Results: The difference between hypothyroidism and control groups regarding inflammation was statistically significant p
📌 3 Key Takeaways
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Objective & Hypothesis:Objectives: This study aims to investigate the histopathological changes in nasal mucosa and alterations in thyroid hormone receptors in an experimental postnatal hypothyroidism model.
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Key Findings & Data:Materials and Methods: Twenty-one Wistar albino newborn rats born from the pregnant rats were enrolled in this prospective randomized study and were divided into two groups: Group 1 n=11, methimazole, MMI -induced hypothyroidism group given MMIwater, and Group 2 n=10, control group , normal tap water.
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Conclusion & Impact:Results: The difference between hypothyroidism and control groups regarding inflammation was statistically significant p
Objectives: This study aims to investigate the histopathological changes in nasal mucosa and alterations in thyroid hormone receptors in an experimental postnatal hypothyroidism model. Materials and Methods: Twenty-one Wistar albino newborn rats born from the pregnant rats were enrolled in this prospective randomized study and were divided into two groups: Group 1 n=11, methimazole, MMI -induced hypothyroidism group given MMIwater, and Group 2 n=10, control group , normal tap water. When the offspring reached 90 days, they were decapitated and the nasal mucosa was removed. Thyroid hormone receptor TR-a, TR-b status was assessed by immunohistochemical staining. Results: The difference between hypothyroidism and control groups regarding inflammation was statistically significant p
BAŞAL, Y., GÜNEL, C., ELİYATKIN, N. Ö., CESUR, G., ERYILMAZ, A. (2018). The effect of experimental hypothyroidism on nasal mucosa. The Turkish Journal of Ear Nose and Throat, Cilt: 28 - Sayı: 1, 21–25. https://ajindex.com/articles/362613
Gluckman JL, Stegmoyert R. Nonallergic rhinitis. In: Paparella MM, Shumrick DA, Gluckman JL, Meyerhoff WL, editors. Otolaryngology. Vol 3. 3rd ed. Philadelphia: W.B. Saunders; 1991. p. 1889-95.
Günel C, Başak HS, Güney E. The relationship between hypothyroidism and rhinitis Tr-ENT 2010;20:163-8. Scadding GK. Non-allergic rhinitis: diagnosis and management. Curr Opin Allergy Clin Immunol 2001;1:15-20. El-Shafie KT. Clinical presentation of hypothyroidism. J Family Community Med 2003;10:55-8.
Black RR, Maxon HR. Benign diseases of the thyroid gland. In: Richard Z, editor. Otolaryngology. 3rd ed. Philadelphia: W.B. Saunders; 1991. p. 2483-97. Weisskopf A. Connective tissue: a synthesis of modern thought and its impact on the understanding of nasal disease. Laryngoscope 1960;70:1029-59.
Kocaturk T, Ergin K, Cesur G, Evlicoglu GE, Cakmak H. The effect of methimazole-induced postnatal hypothyroidism on the retinal maturation and on the Sirtuin 2 level. Cutan Ocul Toxicol 2016;35:36-40.
Sack J, Weller A, Rigler O, Rozin A. A simple model for studying the correction of in utero hypothyroidism in the rat. Pediatr Res 1995;37(4 Pt 1):497-501. Ritter FN. The effects of hypothyroidism upon the ear, hormone receptors with anti-inflammatory effect nose and throat. A clinical and experimental study. Laryngoscope 1967;77:1427-79.
Dykewicz MS, Fineman S, Skoner DP, Nicklas R, Lee R, Blessing-Moore J, et al. Diagnosis and management of rhinitis: complete guidelines of the Joint Task Force on Practice Parameters in Allergy, Asthma and Immunology. American Academy of Allergy, Asthma, and Immunology. Ann Allergy Asthma Immunol 1998;81(5 Pt 2):478-518.
Salib RJ, Harries PG, Nair SB, Howarth PH. Mechanisms and mediators of nasal symptoms in non-allergic rhinitis. Clin Exp Allergy 2008;38:393-404.
Proud GO, Lange RD. The effect of thyroidectomy on the nasal mucosa of experimental animals. Trans Am Laryngol Rhinol Otol Soc 1957;59:46-55. Yen PM. Genomic and nongenomic actions of thyroid hormones. In: Braverman LE, Utiger RD, editors. The thyroid: Fundamental and clinical text. Philadelphia: Lippincott Williams and Wilkins; 2005. p. 135. Dettling J, Franz C, Zimmermann U, Lee SC, Bress A, Brandt N, et al. Autonomous functions of murine thyroid hormone receptor TRa and TRb in cochlear hair cells. Mol Cell Endocrinol 2014;382:26-37.
Altman KW, Haines GK 3rd, Vakkalanka SK, Keni SP, Kopp PA, Radosevich JA. Identification of thyroid hormone receptors in the human larynx. Laryngoscope 2