AI Summary & Key Takeaways
AI InsightWith this purpose, neutrophil-lymphocyte ratio might be considered as an easily accessed, available and cost-effective laboratory marker
📌 3 Key Takeaways
Abstract
Objective: Psoriasis is a chronic, inflammatory, systemic disease. Psoriasis Area and Severity Index (PASI) is used to evaluate the disease activity and response to therapy in psoriasis patients. However, more objective laboratory tools should be developed beside PASI. Neutrophil-lymphocyte ratio and mean platelet volume are inflammatory biomarkers that are known to be evaluated in various inflammatory diseases. The purpose of this study was to analyse the levels of neutrophil-lymphocyte ratio and mean platelet volume in psoriasis patients and to investigate the relationship between these biomarkers and the disease activity.Materials and Methods: Fourty-nine patients with chronic plaque psoriasis and 47 controls were included in the study. Neutrophil-lymphocyte ratio and mean platelet volume values of two groups were retrospectively evaluated.Results: Neutrophil-lymphocyte ratio levels were significantly higher in patients with psoriasis than in healthy controls (p<0.001). The levels of mean platelet volume did not show statistically significant difference between psoriasis patients and controls (p=0.061). When psoriasis patients were evaluated according to disease severity, no correlation was found between the disease activity and neutrophillymphocyte ratio and mean platelet volume values (p>0.05). Conclusion: In the recent studies, it has been mentioned that the neutrophil-lymphocyte ratio and mean platelet volume have prognostic importance for cardiovascular diseases. Assessment and management of the inflammatory status in psoriasis patients is important to prevent the comorbidities such as cardiovascular diseases. With this purpose, neutrophil-lymphocyte ratio might be considered as an easily accessed, available and cost-effective laboratory marker
Özet
Amaç: Psoriazis, kronik, inflamatuar, sistemik bir hastalıktır. Psoriaziste hastalık şiddetini ve tedaviye yanıtı değerlendirmede Psoriazis Alan ve Şiddet İndeksinin (PAŞİ) yanısıra daha objektif laboratuvar araçlarına ihtiyaç vardır. Nötrofil lenfosit oranı ve ortalama trombosit hacmi çeşitli inflamatuar hastalıklarda arttığı bilinen inflamatuar belirteçlerdir. Bu çalışmada amacımız psoriazisli hastalarda nötrofil lenfosit oranı ve ortalama trombosit hacmi değerlerini incelemek ve hastalık şiddetiyle ilişkisini değerlendirmektir.Gereç ve Yöntemler: Kırk dokuz kronik plak tip psoriazisli hasta ve 47 kontrolün nötrofil lenfosit oranı ve ortalama trombosit hacmi retrospektif olarak değerlendirildi.Bulgular: Psoriazisli hastalarda nötrofil lenfosit oranı kontrollerden anlamlı olarak yüksek bulundu (p 0.05).Sonuç: Son yıllardaki çalışmalarda, kardiyovasküler hastalıklarda nötrofil lenfosit oranı ve ortalama trombosit hacminin prognostik önemi olduğu üzerinde durulmaktadır. Psoriazisli hastalarda sistemik inflamasyonun belirlenmesi ve tedavisi kardiyovasküler hastalıklar gibi eşlik edebilecek komorbiditelerin de azaltılabilmesi bakımından önemlidir. Bu amaçla nötrofil lenfosit oranı kullanışlı, kolay ulaşılabilir ve ucuz bir laboratuvar parametre olabilir