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Journals / Şişli Etfal Hastanesi Tıp Bülteni / 2004 / Cilt: 38 - Sayı: 3

Diagnostic effectiveness of ultrasonographic morphologic scoring, serum CA125 level, color Doppler sonography and peritoneal cytology for malign-benign differentiation of the adnexal mass

Adneksiyal kitlenin habis-selim ayırımında ultrasonografik morfolojik skorlama, serum CA 125 düzeyi, color Doppler sonografi ve peritoneal sitolojinin tanısal etkinliği

Meltem TEKELİOĞLU
Emin ZEYBEK
Yavuz Tahsin AYANOĞLU
Pages
64–71
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: It was found that UMS, serum CA125 level and CDS had very high sensitivity.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: To identify the diagnostic effectiveness of ultrasonographic morphologic scoring (UMS), serum CA125 level, color Doppler sonography (CDS) and peritoneal cytology for malign-benign differentiation of the adnexal mass.
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Key Findings & Data:Study design: The outcomes of UMS, CA125, CDS and peritoneal cytology of 74 patients with adnexal mass (46 preme-napausal and 28 postmenopausal) administered Taksim Training and Research Hospital, Gynecology and Obstetrics Clinic was compared with histopatologic outcomes.
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Conclusion & Impact:Results: It was found that UMS, serum CA125 level and CDS had very high sensitivity.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Menopoz · CA-125 antijen · Tanı teknik ve işlemleri

Abstract

Objectives: To identify the diagnostic effectiveness of ultrasonographic morphologic scoring (UMS), serum CA125 level, color Doppler sonography (CDS) and peritoneal cytology for malign-benign differentiation of the adnexal mass. Study design: The outcomes of UMS, CA125, CDS and peritoneal cytology of 74 patients with adnexal mass (46 preme-napausal and 28 postmenopausal) administered Taksim Training and Research Hospital, Gynecology and Obstetrics Clinic was compared with histopatologic outcomes. Diagnostic effectiveness of each method was assesed with sensitivity, specifity, negative predictive value, positive predictive value and total diagnostic value. Results: It was found that UMS, serum CA125 level and CDS had very high sensitivity. Because of lower positive predictive values with UMS and CA125, combination of these methodes with CDS gets higher the diagnostic effectiveness. Conclusions: CDS alone was found enough to identify postmenopausal adnexal malignity. Also CA125 was found very effective. UMS should combine with CA125 or CDS in this group. As a result of lower positive predictivity of CA125, CDS should add to UMS in premenopausal group. Peritoneal cytology was not defined as an effective method in this study

Özet

Amaç: Adneksiyal kitlenin habis-selim ayırımında ultrasonografik morfolojik skorlama (UMS), serum CA125 düzeyi, color Doppler sonografi (CDS) ve peritoneal sitolojinin tanısal etkinliklerini belirlemeyi amaçladık. Gereç-Yöntem: Adneksiyal kitle tanısıyla Taksim Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Kliniği'ne yatırılan, 46'sı premenopozal ve 28'i postmenopozal 74 hastanın ameliyat öncesinde yapılan UMS, CA125 düzeyi, CDS ve peritoneal sitoloji sonuçlan, ameliyat piyeslerinin histopatolojik sonuçları ile karşılaştırıldı. Bu dört yöntem için tanısal etkinlik; duyarlılık, seçicilik, negatif prediktif değer, pozitif prediktif değer ve toplam tam değerine bakılarak değerlendirildi. Bulgular: UMS, serum CA125 düzeyi ve CDS duyarlılığı ve toplanı tanı değeri çok yüksek testler olarak ortaya çıkmıştır. UMS ve serum CAJ25 düzeyi saptamasında pozitif prediktivi-te düşük olup, CDS'nin bu testlerle birlikte kullanılması güvenilirliği arttırmaktadır. Sonuç: Postmenopozal hastalarda adneksiyal maligniteyi saptamada; CDS tek başına yeterli bir yöntem olup, serum CAI25 düzeyi de çok güvenilirdir. Bu grupta UMS; CA125 ya da CDS ile birlikte kullanılmalıdır. Premenopozal grupta, C/4/25 yeterince güvenilir olmayıp, CDS mutlaka morfolojik değerlendirmeye ilave edilmelidir. Peritoneal sitoloji etkin bir yöntem olarak bulunmamıştır.

