seçilmiş özelliklerin bir yan etkisi olabilir. Model organizmalarda yapay seçilimin uzun yaşamı sağlayan yeni mekanizmalar keşfedebilirsek, bunların bazı uygun olanlarını gençleştirici tıpta da kullanabiliriz.

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Cite This Article

OLGUN, A. (2016). Evolution of Aging and Medicine. Toplum ve Hekim, Cilt: 31 - Sayı: 4, 314–316. https://ajindex.com/articles/367802

References (7)

  1. Abele D., Strahl J., Brey T., Philipp E.E. (2008) Imperceptible senescence: ageing in the ocean quahog Arctica islandica. Free Radic Res. 2008 May: 42(5):474-80.
  2. Dragosits, M., Mattanovich, D. (2013) Adaptive laboratory evolution -- principles and applications for biotechnology. Mic- rob Cell Fact. 2013 Jul 1:12:64. Hoff mann, P.M. (2012) Life's Ratchet: How Molecular Machi- nes Extract Order from Chaos, Basic Books, New York, 2012.
  3. Kirkwood, T.B.L. (1992) Comparative life spans of species: why do species have the life spans they do?, American Journal of Cli- nical Nutrition, 55: 1191S-1195S. Lanner, R.M. (2001) Connor KF. Does bristlecone pine senesce? Exp Gerontol. Apr: 36(4-6):675-85.
  4. Lithgow, G. J., Kirkwood, T. B. L. (1996)
  5. Mechanisms and evo- lution of aging, Science, 273: 80. Ricklefs, R. E.,Finch, C. E. (1995) Aging: a natural history, New York, ScientificAmerican Library, 3-187.
  6. Riehle, M.M., Bennett, A.F., Lenski, R.E., (2003) Long AD.Evolutionary changes in heat-inducible gene expression in lines of Escherichia coli adapted to high temperature. Physiol Genomics. Jun 24:14(1):47-58.
  7. Williams, G.C. (1957) "Pleiotropy, natural selection, and the evolution of senescence". Evolution, 11: 398-411.