Journals / Şişli Etfal Hastanesi Tıp Bülteni / 2016 / Cilt: 50 - Sayı: 1

Ağır preeklamptik hastalarda kardiak troponin I düzeyi ve magnezyum sülfat tedavisinin kardiak troponin I düzeyine etkisi

Cardiac Troponin I Levels in Patients with Severe Preeclampsia and Effect of Magnesium Sulfate Treatment on Cardiac Troponin I Levels

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26–32
DOI
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In addition, it was determined that magnesium sulfate treatment reduced troponin I levels and did not cause myocardial injury

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Objective & Hypothesis:Cardiac troponin I levels in patients with severe preeclampsia and effect of magnesium sulfate treatment on cardiac troponin I levelsObjective: It was aimed to investigate minor myocardial injury in preeclampsia by comparing troponin I levels in pregnant women with preeclampsia and normal pregnant women, and to examine the effect of magnesium sulfate treatment on cardiac troponin I levels.
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Key Findings & Data:Material and Method: The study included two groups as one preeclemptic group consisting of 25 pregnant women with preeclampsia (group 1) and a control group consisting of 25 pregnant women who do not have any medical or obstetric problem.
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Conclusion & Impact:In addition, it was determined that magnesium sulfate treatment reduced troponin I levels and did not cause myocardial injury
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Cardiac troponin I levels in patients with severe preeclampsia and effect of magnesium sulfate treatment on cardiac troponin I levelsObjective: It was aimed to investigate minor myocardial injury in preeclampsia by comparing troponin I levels in pregnant women with preeclampsia and normal pregnant women, and to examine the effect of magnesium sulfate treatment on cardiac troponin I levels. Material and Method: The study included two groups as one preeclemptic group consisting of 25 pregnant women with preeclampsia (group 1) and a control group consisting of 25 pregnant women who do not have any medical or obstetric problem. Mean serum cardiac troponin I levels measured before and after magnesium sulfate treatment in pregnant women with preeclampsia were compared to troponin I levels in healthy pregnant women.Results: There was no statistically significant difference between the two groups regarding their demographical properties (p>0.05). As for the comparison of mean cardiac troponin I levels between groups, there was marked and statistically significant difference between Group I (0.0944±0.044 ng/mL) and Group II (0.006±0.002 ng/mL) (p<0.05). In patients with preeclampsia (Group I), troponin I levels were higher before magnesium sulfate treatment (0.094±0.044 ng/mL) compared to levels measured after treatment (0.0048±0.0017 ng/mL), and the difference was statistically significant (p<0.05). Conclusion: In our study, levels of troponin I, which is the best known indicator of minor myocardial injury, was higher in pregnant women with severe preeclampsia compared to the control group, suggesting myocardial injury related to hypertensive diseases in pregnancy. In addition, it was determined that magnesium sulfate treatment reduced troponin I levels and did not cause myocardial injury

Özet

Amaç: Preeklamptik gebeliklerdeki troponin I değerleri normal gebelerdeki değerlerle karşılaştırılarak preeklampsideki minör myokardiyal hasar araştırmak ve magnezyum sülfat tedavisinin kardiak troponin I düzeyine etkisini incelemek amaçlanmıştır. Gereç ve Yöntem: Çalışmaya; 25 gebeden oluşan preeklamptik grup (grup 1) ve herhangi bir medikal ve obstetrik sorunu olmayan 25 gebeden oluşan kontrol grubu (grup2) olmak üzere iki grup dahil edildi. Preeklamptik gebelere uygulanan magnezyum sülfat tedavisinden öncesinde ve bitiminde troponin I düzeyleri ile saglıklı gebelerdeki troponın I düzeyleri ölçüldü. Peeklampsi hastalarında magnezyum sülfat tedavisi öncesive sonrası bakılan ortalama serum kardiak troponin I değerleri ile saglıklı gebelerdeki troponin I düzeyleri karsılaştırıldı.Bulgular: İki grup arasında, demografik özellikler açısından istatistiksel olarak anlamlı fark yoktu (p>0.05). Gruplar arasında ortalama kardiak troponin I değerleri karşılaştırıldığında Grup I'de (0.0944±0.044), Grup II'ye (0.006±0.002) kıyasla yüksek düzeyde ve istatistiksel olarak anlamlı fark olduğu saptandı (p<0.05). Peeklampsi hastalarında (Grup I), magnezyum tedavisi öncesi kardiak troponin I değerinin (0.094±0.044), tedavi sonrası değerlerden (0.0048±0.0017) yüksek olduğu ve istatistiksel olarak anlamlı fark olduğu tespit edildi (p<0.05) Sonuç: Çalışmamızda, minör miyokardial hasarın bilinen en iyi göstergesi olan troponin I'nın preeklamptik gebelerde kontrol grubuna göre yüksek bulunması, gebelikte hipertansif hastalıklarla ilişkili miyokardial hasarı düşündürmektedir. Ayrıca magnezyum sülfat tedavisinin, troponin I düzeyini azalttığı ve miyokardial hasara neden olmadığı sonucuna varılmıştır

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Cite This Article

ÇOT, Ö., KUMBASAR, S., ŞIK, B. A., DEMİR, M., SEVER, E., KAYAALTİ, E. S. (2016). Ağır preeklamptik hastalarda kardiak troponin I düzeyi ve magnezyum sülfat tedavisinin kardiak troponin I düzeyine etkisi. Şişli Etfal Hastanesi Tıp Bülteni, Cilt: 50 - Sayı: 1, 26–32. https://ajindex.com/articles/363774

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