Journals / Toplum ve Hekim / 2016 / Cilt: 31 - Sayı: 5

Model Organisms and Common Evolutionary Origins: Drosophila Parkinson Model

EVRİMSEL ORTAKLIKLAR TEMELİNDE MODEL ORGANİZMALAR: DROSOPHILA MODELİ VE PARKİNSON HASTALIĞI

Pages
359–366
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Work on the Parkinson genetics with the fruit fl y Drosophila melanogaster continues to provide exquisite examples of model organism use in disease.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Model organism use emphasizes on the shared evolutionary history among organisms and has paved the ways that led to many important discoveries.
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Key Findings & Data:Model organism use emphasizes on the shared evolutionary history among organisms and has paved the ways that led to many important discoveries.
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Conclusion & Impact:Work on the Parkinson genetics with the fruit fl y Drosophila melanogaster continues to provide exquisite examples of model organism use in disease.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Model organism use emphasizes on the shared evolutionary history among organisms and has paved the ways that led to many important discoveries. Work on the Parkinson genetics with the fruit fl y Drosophila melanogaster continues to provide exquisite examples of model organism use in disease.

Özet

Parkinson hastalığı hakkında, evrimsel ortaklığı simgeleyen model organizmaların kullanılmasıyla önemli bilgiler elde edilmektedir. Meyve sineği Drosophila melanogaster ile yapılan Parkinson genetiği çalışmaları model organizma kullanımının başarılı sonuçlarını gösteren temel bir örnektir.

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Cite This Article

DÜZGÜN, Ö. (2016). Model Organisms and Common Evolutionary Origins: Drosophila Parkinson Model. Toplum ve Hekim, Cilt: 31 - Sayı: 5, 359–366. https://ajindex.com/articles/367467

References (13)

  1. A ttaix, D., ve ark. (2005).Th e ubiquitin-proteasome system and skeletal muscle wasting., Essays in Biochemistry Journal Impact & Description., 41: 173-86.
  2. Bedard, P.J. (2001) Th e Pros and Cons of Treating Parkinson's Disease, Can. J. C., 13, (7): 77-88.
  3. Clark, I.E., ve ark. (2006).Drosophila pink1 is required for mi- tochondrial function and interacts genetically with parkin., Na- ture, 441 (7097): 1162- 66. Corti, O., Lesage, S., Brice, A. (2011) What Genetics Tells us About the Causes and Mechanisms of Parkinson's Disease, Physiological Reviews, 91: 1161-1218.
  4. De. Lau, L. M. L., Breteler M.M.B.( 2006).Epidemiology of Parkinson's disease.,Th e Lancet Neurology., 5 (6): 525-35.
  5. Di Monte, D.A. (2003) Th e environment and Parkinson's disea- se: Is the nigrostriatal system preferentially targeted by neuroto- xins?, Lancet Neurology, (2): 531-538.
  6. Düzgün, Ö., (2016). Drosophila melanogaster' De parkin Geni İle Etkileşen Genomik Elementlerin Negatif Jeotaksis İfadesi İle Saptanması, Yüksek Lisans Tezi, Hacettepe Üniversitesi Fen Bi- limleri Enstitüsü, Ankara.
  7. Elbaz, A., Moisan, F. (2008), Update in the epidemiology of Parkinson's disease., Current Opinion in Neurology., (21): 454- Feany, M. B., Bender W.W.,A. (2000).Drosophila model ofParkinson's disease. Nature, 404 (6776): 394-8.
  8. Forno, L. S. (1996).Neuropathology of Parkinson's disease, J. Journal of Neuropathology & Experimental Neurology, 55 (3): -72. Gibson, G. (2015). A Primer of Human Genetics, 1st ed. Si- nauer Associates Goetz, C.G., (2011)The history of Parkinson's disease: Early clinical descriptions and neurological therapies, Cold Spring Harbor Perspectives in Medicine., vol. 1. Greene, J.C., ve ark. (2003).Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mu- tants., Proceedings of the National Academy of Sciences, 100, (7): 4078-83.
  9. Hill-Burns, E.M., ve ark. (2014)., Identification of a novel Parkinson's disease locus via stratified genome-wide associa- tion study., BMC Genomics, 15 (1): 118. Hoang, Q.Q. (2014).
  10. Pathway for Parkinson disease, Proce- edings of the National Academy of Sciences 111 (7): 2402-3.
  11. Jaiswal, M., ve ark. (2012).Probing mechanisms that under- lie human neurodegenerative diseases in Drosophila., Annu- al Review of Genetics., 46: 371-96.
  12. Jones, M. A., Grotewiel, M. (2011).Drosophila as a model for age-related impairment in locomotor and other behaviors,Experimental Gerontology, 46 (5) 320-25.
  13. Kitada, T., ve ark. (1998).Mutations in the parkin