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Cite This Article

TEKELİOĞLU, M., ZEYBEK, E., AYANOĞLU, Y. T. (2004). Diagnostic effectiveness of ultrasonographic morphologic scoring, serum CA125 level, color Doppler sonography and peritoneal cytology for malign-benign differentiation of the adnexal mass. Şişli Etfal Hastanesi Tıp Bülteni, Cilt: 38 - Sayı: 3, 64–71. https://ajindex.com/articles/363626

References (15)

  1. Finlder N, Benacerraf B, Lavin F, et al: Comparison of serum CA125, clinical impression, and ultrasound iıı tlıe preoperative evaluation of ovarian masses. Obstet Gyne¬col, 72:659-64, 1988
  2. Timor-Tritscii IE, Lerner JP, Monteagudo A, et ai: Trans- vagina! ultrasonographic catheterisation of ovarian mas¬ses by means of color Doppler measurements and a morphologic scoring system. Am J Obstet Gynecol, l6K:909-!3, 1993
  3. Vasi lev S A, Schlaerth JB, Campeau J, Morrow CP e t al: Serum CA125 levels in preoperative evaluation of pelvic masses. Obstet Gynecol, 71:75 I-6, 1988
  4. Malkasian GD, Knapp RC, Levin PT, et al: Preoperative evaluation of serum CA125 levels in premenapausa! and postmenapausal patients with pelvic masses. Am J Obstet Gynecol 159:341-6, 1988
  5. Zurawsky VR, Broderick AF, Pickens P, et al: Serum CA 125 levels in a group of nonhospitalized women. Obs¬tet Gynecol, 69:606-11, 1987
  6. Schutter EM, Kenemans D, Sohn C, et al: Diagnostic value of pelvic examination, ultrasound and serum CA125 in postmenapausal women with apelvic mass. Cancer, 74:1398-406, 1994
  7. Herman UJ, Locker GW, Goldhirsch A: Sonographic pat¬terns of ovarian tumor. Obstet Gynecol, 69:777-81, 1987
  8. Sassone AM, Timor-1Tritsch IE, Artner A, et al: Trans¬vaginal sonografic caracterisation of ovarian disease. Obstet Gynecol, 78:70-6, 1991
  9. Haberal A, Turgut F, Koç S, Özfuttu A: Posîmcnapozal adneksiyal kitlelerde ultrasnnografik bulgular ile hİs- topatoloji sonuçlarının karşılaştırılması. T Klin Jinekol Obst, 1:32-5, 1994
  10. Strigini FA, Gadduci A, De] Bravo B, et al: Differential diagnosis of adnexa! masses with transvaginal sonog- rapliy, color How imaging, anil CA 125 assey in pre-and postmenapausa] women. Gynecol Oncol, 61:68-72, 1996
  11. Timmerman D, Verneisl H, Bourne TA, et al: Artificial neural network odels for the preoperative discrimination between malign and benign adnexul masses. Ultrasound Obstet Gynecol, 13:17-25, 1999
  12. Jacobs 1, Oram D, Fairbanks J, et al: Ultrasound and menapausal status for the accurate preoperative diagnosis of ovarian cancer. Br J Obstet Gyneacol, 97:922-29, 1990
  13. Davies AP, Jacobs I, Woolas R, el al: The adnexal mass: Benign or maignant?, 100:927-31, 1993
  14. Menon U, Talaat A, Rosenthal AN, et al: Performance of ultrasound as a second line test to serum CA 125 in ovarian cancer screening. Br J Obstet Gyneacol, 107:165- 9, 2000
  15. O'Connell GJ, Ryan E, Murphy KJ, Prefontaine M: Predictive value of CA 125 for ovaria