Skin metastases of internal malignancies should be considered in the differential diagnosis in cases with atypical nodules on the skin.
📌 3 Key Takeaways
🎯
Objective & Hypothesis:Cutaneous metastases represent 2% of all metastases.
📊
Key Findings & Data:Here we report 2 previously undiagnosed patients who presented at a dermatology outpatient clinic with firm, ulcerated lesions on the skin as the first sign of breast carcinoma.
💡
Conclusion & Impact:Skin metastases of internal malignancies should be considered in the differential diagnosis in cases with atypical nodules on the skin.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Cutaneous metastases represent 2% of all metastases. Although rare in clinical practice, cutaneous metastases are important in that they indicate a poor prognosis for the disease. Cutaneous metastases are usually symptoms of advanced internal malignancies, and rarely, they may be the first clinical manifestation of an unknown internal neoplasm. Here we report 2 previously undiagnosed patients who presented at a dermatology outpatient clinic with firm, ulcerated lesions on the skin as the first sign of breast carcinoma. Skin metastases of internal malignancies should be considered in the differential diagnosis in cases with atypical nodules on the skin.
🔖
Cite This Article
CERMAN, A. A., ALTUNAY, İ. K., YALÇIN, Ö., KARABAY, E. A. (2017). Two Cases of Breast Cancer Presenting Primarily with Skin Metastasis. Southern Clinics of Istanbul Eurasia, Cilt: 28 - Sayı: 2, 151–154. https://ajindex.com/articles/313259
Alcaraz I, Cerroni L, Rütten A, Kutzner H, Requena L. Cutaneous metastases from internal malignancies: a clinicopathologic and immunohistochemical review. Am J Dermatopathol 2012;34:347–93
Tosun A, Tosun S. Cilt metastazı ile ortaya çıkan meme kanseri: İki olgu sunumu. Meme Sağlığı Dergisi 2008;4:118–21
Saeed S, Keehn CA, Morgan MB. Cutaneous metastasis: a clinical, pathological, and immunohistochemical appraisal. J Cutan Pathol 2004;31:419–30
De Giorgi V, Grazzini M, Alfaioli B, Savarese I, Corciova SA, Guerriero G, et al. Cutaneous manifestations of breast carcinoma. Dermatol Ther 2010;23:581–9
Schwartz RA. Cutaneous metastatic disease. J Am Acad Dermatol 1995;33:161–82
Vichapat V, Garmo H, Holmberg L, Fentiman IS, Tutt A, Gillett C, et al. Patterns of metastasis in women with metachronous contralateral breast cancer. Br J Cancer 2012;107:221–3
Hwang SK, Chen Z, Sun Q, Pan R, Pang MH. Cutaneous metastasis of breast cancer previously diagnosed 25 years ago. Chin Med J (Engl) 2014;127:1000
Cassarino DS, Cabral ES, Kartha RV, Swetter SM. Primary dermal melanoma: distinct immunohistochemical findings and clinical outcome compared with nodular and metastatic melanoma. Arch Dermatol 2008;144:49–56
Lookingbill DP, Spangler N, Helm KF. Cutaneous metastases in patients with metastatic carcinoma: a retrospective study of 4020 patients. J Am Acad Dermatol 1993;29:228–36
Lookingbill DP, Spangler N, Sexton FM. Skin involvement as the presenting sign of internal carcinoma. A retrospective study of 7316 cancer patients. J Am Acad Dermatol 1990;22:19–26
Bittencourt Mde J, Carvalho AH, Nascimento BA, Freitas LK, Parijós AM. Cutaneous metastasis of a breast cancer diagnosed 13 years before. An Bras Dermatol 2015;90:134–7
Zindancı İ, Can B, Zemheri E, Kavala M. Two Cases of Breast Cancer Presented with Skin Metastasis as First Signs. Türkderm 2006;40:B31–3
Oliveira GM, Zachetti DB, Barros HR, Tiengo A, Romiti N. Breast carcinoma en Cuirasse-case report. An Bras Dermatol 2013;88:608–10.